Qualitative Analysis of Peripheral Peri‐Implant Bone and Influence of Alendronate Sodium on Early Bone Regeneration

Meraw, Stephen J.; Reeve, Charles M.

doi:10.1902/jop.1999.70.10.1228

Cited by 90 publications

(63 citation statements)

References 21 publications

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“…in this study, we used hydroxyapatite (hA) as bone graft substitute because in vitro/vivo studies have reported favorable clinical results following surgical treatment of intrabony defects with hydroxyapatite graft materials (14,18,23,38). our results showed that the use of hA granules did not cause any undesirable reaction.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats

Arslan

Altundal

Çevik

et al. 2011

Biotechnology & Biotechnological Equipment

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Section: Resultsmentioning

confidence: 99%

Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats

Arslan

Altundal

Çevik

et al. 2011

Biotechnology & Biotechnological Equipment

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“…Several studies have investigated the use of bisphosphonates as adjuvant in implant fixation. [5][6][7][8][9][10] The general findings were increased peri-implant bone density or reduced implant migration.…”

Section: Introductionmentioning

confidence: 99%

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Jakobsen

Kold

Bechtold

et al. 2006

Journal Orthopaedic Research

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Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri-implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4-week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion. On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone-to-implant contact (1.2-fold), and peri-implant bone volume fraction (2.3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown. ß

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“…The local drug delivery approach has been tested in vivo with no negative effects but only slight increase in implant osteointegration for dental implants [25,26] or for bulk hydroxyapatite blocks [7,8]. Recently, Yoshinari et al [44] used plasmasprayed HA-coated titanium dental implant which were immersed in pamidronate and implanted in beagle mandibular bone.…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Peter

Pioletti

Laı̈b

et al. 2005

Bone

249

167

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Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium implants. The implants were inserted in rat condyles with various zoledronate concentrations. A positive concentration-dependent effect was observed on the peri-implant bone density and on different histomorphometric parameters. Importantly for the outcome of the implants, the mechanical fixation was increased by the local presence of zoledronate.The obtained results open the way of an easy transformation of currently existing HA-coated implants by grafting bisphosphonate onto the coating in order to increase their service life in the patients. D 2004 Elsevier Inc. All rights reserved.

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Qualitative Analysis of Peripheral Peri‐Implant Bone and Influence of Alendronate Sodium on Early Bone Regeneration

Cited by 90 publications

References 21 publications

Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats

Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats

Local alendronate increases fixation of implants inserted with bone compaction: 12‐week canine study

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

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