QTc prolongation during peripheral stem cell apheresis in healthy volunteers

Korur, Aslı; Kozanoğlu, İlknur; Büyükkurt, Nurhilal; Yeral, Mahmut; Kandemir, Fatih Mehmet; Gereklioğlu, Çiğdem; Sarıtürk, Çağla; Asma, Süheyl; Solmaz, Soner; Boğa, Can; Özdoğu, Hakan

doi:10.1002/jca.21504

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Interestingly, Korur et al 35 showed that QTc prolongation and related complications can develop during leukapheresis, particularly if the procedure takes more than 2 h. One of our patients experienced idiopathic dyspnea, which may be related to the extended apheresis time. Problems with unknown causes during apheresis electrocardiogram records should be checked carefully.…”

Section: Discussionmentioning

confidence: 73%

Autologous peripheral blood stem cell mobilization and apheresis in pediatric patients with cancer: A single‐center report of 64 procedures

Yazal Erdem,

Özyörük,

Ok Bozkaya

et al. 2024

Pediatric Transplantation

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BackgroundThe published experience concerning autologous peripheral blood stem cell collection in children is very limited.MethodsThe data of pediatric patients who underwent autologous stem cell mobilization and apheresis between January 2011 and April 2020 were analyzed retrospectively.ResultsWe studied retrospectively 64 mobilization and apheresis procedures in 48 pediatric patients (34 males, 14 females), mean age of 7.31 ± 5.38 (range, 1.5–19.7) years, the underlying disease was mostly neuroblastoma (NBL). The body weight of 21 patients (43.75%) was 15 kg or less. The targeted autologous peripheral stem cell apheresis (APSCA) was successfully achieved in 98% of patients. Neuroblastoma patients were younger than the rest of the patients and underwent apheresis after receiving fewer chemotherapy cycles than others and all of them mobilized within the first session successfully. Plerixafor was added to mobilization in nine heavily pretreated patients (18.7%), median two doses (range, 1–4 doses). 11 patients (22.9%) underwent radiotherapy (RT) before mobilization with doses of median 24 Gy (range, 10.8–54.0 Gy). Patients with RT were older at the time of apheresis and had received more chemotherapy courses than patients without RT. As a result, patients with a history of RT had significantly lower peripheral CD34+ cells and CD34+ yields than those without RT. In 17 patients (35.4%), 22 different complications were noted. The most common complications were catheter‐related infections (n:10, 20.8%), followed by catheter‐related thrombosis in eight patients (16.7%).ConclusionsPatients who had far less therapy before apheresis were more likely to mobilize successfully. Our study provides a detailed practice approach including complications during APSCA aiming to increase the success rates of apheresis in transplantation centers.

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Section: Discussionmentioning

confidence: 73%

Autologous peripheral blood stem cell mobilization and apheresis in pediatric patients with cancer: A single‐center report of 64 procedures

Yazal Erdem,

Özyörük,

Ok Bozkaya

et al. 2024

Pediatric Transplantation

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“…Various cardiac complications developed easily in cases with QTD prolongation after chemotherapy, in particular, in the hematopoietic cell transplant region [12,22,24,38]. Although studies showing the association between blood collecting flow during leukocyte apheresis and QTD prolongation are limited, hypocalcemia due to citrate has been reported to cause QTc prolongation [10,31,[39][40][41]. Prolongation of QTc is also recognized as a marker of sub-physiological plasma-ionized calcium values and a sensitive marker of citrate toxicity at the myocardial tissue level [31].…”

Section: Discussionmentioning

confidence: 99%

“…The most common complications are related to venous access, vasovagal reactions, hypocalcemia symptoms from the citrate anticoagulant, and allergic reactions in response to replacement fluids [5]. Prophylactic calcium supplementation (to avoid citrate toxicity) and prophylactic antihistamine and/or hydrocortisone are administered as safety procedures [5,10]. However, similar to the demands of blood donation, the patients or donors must be healthy for successful leukocyte apheresis [11].…”

Section: Introductionmentioning

confidence: 99%

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

et al. 2021

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Leukocyte apheresis is necessary in various cellular therapies. However, maintenance of a stable flow rate during leukocyte apheresis is often difficult, even in patients or donors without major problems. Despite this, predictive methods and evidence regarding the reality of the situation are limited. We conducted a retrospective analysis involving adult patients who required leukocyte apheresis for the treatment of neoplasms using WT1-pulsed dendritic cell vaccine.Monocytes were separated from apheresis products to obtain dendritic cells. All the patients were pre-evaluated based on laboratory and chest X-ray findings and subjected to an identical apheresis procedure. The occurrence of poor blood collecting flow during leukocyte apheresis was monitored, and the frequency, clinical information, and associated risk factors were analyzed. Among 160 cases, poor blood collecting flow was observed in 53 cases (33.1%) in a median time of 54 min (range, 2-127 min) post-initiation of leukocyte apheresis. Owing to difficulty in obtaining higher collecting flow, a longer procedure time was required, and in some cases, the scheduled apheresis cycles could not be completed. Consequently, the number of harvested monocytes was low. Multivariable analysis indicated that female patients have an increased risk of poor inlet flow rate. Furthermore, prolonged QT dispersion (QTD) calculated using Bazett's formula was found to be a risk factor. Although the patients did not present any major problems during leukocyte apheresis, poor blood collecting flow was observed in some cases. Sex and pre-evaluated QTD might be useful predictors for these cases; however, further prospective evaluation is necessary.

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Medical and ethical considerations on hematopoietic stem cells mobilization for healthy donors

Moalic-Allain¹

2018

Transfusion Clinique et Biologique

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QTc prolongation during peripheral stem cell apheresis in healthy volunteers

Cited by 4 publications

References 19 publications

Autologous peripheral blood stem cell mobilization and apheresis in pediatric patients with cancer: A single‐center report of 64 procedures

Autologous peripheral blood stem cell mobilization and apheresis in pediatric patients with cancer: A single‐center report of 64 procedures

Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy

Medical and ethical considerations on hematopoietic stem cells mobilization for healthy donors

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