Objective: Investigate maternal mortality on the borders of Brazil/Paraguay and Brazil/Bolivia in Mato Grosso do Sul. Methods: Descriptive study, exploratory, quantitative approach using the Mortality Information System and the Live Birth Information System, on the ten(10) cities on the border of Mato Grosso do Sul, which presented maternal death certificates from 2012 to 2018. Maternal mortality and specific maternal mortality ratios were calculated and maternal deaths were analyzed according to obstetric variables. Results: The cities had high Maternal Mortality Ratios in relation to state and national averages. In the years 2014, 2015 and 2016 there were the highest numbers of maternal deaths, from 2013 to 2014, there was a jump, from 2 to 8 maternal deaths. For the specific maternal mortality ratio, there was a predominance of women 40-49 years old (254, 4/100.000), with 4-7 years of education (148,4/100.000), black (852,9/100.000), single (159,1/100.000), and deaths were more common during the postpartum period (60%) and due to direct obstetric causes (75%). Conclusion: The high occurrence of maternal death in border municipalities reflects the weakness in care for prenatal care, childbirth and the puerperium, combined with the social vulnerability experienced by resident women.