Qu’en est-il de la biogenèse des ribosomes chez l’homme ?

Tafforeau, Lionel

doi:10.1051/medsci/20153106015

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…From prokaryotes to mammals, ribosome biogenesis and subsequent translation are highly regulated by the surrounding environment to limit energy expenditure under conditions that are unfavorable for growth, as well as limit the possibility of producing mutant proteins [107,108]. While phosphorylation of eIF2α was long thought to be strictly pro-apoptotic, this is not the case.…”

Section: Eif2α Regulation and Translation Initiation: The Pkr Storymentioning

confidence: 99%

Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster

Piazzi

Bavelloni

Gallo

et al. 2019

IJMS

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Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and, therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not only must ribosomal RNA (rRNA) synthesis, ribosomal protein (RP) transcription, translation, and nuclear import, as well as ribosome assembly, be tightly controlled, these events must be coordinated with other cellular events, such as cell division and differentiation. In addition, ribosome biogenesis must respond rapidly to environmental cues mediated by internal and cell surface receptors, or stress (oxidative stress, DNA damage, amino acid depletion, etc.). This review examines some of the well-studied pathways known to control ribosome biogenesis (PI3K-AKT-mTOR, RB-p53, MYC) and how they may interact with some of the less well studied pathways (eIF2α kinase and RNA editing/splicing) in higher eukaryotes to regulate ribosome biogenesis, assembly, and protein translation in a dynamic manner.

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Section: Eif2α Regulation and Translation Initiation: The Pkr Storymentioning

confidence: 99%

Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster

Piazzi

Bavelloni

Gallo

et al. 2019

IJMS

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“…In eukaryotic cells, ribosomes are composed of 28S, 5S, 5.8S, 18S rRNA and proteins. In ribosomes, the rRNA is the main structural component and the core of structure and function, including (1) Synthesizing amino acids into peptide chains under the guidance of mRNA; (2) Providing binding sites for a variety of protein factors; (3) Having the activity of peptidyl transferase; (4) Providing binding sites for tRNA; (5) Targets of some antibiotics (Korobeinikova et al, 2012;Tafforeau, 2015;Srinivas et al, 2023). These functions are under tight transcriptional control to serve to meet cellular needs.…”

Section: Ribosomal Rna Methylationmentioning

confidence: 99%

Antimicrobial resistance and mechanisms of epigenetic regulation

Wang

2023

Front. Cell. Infect. Microbiol.

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The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicrobial resistance resulting from natural resistance, mutation, gene transfer and other processes. However, the emergence and development of bacterial resistance cannot be fully explained from a genetic and biochemical standpoint. Evolution necessitates phenotypic variation, selection, and inheritance. There are indications that epigenetic modifications also play a role in antimicrobial resistance. This review will specifically focus on the effects of DNA modification, histone modification, rRNA methylation and the regulation of non-coding RNAs expression on antimicrobial resistance. In particular, we highlight critical work that how DNA methyltransferases and non-coding RNAs act as transcriptional regulators that allow bacteria to rapidly adapt to environmental changes and control their gene expressions to resist antibiotic stress. Additionally, it will delve into how Nucleolar-associated proteins in bacteria perform histone functions akin to eukaryotes. Epigenetics, a non-classical regulatory mechanism of bacterial resistance, may offer new avenues for antibiotic target selection and the development of novel antibiotics.

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“…En effet, l'addition de cyclo- c'est-à-dire inhiber la synthèse protéique en libérant l'ARNg des polysomes, créant ainsi une situation favorable à sa réplication. Ceci est étayé par l'utilisation de gradients de polysomes qui montrent que l'addition de miR-122 provoque une réduction de la fraction polysomale au profit de l'émergence de monosomes 80S [16] (➜). Afin de décortiquer le mécanisme moléculaire par lequel miR-122 induit une telle transition, les chercheurs se sont alors intéressés à la protéine PCBP2 (Poly(C) binding protein 2), qui a la particularité de se lier à l'extré-mité 5' de l'ARNg du VHC et de stimuler sa traduction tout en favorisant la « circularisation » du génome viral [11].…”

Section: Nouvelle Mir-122 Continue De Nous Surprendreunclassified

miR-122 continue de nous surprendre

Mengardi

Ohlmann

2015

Med Sci (Paris)

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Qu’en est-il de la biogenèse des ribosomes chez l’homme ?

Cited by 5 publications

References 34 publications

Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster

Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster

Antimicrobial resistance and mechanisms of epigenetic regulation

miR-122 continue de nous surprendre

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