Quali-quantitative synthesis between clinical trials and patents on Covid-19 associated with CRISPR

Abstract

Introduction: The work presents a comparative analysis between clinical trials and patent families on COVID-19 associated with CRISPR-Cas, ACE2 and Spike worldwide. Methods: From a total of 7815 clinical trials dedicated to COVID-19, 238 clinical trials related to CRISPR-Cas, ACE2 and Spike were identified, and 112 patent families. For the recovery of clinical trials and patent families, the ICTRP® platform of the World Health Organization, the ORBIT INTELLIGENCE® system from Questel® and the INPI COVID-19 Observatory were used, respectively. Results: Through quantitative and qualitative analysis and synthesis, a pattern of insignificant similarity was observed between the institutions that sponsor clinical trials and holders of patent families, among other correlated indicators. Conclusions: In summary, it is suggested that new public policies be created to encourage synergy between clinical trials and patents, both national, in order to induce a safe path to technological independence and, consequently, better performance in combating COVID-19 associated with CRISPR-Cas, ACE2 and Spike in Brazil.