Qualitative analysis of designer drugs by paper spray ionisation mass spectrometry (PSI-MS)

Carvalho, Thays Colletes de; Oliveira, Izabela F.; Tose, Lílian V.; Vanini, Gabriela; Kill, Jade Barbosa; Neto, Álvaro Cunha; Machado, Leandro F.; Ambrósio, João Carlos Laboissiere; Lacerda, Valdemar; Vaz, Boniek G.; Romão, Wanderson

doi:10.1039/c5ay01265a

Cited by 40 publications

(34 citation statements)

References 27 publications

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“…Of note, MS/MS spectra obtained from NBOMe derivatives using the CIT of the AI-MS 1.2 demonstrated much higher complexity compared to that contained in the Wiley Registry of Tandem MS Data (Supplementary Figure S-8C), although there have been similar reports in recent literature [28,68,69]. It has been asserted that the addition of the N-(2-methoxy)benzyl group to the 2C-phenethylamine structure (another electron donating aromatic ring, as seen in Supplementary Figure S-8C) creates more favorable sites for dissociation that can occur along the -C-C-N-C-linkage chain, specifically C-C bond cleavage between the α-and β-carbon atoms on the ethylene bridge [68,69].…”

Section: Selectivity Of Analyte Identificationmentioning

confidence: 70%

“…Previous work towards establishing spectral congruence and selectivity compared blind portable MS/MS data to a widely accepted reference library, the 'Wiley Registry of Tandem Mass Spectral Data, MSforID', returning the correct identification for over 30 forensic analytes and evidentiary samples [44]. While this shows selectivity towards traditional drugs of abuse, extension towards novel psychoactive substances (NPS) [28], particularly those that are structurally similar and even isomeric, must be assessed.…”

Section: Selectivity Of Analyte Identificationmentioning

confidence: 99%

“…Ambient MS techniques [13,14], which increase sample throughput by forgoing extensive sample preparations, have shown proficiency in forensic chemical analysis [15][16][17], with recent reports involving the analysis of biofluids [18,19], explosives [20], adulterated foodstuffs [21], mind-altering plant-based evidence [22], and simultaneous molecular/elemental composition [23]. Specific techniques like desorption electrospray ionization (DESI) [24], direct analysis in real time (DART) [25], and paper spray ionization (PSI) [26,27] have shown utility in both trace and bulk drug evidence analysis, particularly in combatting the rise of Bdesigner drugs^evidence and accommodating associated paraphernalia [28].…”

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

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Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. Forensic evidentiary backlogs are indicative of the growing need for costeffective, high-throughput instrumental methods. One such emerging technology that shows high promise in meeting this demand while also allowing on-site forensic investigation is portable mass spectrometric (MS) instrumentation, particularly that which enables the coupling to ambient ionization techniques. While the benefits of rapid, on-site screening of contraband can be anticipated, the inherent legal implications of field-collected data necessitates that the analytical performance of technology employed be commensurate with accepted techniques. To this end, comprehensive analytical validation studies are required before broad incorporation by forensic practitioners can be considered, and are the focus of this work. Pertinent performance characteristics such as throughput, selectivity, accuracy/precision, method robustness, and ruggedness have been investigated. Reliability in the form of false positive/negative response rates is also assessed, examining the effect of variables such as user training and experience level. To provide flexibility toward broad chemical evidence analysis, a suite of rapidly-interchangeable ion sources has been developed and characterized through the analysis of common illicit chemicals and emerging threats like substituted phenethylamines.

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Section: Selectivity Of Analyte Identificationmentioning

confidence: 70%

Section: Selectivity Of Analyte Identificationmentioning

confidence: 99%

Section: A Review Of the 2009 Census For Publicly Funded Forensicmentioning

confidence: 99%

See 1 more Smart Citation

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Lawton

Traub

Fatigante

et al. 2016

J. Am. Soc. Mass Spectrom.

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“…Then, 10 µL of solution was applied on the surface of a triangular paper (Whatman Grade 1, GE Healthcare) 27,28 with base and height of 1 cm each. The triangular paper was fixed with a metal clip, connected to 0.5 mm wire linked to the mass spectrometer (Figure 1b).…”

Section: Ps-ms and Ls-msmentioning

confidence: 99%

“…27,29 Ion time accumulation was 0.010 s. LS(+) and PS(+)-FT-ICR mass spectra were acquired by accumulating 32 scans of timedomain transient signals in 16 mega-point time-domain data sets. All mass spectra were externally calibrated using NaTFA (m/z from 200 to 1200).…”

Section: Ps-ms and Ls-msmentioning

confidence: 99%

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS‑MS and LS-MS)

Bessa

Andrade

Domingos

et al. 2016

J. Braz. Chem. Soc.

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Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others. Mass spectrometry (MS) studies based on capillary gas chromatography (CGC), paper spray (PS), and leaf spray (LS) ionization were carried out for alkaloid investigation of the native Brazilian species Hippeastrum aulicum, along with nuclear magnetic resonance (NMR) techniques. Thirty-one alkaloids were identified including the new compound haemanthamine N-oxide. The results from PS-and LS-MS techniques were consistent with those observed in CGC-MS analysis. To the best of our knowledge, it is the first study combining NMR, CGC-MS and the ambient ionization-mass spectrometry (PS-and LS-MS) on Amaryllidaceae plants.

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Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction

Zimmerman‐Federle,

Ren,

Dowling

et al. 2024

Drug Testing and Analysis

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Drug overdoses have risen dramatically in recent years. We developed a simple nontargeted method using a disposable paper spray cartridge with an integrated solid phase extraction column. This method was used to screen for ~160 fentanyl analogs, synthetic cannabinoids, other synthetic drugs, and traditional drugs of abuse in over 300 authentic overdose samples collected at emergency departments in Indianapolis. A solid phase extraction step was implemented on the paper spray cartridge to enable subnanograms per milliliter synthetic drugs screening in plasma. Analysis was performed on a quadrupole orbitrap mass spectrometer using the sequential window acquisition of all theoretical fragment ion spectra approach in which tandem mass spectrometry was performed using 7 m/z isolation windows in the quadrupole. Calibration curves with isotopically labeled internal standards were constructed for 35 of the most frequently encountered synthetic and traditional illicit drugs by US toxicology labs. Additional qualitative‐only drugs in a suspect screening list were also included. Limits of detection in plasma for synthetic cannabinoids ranged from 0.1 to 0.5 and 0.1 to 0.3 ng/mL for fentanyl and its analogs and between 1 and 5 ng/mL for most other drugs. Relative matrix effects were evaluated by determining the variation of the calibration slope in 10 different lots of biofluid and found to be between 3% and 20%. The method was validated on authentic overdose samples collected from two emergency departments in Indianapolis, Indiana, from suspected or known overdoses. Commonly detected synthetic drugs included fentanyl related substances, designer benzodiazepines such as flubromazolam, and the synthetic cannabinoid 5F‐PB‐22.

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Qualitative analysis of designer drugs by paper spray ionisation mass spectrometry (PSI-MS)

Cited by 40 publications

References 27 publications

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS‑MS and LS-MS)

Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction

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