Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action

Mazzolin, Lucilene Patrícia; Nasser, Ana Lúcia Martiniano; Moraes, Thiago Mello; Santos, R. C. dos; Nishijima, Catarine Massucato; Santos, Fábio V.; Varanda, Eliana Aparecida; Bauab, Taís Maria; Rocha, Lúcia Regina Machado da; Stasi, L. C. Di; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2009.10.005

Cited by 28 publications

(31 citation statements)

References 34 publications

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“…Additionally, the gastroprotective effects stopped acting on gastric mucosa (only 60% vs. 98%) when the animals had been pretreated with a sulphydryl (SH) inhibitor. These results support the hypothesis that the activity observed in Q. parviflora is directly related to its capacity of complexing with the gastric mucosal barrier, probably caused by phenolic compounds like flavonoids and ellagic acid derivatives (Mazzolin et al 2010).…”

Section: Antiulcer Activitysupporting

confidence: 87%

“…The evaluation of diarrheal activity induced by castor oil showed that the crude ethanol bark extract of Q. parviflora significantly (P \ 0.01) diminished 75 4,2 0 ,4 0 -tribenzyloxy-6 0 -trihydroxy-chalcone Fruits Vochysia guianensis Baudouin et al (1983) 7-benzyloxy-4 0 -hydroxy-5-methoxy-flavane Synthesis Vochysia guianensis Baudouin et al (1983) diarrhea by 66%, in relation to the control group (30%) and the standard control loperamide (93%) (Mazzolin et al 2010). …”

Section: Anti-diarrheal Activitymentioning

confidence: 99%

“…The gastroprotective action of Qualea grandiflora, Q. parviflora and Vochysia tucanorum was evaluated in rodent experimental models using HCl/ethanol, absolute ethanol and nor-steroidal anti-inflammatory drugs (NSAID) (Gomes et al 2009;Mazzolin et al 2010;Hiruma-Lima et al 2006).…”

Section: Antiulcer Activitymentioning

confidence: 99%

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Vochysiaceae: secondary metabolites, ethnopharmacology and pharmacological potential

et al. 2011

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Many Vochysiaceae species, in special Qualea and Vochysia genera, are widely used in folk medicine to treat several diseases. This review describes some aspects of their ethnopharmacology potential, biological activity and the secondary metabolites reported so far for Vochysiaceae. The chemical constituents of this family include triterpenoids, steroids and polyphenols like flavonoids and ellagic acid derivatives.

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Section: Antiulcer Activitysupporting

confidence: 87%

Section: Anti-diarrheal Activitymentioning

confidence: 99%

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Vochysiaceae: secondary metabolites, ethnopharmacology and pharmacological potential

et al. 2011

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“…Therefore, there is a lack of information to describe any true potential. [6][7][8] The biological activity of medicinal plants from all over the world has been studied by several groups of researchers. These studies are based on the popular uses of different species, 9 as well as on popular knowledge and scientific studies describing medical plant use, with a focus on how these plants could benefit the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-based drug delivery systems and herbal medicines: a review

Bonifácio¹,

Silva²,

Ramos³

et al. 2013

IJN

250

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Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

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“…In fact, several plants provide health benefits by exhibiting antihemorrhagic (Mazzolin et al, 2010), antioxidant (Souza et al, 2012), and antimutagenic activities (Vilar et al, 2009b). Moreover, several studies have demonstrated that numerous active compounds from Brazilian Cerrado plants show promising biological properties for cancer therapy (de Mesquita et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

Fd¹,

Silva²,

Sampaio³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleus test. In the Ames test, EESB did not significantly increase the number of His + revertants in Salmonella typhimurium tester strains TA98 and TA100 at all doses, demonstrating lack of mutagenicity. Only the highest dose of EESB significantly increased the micronucleated polychromatic erythrocyte frequency in the micronucleus test, indicating mild genotoxicity. EESB produced a mutagenic index lower than the negative control in the Ames test. In the micronucleus test, at all doses, EESB caused a significant decrease in the polychromatic/normochromatic erythrocyte ratio (PCE/NCE) at 24 h compared with the negative control. EESB co-administered together with the respective positive control caused a significant decrease in the number of His + revertant colonies in the Ames test and in the frequency of micronucleated polychromatic erythrocytes in the micronucleus test, demonstrating a DNA protector effect. EESB co-administered with mitomycin C significantly increased the PCE/NCE ratio at all doses, showing an anticytotoxic effect. We conclude that EESB has antigenotoxic and anticytotoxic properties.

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Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action

Cited by 28 publications

References 34 publications

Vochysiaceae: secondary metabolites, ethnopharmacology and pharmacological potential

Vochysiaceae: secondary metabolites, ethnopharmacology and pharmacological potential

Nanotechnology-based drug delivery systems and herbal medicines: a review

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

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