Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers

Abstract

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches

“…Interestingly, G4s in mRNAs of EBV and KSHV were reported to modulate the mechanism of immune evasion with two different mechanisms, suggesting that G4s may play a role in the strategies of viral latency. 114 , 116 , 117 , 119 …”

“…The latency program of viruses allows them to survive inside the host and protects them from the immune surveillance of the host. Interestingly, G4s in mRNAs of EBV and KSHV were reported to modulate the mechanism of immune evasion with two different mechanisms, suggesting that G4s may play a role in the strategies of viral latency. ,,, …”

“…The destabilization of EBNA1 mRNA G4s using antisense oligonucleotides increases EBNA1 mRNA translation. In contrast, pretreatment with a G4–stabilizing small molecule reduces EBNA1 synthesis. , Destabilization of these G4 structures limits both the presentation of MHC class I-restricted CD8 + T cell epitopes by CD11c + dendritic cells in draining lymph nodes and early priming of antigen-specific CD8 + T-cells . In addition, cellular nucleolin, which was reported to interact with G4s in EBNA1 mRNA, was also involved in the latency of EBV …”

“…HSV-1/ds DNA inverted repeats region 88,93 regulating viral replication and transcription 88−92 packaging signal (pac1) 89 virus entry 92 immediate early promoters 90,91 determine the landscape of recombination 111 unique long (UL) region 111 HPV/ds DNA long control region (LCR) 94 regulating viral transcription 94 L1, E1, and E4 coding regions 94 CMV/ds DNA promoter or gene regulatory regions 112 affecting gene expression 112 KSHV/ds DNA terminal repeats 113 alter latent DNA replication and episomal persistence 113 LANA mRNA 114 causing latency 113,114 HHV-6/ds DNA direct repeat regions 115 modulating the interaction of viral genome into host genome to cause latency 115 EBV/ds DNA EBNA1 mRNA 116,117 regulating viral replication and transcription 116−118 modulating immune evasion 119,120 HIV-1/(+) ssRNA long terminal repeats 97−101,94−98 modulate the interaction of viral genome into host genome 97−100 U3 region 97,100,101 regulating viral transcription 97,100,101 regulating revers transcription cant reduction in the HHV-6A integration frequency; in contrast, it had no effect on the HHV-6 integration frequency in U2OS cells that lack telomerase activity. Thus, cellular G4 formation in telomeres is important for efficient chromosomal integration of HHV-6A.…”

Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA

“…Progresses in the structural characterization of G4s and in the identification of their involvement in some diseases such as cancer [14,15] or others [5,16,17] led to massive efforts toward the synthesis of G4-ligands [18][19][20][21][22][23][24]. Some G4-ligands indeed showed biological activity, among which antiviral properties is an emerging field [10,[25][26][27][28].…”