Quadrivalent HPV Vaccination and Risk of Multiple Sclerosis and Other Demyelinating Diseases of the Central Nervous System

Scheller, Nikolai Madrid; Svanström, Henrik; Pasternak, Björn; Arnheim-Dahlström, Lisen; Sundström, Karin; Fink, Katharina; Hviid, Anders

doi:10.1001/jama.2014.16946

Cited by 151 publications

(66 citation statements)

References 30 publications

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“…25,31,37 The extensive claims-based algorithm developed based on the process of medical care was able to identify potential cases of ON from the claims data, but the PPV for case adjudication was low (40% using all charts obtained and 62.5% using as denominator the 64 charts that had enough information for the reviewers to make a determination). In our validation study, among 144 patients with optic neuritis, medical charts were unobtainable for 30.6% (44 patients) due to various reasons such as providers reporting that no records were available or there was no record of the patient.…”

Section: Discussionmentioning

confidence: 99%

“…30 Also, a recently published study from 2 Scandinavian countries, using nationwide registries, followed a cohort of almost 4 million females for up to seven years and found no association between the quadrivalent HPV vaccine and multiple sclerosis or other demyelinating diseases. 31 Although temporal associations of adverse events with vaccination will always occur, temporal associations alone do not prove causality. 26,32 Because HPV vaccines are administered to young females who are more likely to develop autoimmune diseases irrespective of vaccination, these events could occur by chance alone.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of optic neuritis following human papillomavirus vaccination

Sridhar¹,

Tian²,

Forshee

et al. 2017

Human Vaccines & Immunotherapeutics

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To assess the relationship between human papillomavirus (HPV) vaccination and occurrence of optic neuritis (ON) and to evaluate a claims-based algorithm for identification of ON. Females of 9-26 year olds in the HealthCore's Integrated Research Database (HIRD SM ) with and without claims evidence of HPV vaccination between 2007 and 2012 were included in this study. Potential ON cases were identified using the claims-based algorithm, positive predictive value (PPV) was determined using medical chart review. For the claims analysis, two study designs, a self-controlled temporal scan statistic and a retrospective matched cohort analysis, were used. ON was defined based on an algorithm developed using diagnosis and procedure codes from the medical claims. The PPV for ON cases using charts that had enough information for reviewers to make a determination was 62.5% (95% CI: 49.5%-74.3%). With the selfcontrolled temporal scan statistic, the primary analysis restricting on recommended vaccination schedule timing showed an increased risk of potential ON after second dose (RR D 3.39; p D 0.03), this finding was not confirmed for any of the additional analyses performed for individual or combined doses. With the cohort design, there was no increased risk of potential ON following vaccination in either individual or combined dose analyses. The risk of potential ON was higher among participants with a history of prior autoimmune diseases. In conclusion, identifying confirmed ON cases through administrative claims data proved challenging. The claims-based analysis in this study did not provide evidence for an association of ON with HPV vaccination.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of optic neuritis following human papillomavirus vaccination

Sridhar¹,

Tian²,

Forshee

et al. 2017

Human Vaccines & Immunotherapeutics

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“…Si la exposición subsiguiente después de la inmunización sirve como un refuerzo, la duración de la protección puede ser prolongada, especialmente en aquellos casos involucrados en comportamientos de alto riesgo, como tener más parejas sexuales y, por tanto, una mayor exposición al VPH, según algunos autores (112)(113)(114). Finalmente, cabe anotar que se han documentado algunos efectos secundarios (115)(116)(117)(118)(119); en este sentido, al respecto existen entidades encargadas de regular este tipo de información, basadas en los posibles eventos adversos asociados con las vacunas (120)(121)(122)(123).…”

Section: Según El Servicio De Medicina Preventiva Y Gestión De Calidaunclassified

Naprotecnología: ciencia y persona en la infección por el virus del papiloma humano (VPH) en mujeres y preadolescencentes

et al. 2017

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En la actualidad hay suficiente evidencia científica que relaciona directamente adquisición, exposición y prevalencia del virus del papiloma humano (VPH) con el cáncer del cuello de uterino. Por ello, el artículo aborda el VPH en la mujer teniendo en cuenta la naprotecnología, que permite conjugar evidencia científica y planteamientos éticos. Se busca que se tengan en cuenta tanto el aspecto biológico de la sexualidad como la capacidad de hacerse persona en su núcleo sexual. De ahí que se analicen programas dirigidos a la educación sexual, basados tanto en la prevención sanitaria como en la antropología de la sexualidad, y apoyados por las instituciones familiares, que han demostrado una mejor acogida ante los riesgos de las enfermedades de transmisión sexual, y entre ellas la infección por el VPH.

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“…Französische A utoren führten e ine Kohortenstudie mit einer mit der dänisch-schwedischen Arbeit vergleichbaren Methodik durch [7,8]. …”

Section: Polyradikulitis Guillain-barréunclassified