We report a case study of an adult man with severe COVID-19 who attended Psychological Intervention after prolonged hospitalization in the Intensive Care Unit, intubation and finally, participation in Rehabilitation Programme of a Greek Teaching Hospital in Athens. To export results, a qualitative data analysis were collected from Focused Interview, Psychological Intervention based on Short/ Systemic Psychotherapy and a quantitative data analysis from the Beck Depression Inventory and further triangulation of qualitative and quantitative data took place. The study focuses on the psychology of COVID-19 survivor patient, in line with complex needs, psychological effects and specific stressors, following a life-threatening disease. In the light of a therapeutic ‘flexibility’ and finally of a combination of multi-factorial nature of the disease that requires integration and simultaneous exploring of not only the physical, but also of the psychological needs of the patient