Quadriceps myositis: an appraisal of the diagnostic criteria of quadriceps myopathy

Abstract

Case reports 757 he received several blood transfusions which may have provided sufficient lymphocytes to mount an attack against the warts. The marked depletion of peripheral lymphocytes in this patient was in contrast to the maintenance of normal serum proteins, including immunoglobulins. This is of interest in view of the close similarity of hyperplastic lymphoid follicles (Fig. 6) with the nodular lymphoid hyperplasia found in hypogammaglobulinaemia (Hermans et al., 1966) and which is known to be associated with infection with Giardia lamblia.Despite the marked depression of immune function in patients with lymphangiectasia opportunistic infections do not appear to be unduly common (Strober et al., 1967) and the authors have been unable to find any other reports of malignancy complicating this condition. It is perhaps the severity of their patient's lymphocyte depletion which has accounted for the appearance of such gross viral warts and ultimately to the complication of small intestinal lymphoma.

Quadriceps Myositis.

“…Despite the goitor, she was in the euthyroid state, which suggested little possibility of the presence of autoimmune thyroid disease. Quadriceps myopathy is a syndrome which shows muscular atrophy and weakness localized in the thighs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). However, previous reports revealed weakness of other muscles in the pelvic girdles or upper extremities or EMG abnormalities without clinical symptoms (5,7,10,12) as seen in the present case.…”

“…Quadriceps myopathy is a syndrome of chronic and slowly progressive atrophy and weakness of the muscle in the thigh; most cases are considered to be a myogenic disorder and some cases are thought to be neurogenic (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Of these, myositis localized in the thigh is a rare condition.…”

Quadriceps myopathy caused by skeletal muscle-specific ablation of βcyto-actin

“…There is considerable heterogeneity in QM because etiologies can range from a form of limb-girdle muscular dystrophy (Swash and Heathfield, 1983) to polymyositis (Mohr and Knowlson, 1977;Turner and Heathfield, 1961). Genetic variants of QM are suspected to arise from autosomal dominant (Charniot et al, 2006;Espir and Matthews, 1973), autosomal recessive (Jarry et al, 2007;Mahjneh et al, 2003), and X-linked recessive (Kumari et al, 2000;Wada et al, 1990) inheritance patterns, indicating that several gene products probably play a role in QM pathology.…”