The aim of the present study is the investigation of the levels of quality of life and pain self-efficacy among chronic disease patients undergoing occupational therapy. The sample consists of 63 people, all chronic disease patients. Of the above patients, according to the research design, half receive Occupational Therapy services at a rate of 50.8% (32 patients) while the remaining 49.2% (31 people) did not receive. For the data collection MVQOLI-15 and PSEQ were used. We found that the average value of the sample regarding self-efficacy amounts to 39.10 (SD: 13.25), from which we can conclude that the sample appears moderately self-efficacious. Beyond this, the minimum value of self-efficacy amounts to 11,000 while the corresponding maximum to 64,00. Also, in general the sample appears to be neutral regarding its overall quality of life with the corresponding average value of the scale amounting to 15.86 ( SD: 3.09). The value range is found from 9.60 to 22.50, while the median value is 15.80.