QTc prolongation in patients with hearing loss: Electrocardiographic and genetic study

Sanecka, Agnieszka; Biernacka, Elżbieta Katarzyna; Szperl, Małgorzata; Sosna, Magdalena; Mueller-Malesińska, Małgorzata; Kozicka, Urszula; Baranowski, Rafał; Kosiec, Agnieszka; Łazarczyk, Hubert; Skarżyńśki, Henryk; Hoffmań, Piotr; Bieganowska, Katarzyna; Piotrowicz, Ryszard

doi:10.5603/cj.a2015.0062

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…A 6.4% incidence of postoperative AF was lower than that in other reports [1][2][3][4][5][6]. A significantly wider spQRS-T angle was noted in all of these patients.…”

Section: Discu/ssioncontrasting

confidence: 61%

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Elective lung resection increases spatial QRS-T angle and QTc interval

et al. 2020

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Background: Lung resection changes intra-thoracic anatomy, which may affect electrocardiographic results. While postoperative cardiac arrhythmias have been recognized after lung resection, no study has documented changes in vectorcardiographic variables in patients undergoing this surgery. The purpose of this study was to analyse changes in spatial QRS-T angle (spQRS-T) and corrected QT interval (QTc) after lung resection. Methods: Adult patients undergoing elective lung resection under general anaesthesia were studied. The patients were allocated into four groups: those undergoing (1) left lobectomy (LL); (2) left pneumonectomy (LP); (3) right lobectomy (RL); and (4) right pneumonectomy (RP). The spQRS-T angle and QTc interval were measured one day before surgery (baseline) and 24, 48 and 72 h after surgery. Results: Seventy-one adult patients (47 men and 24 women) aged 47-80 (65 ± 7) years were studied. In the study group as a whole, lung resection was associated with significant increases in spQRS-T (p < 0.001) and QTc (p < 0.05 at 24 and 48 h and p < 0.01 at 72 h). The greatest changes were noted in patients undergoing LP. Postoperative atrial fibrillation (AF) was noted in 6.4% of patients studied, in whom the widest spQRS-T angle and the most prolonged QTc intervals were also noted. Conclusions: Lung resection widens the spQRS-T angle and prolongs the QTc interval, especially in patients undergoing LP. While postoperative AF was a relatively rare complication after lung resection in this study, it was associated with the widest spQRS-T angles and most prolonged QTc intervals.

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“…A 6.4% incidence of postoperative AF was lower than that in other reports [1][2][3][4][5][6]. A significantly wider spQRS-T angle was noted in all of these patients.…”

Section: Discu/ssioncontrasting

confidence: 61%

“…Cardiac arrhythmias, including atrial fibrillation (AF), have been recognized as frequent complications after thoracic surgery [1][2][3][4]. Different kinds of cardiac arrhythmias have been noted in one-fifth of patients after lung resection, AF being the most common [4,5].…”

Section: Introductionmentioning

confidence: 99%

Elective lung resection increases spatial QRS-T angle and QTc interval

et al. 2020

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“…GJB2 located on chromosome 13q encodes for the protein connexin 26 (Cx26), which is involved in potassium ion transport processes necessary for hearing. Mutations of GJB2 impair the transfer of potassium ions within the inner ear, disrupting depolarization which normally leads to the generation of endolymphatic potential—a necessary condition for hearing [Sanecka et al, ]. Abnormalities of GJB2 account for approximately 50% of patients with autosomal recessive HL, which makes it the most common cause of HL in infants.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of evaluation and testing of 660 individuals with hearing loss in a pediatric genetics of hearing loss clinic

Mehta

Noon

Schwartz

et al. 2016

American J of Med Genetics Pt A

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Hearing loss is a relatively common condition in children, occurring in approximately 2 out of every 1,000 births with approximately 50% of reported diagnoses having a primary genetic etiology. Given the prevalence and genetic component of hearing loss, coupled with a trend toward early diagnosis with the institution of universal newborn hearing screening, The Genetics of Hearing Loss Clinic was established at The Children's Hospital of Philadelphia to manage the diagnosis, testing, and genetic counseling for individuals and families. This paper described a cohort of 660 individuals with a diagnosis of hearing loss evaluated between July 2008 and July 2015 in the Genetics of Hearing Loss Clinic. To elucidate the cause of hearing loss in this cohort for better management and prognostication, testing included single nucleotide polymorphism chromosomal microarray, hearing loss next generation sequencing panel, and additional clinical tests inclusive of thyroid and renal function studies, temporal bone magnetic resonance imaging, and electrocardiogram. Of those evaluated, most had bilateral sensorineural hearing loss, occurring in 489/660 (74%). Additionally, 612/660 (93%) of patients presented with a nonsyndromic form of hearing loss (no other observed clinical findings at the time of exam), of which pathogenic mutations in GJB2 were most prevalent. Of the individuals with syndromic manifestations (48/660), Usher and Waardenburg syndrome were most commonly observed. A family history of hearing loss (first degree relative) was present in 12.6% of families with available information. Through molecular analyses, clinical examination, and laboratory testing, a definitive etiologic diagnosis was established in 157/660 (23.8%) of individuals. © 2016 Wiley Periodicals, Inc.

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“…Given the lack of further evidence, we speculate that they died from complications of treatment or some undiagnosed or related diseases. 8,20 We summarize the three possible causes of mortalities in patients with SSNHL as follows: 1) severe complications caused by systemic steroid application (e.g., pheochromocytoma crisis) leading to severe or uncontrollable HT, acute myocardial infarction, pulmonary edema, stroke, organ failure, and even death; 4 2) SSNHL presenting as a local manifestation of an underlying catastrophic illness such as autoimmune disease, antiphospholipid syndrome, cardiovascular disease, leptomeningeal carcinomatosis, or paraneoplastic syndrome; 6,7,[21][22][23][24] and 3) locally aggressive diseases, for example patients with SSNHL dying from large vestibular schwannomas that caused brain herniation and ruptured basilar artery aneurysms. 8,20 Our study has several limitations.…”

Section: Discussionmentioning

confidence: 99%

The association between comorbidities and inpatient mortality with sudden sensorineural hearing loss using a national database in Taiwan

et al. 2020

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The association between comorbidities and inpatient mortality with sudden sensorineural hearing loss (SSNHL) has not been investigated. Therefore, this study aimed to provide a 14-year nationwide incidence, and identify risk factors and comorbidities of SSNHL inpatient mortality. Methods: Data were obtained from the Taiwan National Health Insurance Research Database for 2000 to 2013. Inpatient mortality of 31,258 patients hospitalized with a diagnosis of SSNHL was recorded and analyzed. Results: Sixteen patients with SSNHL exhibited mortality with a percentage of 0.05% and an incidence of less than 0.01 per 100,000 people per year. The risk of variables among inpatient mortality was associated with older age (adjusted odds ratio [OR]: 1.042, 95% confidence interval [CI]: 1.009-1.077) and the presence of catastrophic illness (adjusted OR: 4.949, 95% CI: 1.290-18.996). Potential comorbidities included hematologic diseases, cancers, chronic hepatitis, gastrointestinal bleeding, chronic obstructive pulmonary disease, seizures or convulsions, coronary artery disease, diabetes mellitus, and varicose veins and their associated complications.

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QTc prolongation in patients with hearing loss: Electrocardiographic and genetic study

Abstract: Background: The aim of the study was to determine, whether electrocardiogram (ECG) screening could reduce the risk of sudden cardiac death in patients with (Cardiol J 2016; 23, 1: 34-41)

Cited by 11 publications

References 20 publications

Elective lung resection increases spatial QRS-T angle and QTc interval

Elective lung resection increases spatial QRS-T angle and QTc interval

Outcomes of evaluation and testing of 660 individuals with hearing loss in a pediatric genetics of hearing loss clinic

The association between comorbidities and inpatient mortality with sudden sensorineural hearing loss using a national database in Taiwan

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