Quadriceps Lipid Content Has Sex-Specific Associations With Whole-Muscle, Cellular, and Molecular Contractile Function in Older Adults

Straight, Chad R.; Voigt, Thomas; Jala, Anudeep V; Chase, John D.; Ringham, Olivia R; Ades, Philip A.; Toth, Michael J.; Miller, Mark S.

doi:10.1093/gerona/gly235

Cited by 15 publications

(8 citation statements)

References 49 publications

(101 reference statements)

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“…Besides metabolic associations, excess adiposity also affects functional capacity. Lower muscle density, reflecting increased adipose tissue infiltration into the muscle compartment, is associated with whole‐body adiposity (Goodpaster et al, 2000 ) and can lead to decreased muscle power and postural balance (Straight et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Total and regional body adiposity increases during menopause—evidence from a follow‐up study

et al. 2022

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For women, menopausal transition is a time of significant hormonal changes, which may contribute to altered body composition and regional adipose tissue accumulation. Excess adiposity, and especially adipose tissue accumulation in the central body region, increases women's risk of cardiovascular and metabolic conditions and affects physical functioning. We investigated the associations between menopausal progression and total and regional body adiposity measured with dual-energy X-ray absorptiometry and computed tomography in two longitudinal cohort studies of women aged 47-55 (n = 230 and 148, mean follow-up times 1.3 ± 0.7 and 3.9 ± 0.2 years, mean baseline BMI 25.5 kg/m 2 ). We also examined associations between menopausal progression and skeletal muscle fiber characteristics, as well as adipose tissue-derived adipokines. Relative increases of 2%-14% were observed in regional and total body adiposity measures, with a pronounced fat mass increase in the android area (4% and 14% during short-and long-term follow-ups). Muscle fiber oxidative and glycolytic capacities and intracellular adiposity were not affected by menopause, but were differentially correlated with total and regional body adiposity at different menopausal stages. Menopausal progression and regional adipose tissue masses were positively associated with serum adiponectin and leptin, and negatively associated with resistin levels. Higher diet quality and physical activity level were also inversely associated with several body adiposity measures. Therefore, healthy lifestyle habits before and during menopause might delay the onset of severe metabolic conditions in women.

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Section: Introductionmentioning

confidence: 99%

Total and regional body adiposity increases during menopause—evidence from a follow‐up study

et al. 2022

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“…In this study, Choi et al found that the older adults with obesity exhibited impairments in unloaded shortening velocity (V 0 ) in MHC I fibres (slow), and impaired maximal force output in MHC I fibres and MHC IIa fibres (fast) relative to the older adults who did not have obesity. Straight et al (2019) found that adiposity was negatively correlated with single fibre force per CSA in MHC I and IIa fibres of older women, but not older men. We are not aware of any study which has examined the effects of obesity on contractility of single muscle fibres from young humans or from animals.…”

Section: R a F Tmentioning

confidence: 87%

Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption

Smith

Ostertag

O'Reilly

et al. 2021

Appl. Physiol. Nutr. Metab.

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Obesity is a worldwide health concern associated with impaired physical function. It is not clear if contractile protein dysfunction contributes to the impairment of muscle function observed with obesity. The purpose of this study was to examine if diet-induced obesity affects contractile function of chemically permeabilized vastus intermedius fibres of male Sprague Dawley rats expressing fast myosin heavy chain (MHC) IIa or slow MHC I. Rats consumed either a high-fat, high-sucrose (HFHS) diet or a standard (CHOW) diet beginning as either weanlings (7-week duration: WEAN7 cohort, or 14-week duration: WEAN14 cohort) or young adults (12-week duration: ADULT12 cohort, 24-week duration: ADULT24 cohort). HFHS-fed rats had higher (P<0.05) whole-body adiposity (derived from dual-energy X-ray absorptiometry) than CHOW-fed rats in all cohorts. Relative to CHOW diet groups, the HFHS diet was associated with impaired force production in a) MHC I fibres in the ADULT24 cohort, and b) MHC IIa fibres in the ADULT12 and ADULT24 cohorts combined. However, the HFHS diet did not significantly affect the Ca2+-sensitivity of force production, unloaded shortening velocity, or ratio of active force to active stiffness in any cohort. We conclude that diet-induced obesity can impair force output of permeabilized muscle fibres of adult rats. Novelty Bullets: • We assessed contractile function of permeabilized skeletal muscle fibres in a rat model of diet-induced obesity. • The high-fat, high-sucrose diet was associated with impaired force output of fibres expressing MHC I or MHC IIa in some cohorts of rats. • Other measures of contractile function were not significantly affected by diet.

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“…Intramuscular fat elicits numerous skeletal muscle adaptations that may ultimately contribute to decline in whole-muscle function and, thereby, gait and mobility. For example, intramyocellular fat content in older adults with obesity is associated with larger single fiber cross-sectional area and slower peak shortening velocity and specific power [ 30 , 31 ]. These impairments at the myofibril level subsequently contribute to reduced peak force from individual muscle fibers in persons with compared to those without obesity [ 30 ].…”

Section: Biomechanics and Gait Performancementioning

confidence: 99%

Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty

et al. 2022

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Sarcopenia, defined as the loss of muscle mass, strength, and function with aging, is a geriatric syndrome with important implications for patients and healthcare systems. Sarcopenia increases the risk of clinical decompensation when faced with physiological stressors and increases vulnerability, termed frailty. Sarcopenia develops due to inflammatory, hormonal, and myocellular changes in response to physiological and pathological aging, which promote progressive gains in fat mass and loss of lean mass and muscle strength. Progression of these pathophysiological changes can lead to sarcopenic obesity and physical frailty. These syndromes independently increase the risk of adverse patient outcomes including hospitalizations, long-term care placement, mortality, and decreased quality of life. This risk increases substantially when these syndromes co-exist. While there is evidence suggesting that the progression of sarcopenia, sarcopenic obesity, and frailty can be slowed or reversed, the adoption of broad-based screening or interventions has been slow to implement. Factors contributing to slow implementation include the lack of cost-effective, timely bedside diagnostics and interventions that target fundamental biological processes. This paper describes how clinical, radiographic, and biological data can be used to evaluate older adults with sarcopenia and sarcopenic obesity and to further the understanding of the mechanisms leading to declines in physical function and frailty.

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Quadriceps Lipid Content Has Sex-Specific Associations With Whole-Muscle, Cellular, and Molecular Contractile Function in Older Adults

Cited by 15 publications

References 49 publications

Total and regional body adiposity increases during menopause—evidence from a follow‐up study

Total and regional body adiposity increases during menopause—evidence from a follow‐up study

Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption

Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty

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