QUADAS-2 tool for quality assessment in diagnostic meta-analysis

Huang, Qing-xiu; Huang, Xiaowen

doi:10.21037/apm-22-204

Cited by 6 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of bias and methodological quality of included articles should be independently assessed through the qualitative criteria of Diagnostic Accuracy QUADAS-2 [ 9 , 10 ] and in accordance with the STARD Guidelines [ 11 , 12 ]. Systematic reviews of diagnostic accuracy studies frequently display notably heterogeneous results, stemming from variations in the design and conduct of the encompassed studies.…”

Section: Methodsmentioning

confidence: 99%

Protocol for conducting a systematic review on diagnostic accuracy in clinical research

Sguanci,

Mancin,

Piredda

et al. 2024

MethodsX

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Protocol for conducting a systematic review on diagnostic accuracy in clinical research

Sguanci,

Mancin,

Piredda

et al. 2024

MethodsX

View full text Add to dashboard Cite

“…The quality of the literature was evaluated using the Cochrane risk of bias tool [ 20 , 21 ]. Two reviewers (Wang Ting and Jiang Ruoan) independently screened the literature, extracted the data, and evaluated the quality of the literature according to the inclusion and exclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

Endometrial Cytology in Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis of Diagnostic Accuracy

Wang

Jiang

Yao

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Because the incidence of endometrial cancer has been increasing every year, it is important to identify an effective screening method for it. The endometrial cytology test (ECT) is considered to be the more acceptable technique compared to invasive endometrial sampling. Methods: The study followed the Priority Reporting Project for Systematic Evaluation and Meta-Analysis (PRISMA-DTA) protocol. This systematic rating searched EMBASE and Web of Science databases for studies on ECT for endometrial cancer from the databases’ dates of inception to 30 September 2022. All literature screening and data extraction were performed by two researchers, while the methodological quality of the included studies was assessed against defined inclusion criteria. And a third researcher resolves the disagreements. Results: Twenty-six studies were eventually included in this final analysis. Meta-analysis results showed that the diagnostic accuracy characteristics of ECT for endometrial cancer were as follows: combined sensitivity = 0.84 [95% confidence interval (CI) (0.83–0.86)], combined specificity = 0.98 [95% CI (0.98–0.98)], combined positive likelihood ratio = 34.65 [95% CI (20.90–57.45)], combined negative likelihood ratio = 0.21 [95% CI (0.15–0.30)], and area under the summary receiver operating characteristic curve = 0.9673. Conclusions: ECT had the ability to detect endometrial cancer with strong specificity, although some studies have demonstrated significant differences in sensitivity.

show abstract

“…Methodological quality was evaluated for all-encompassed studies utilizing QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) (20). The QUADAS-2 instrument includes four domainspatient selection, indicator testing, reference standards, and processes and timing, aimed at assessing the risk of bias and clinical applicability of the study.…”

Section: Evaluation Of the Quality Of Included Studiesmentioning

confidence: 99%

miR-29 as diagnostic biomarkers for tuberculosis: a systematic review and meta-analysis

He,

Xiong,

Huang

2024

Front. Public Health

View full text Add to dashboard Cite

BackgroundThe timely diagnosis of tuberculosis through innovative biomarkers that do not rely on sputum samples is a primary focus for strategies aimed at eradicating tuberculosis. miR-29 is an important regulator of tuberculosis pathogenesis. Its differential expression pattern in healthy, latent, and active people who develop tuberculosis has revealed its potential as a biomarker in recent studies. Therefore, a systematic review and meta-analysis were performed for the role of miR-29 in the diagnosis of tuberculosis.MethodsEMBASE, PubMed, CNKI, Web of Science, and Cochrane Library databases were searched utilizing predefined keywords for literature published from 2000 to February 2024.Included in the analysis were studies reporting on the accuracy of miR-29 in the diagnosis of tuberculosis, while articles assessing other small RNAs were not considered. All types of study designs, including case–control, cross-sectional, and cohort studies, were included, whether prospectively or retrospectively sampled, and the quality of included studies was determined utilizing the QUADAS-2 tool. Publication bias was analyzed via the construction of funnel plots. Heterogeneity among studies and summary results for specificity, sensitivity, and diagnostic odds ratio (DOR) are depicted in forest plots.ResultsA total of 227 studies were acquired from the various databases, and 18 articles were selected for quantitative analysis. These articles encompassed a total of 2,825 subjects, primarily sourced from the Asian region. Patient specimens, including sputum, peripheral blood mononuclear cells, cerebrospinal fluid and serum/plasma samples, were collected upon admission and during hospitalization for tuberculosis testing. miR-29a had an overall sensitivity of 82% (95% CI 77, 85%) and an overall specificity of 82% (95% CI 78, 86%) for detecting tuberculosis. DOR was 21 (95% CI 16–28), and the area under the curve was 0.89 (95% CI 0.86, 0.91). miR-29a had slightly different diagnostic efficacy in different specimens. miR-29a showed good performance in both the diagnosis of pulmonary tuberculosis and extrapulmonary tuberculosis. miR-29b and miR-29c also had a good performance in diagnosis of tuberculosis.ConclusionAs can be seen from the diagnostic performance of miR-29, miR-29 can be used as a potential biomarker for the rapid detection of tuberculosis.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=461107.

show abstract

QUADAS-2 tool for quality assessment in diagnostic meta-analysis

Cited by 6 publications

References 6 publications

Protocol for conducting a systematic review on diagnostic accuracy in clinical research

Protocol for conducting a systematic review on diagnostic accuracy in clinical research

Endometrial Cytology in Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis of Diagnostic Accuracy

miR-29 as diagnostic biomarkers for tuberculosis: a systematic review and meta-analysis

Contact Info

Product

Resources

About