Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)

Abstract

Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori.

Efficacy of 2-Week, Second-Line Helicobacter pylori Eradication Therapy Using Rabeprazole, Amoxicillin, and Metronidazole for the Japanese Population

“…A recent Japanese study also showed a high eradication rate with similar, 2-week, second-line therapy of omeprazole, amoxicillin, metronidazole, and ecabet sodium (a mucoprotective agent) (96% (50 ⁄ 52) by ITT analysis and 98% (50 ⁄ 51) by PP analysis) [22]. A recent Japanese study also showed a high eradication rate with similar, 2-week, second-line therapy of omeprazole, amoxicillin, metronidazole, and ecabet sodium (a mucoprotective agent) (96% (50 ⁄ 52) by ITT analysis and 98% (50 ⁄ 51) by PP analysis) [22].…”

“…AST or ALT value was elevated in 5 (8%) of 65 patients, but the elevation was also mild (AST values prior to treatment, 1 and 2 week later, 20 ± 3 (range, [16][17][18][19][20][21][22], 35 ± 10 (23-43), and 47 ± 4 (42-50) IU ⁄ L; and ALT, 20 ± 3 (18-23), 37 ± 8 (30-45), and 64 ± 13 (48-77) IU ⁄ L, respectively). Although the elevation was mild (AST, from 28 ± 4 (range, 23-35) to 52 ± 14 (33-81) IU ⁄ L; and ALT, from 32 ± 12 (17-60) to 59 ± 19 (39-103) IU ⁄ L), they discontinued therapy for safety.…”

“…The remaining 67 patients continued therapy and hematological examination was repeated 1 week later. AST or ALT value was elevated in 5 (8%) of 65 patients, but the elevation was also mild (AST values prior to treatment, 1 and 2 week later, 20 ± 3 (range, [16][17][18][19][20][21][22], 35 ± 10 (23-43), and 47 ± 4 (42-50) IU ⁄ L; and ALT, 20 ± 3 (18-23), 37 ± 8 (30-45), and 64 ± 13…”

Systematic review, meta‐analysis, and meta‐regression: Successful second‐line treatment forHelicobacter pylori

“…Of these, 61 arms (30%) showed PP cure rates >90% . Two studies (two arms) evaluated a dual therapy (rabeprazole and amoxicillin), 34 arms evaluated a triple therapy (Table ), and 25 arms evaluated quadruple therapies (Table ).…”

An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice

“…16 Infection by this bacterium could potentially result in various gastroduodenal diseases such as peptic ulcer, functional dyspepsia, MALT lymphoma, and [23][24][25] compare the accuracy of the UBT to several other invasive diagnostic tests such as gastric biopsies performed during endoscopy (rapid urease test, histology, culture) and a large number of papers [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] have focused on the efficacy of eradication therapy and the selection of alternate therapies. 16 Infection by this bacterium could potentially result in various gastroduodenal diseases such as peptic ulcer, functional dyspepsia, MALT lymphoma, and [23][24][25] compare the accuracy of the UBT to several other invasive diagnostic tests such as gastric biopsies performed during endoscopy (rapid urease test, histology, culture) and a large number of papers [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]…”