Quadruple Extra-mammary Paget's disease

Abe, Shoko; Kabashima, Kenji; Nishio, Daisuke; Yasuda, Hiroshi; Tokura, Y.

doi:10.2340/00015555-0169

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Ectopic EMPD has the same gender tendency as non-ectopic EMPD. More interestingly, there have been 68 reported Japanese cases of triple or quadruple EMPD, whereas only one case of triple EMPD has been reported outside of Japan (36). This is in accordance with the ethnic difference found in ectopic EMPD.…”

Section: Forming Ductal Structures (Haematoxylin and Eosin (Hande); Orisupporting

confidence: 56%

Ectopic Extramammary Paget’s Disease: Case Report and Literature Review

Sawada¹,

Bito²,

Kabashima³

et al. 2010

Acta Derm Venerol

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Extramammary Paget's disease that occurs in non-apocrine-bearing regions is referred to as ectopic and has been rarely reported. A 62-year-old man presented with a slowly progressive, asymptomatic light-brown plaque on his back. Histopathological examination revealed the presence of large pale cells with prominent nuclei, which proliferated diffusely and focally in the epidermis. Immuno-histochemically the tumour cells were positive for CK7, GCDFP-15, CEA, and p63. Based on these findings, we diagnosed the tumour as ectopic extramammary Paget's disease. We reviewed the English and Japanese literature and found 29 previously reported cases of ectopic extramammary Paget's disease, including our case, with a predominance of occurrence in the Asian population. The germinative milk line is known to be a possible site where extramammary Paget's disease occurs. Like-wise, some germinative apocrine-differentiating cells might exist on the trunk preferentially in Asians. Attention should be paid to the development of ectopic as well as triple or quadruple EMPD in Asians.

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Section: Forming Ductal Structures (Haematoxylin and Eosin (Hande); Orisupporting

confidence: 56%

Ectopic Extramammary Paget’s Disease: Case Report and Literature Review

Sawada¹,

Bito²,

Kabashima³

et al. 2010

Acta Derm Venerol

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“…In this study, we counted lesions from the anal, perineal, and genital areas as single lesions because they were anatomically adjacent. We reviewed six cases of quadruple EMPD, including our case, with respect to race, sex, age, site, recurrence, time to recurrence, and depth (Table 1) [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Ishiguro,

Iwashita,

Abe

et al. 2024

Case Rep Dermatol

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Introduction: Extramammary Paget’s disease (EMPD) is a rare skin cancer that tends to be multicentric, with quadruple EMPD cases being scarcely reported. Case Presentation: We report the case of an 81-year-old man with heterochronous quadruple EMPD. Twelve years after total resection of vulvar EMPD, the patient developed erythematous lesions on the resection margin in the lower abdomen, umbilical region, and both axillae. Histological examination revealed that all lesions were in situ EMPD. Discussion: We reviewed six reported cases of quadruple EMPD with respect to race, sex, site, recurrence, time to recurrence, serum carcinoembryonic antigen, and depth. All patients were elderly Japanese males. In all but one case, the lesions were located in the apocrine region, which is a common site in such as the genital and axillary areas. Our case was the only heterochronous quadruple EMPD. The lesions were limited to the epidermis; therefore, they were unlikely to cause metastasis. It has been reported that the therapeutic effects of imiquimod can be expected in in situ EMPD. Therefore, quadruple EMPD may be a good indication of treatment option. Conclusion: EMPD is a disease whose pathogenesis is not yet clear; however, it is hoped that the origin and aetiology of EMPD will be elucidated from the clinical features of multiple EMPD in the future.

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Extramammary Paget’s Disease

Mărgăritescu¹,

Chirita

2014

Rare Malignant Skin Tumors

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Quadruple Extra-mammary Paget's disease

Cited by 6 publications

References 5 publications

Ectopic Extramammary Paget’s Disease: Case Report and Literature Review

Ectopic Extramammary Paget’s Disease: Case Report and Literature Review

Recurrence of Quadruple Extramammary Paget’s Disease after 12 Years: A Case Report and Literature Review

Extramammary Paget’s Disease

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