QTc Interval in Individuals with Schizophrenia Receiving Antipsychotic as Monotherapy or Polypharmacy

Elliott, Anja Friis

doi:10.26226/morressier.5885d719d462b8028d89289a

Cited by 1 publication

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“…25 Moreover, the QTc interval is still mainly used to analyse the risk of arrhythmia associated with specific drugs or procedures. 26,27 Second, the small sample size of this study could be a limitation. However, the post-hoc power analysis showed a power of 0.987 when using the mean value of the QTc interval before anaesthetic induction and 90 minutes after pneumoperitoneum.…”

Section: Discussionmentioning

confidence: 96%

Effects of long periods of pneumoperitoneum combined with the head-up position on heart rate-corrected QT interval during robotic gastrectomy: an observational study

et al. 2018

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ObjectivePneumoperitoneum and the head-up position reportedly stimulate the sympathetic nervous system, potentially increasing the risk of cardiac arrhythmia. We evaluated the effects of a long duration of pneumoperitoneum in the head-up position on the heart rate-corrected QT (QTc) interval during robotic gastrectomy.MethodsThis prospective observational study involved 28 patients undergoing robotic gastrectomy. The QTc interval was recorded at the following time points: before anaesthetic induction (baseline); 10 minutes after tracheal intubation; 1, 5, 30, 60, and 90 minutes after pneumoperitoneum induction in the head-up position; after pneumoperitoneum desufflation in the supine position; and at the end of surgery. The primary outcome was the QTc interval, which was measured 90 minutes after pneumoperitoneum combined with the head-up position.ResultsCompared with baseline, the QTc interval was significantly prolonged at 1 and 60 minutes after pneumoperitoneum, peaked at 90 minutes, and was sustained and notably prolonged until the end of surgery. However, no considerable haemodynamic changes developed.ConclusionA long period of carbon dioxide pneumoperitoneum application in a head-up position significantly prolonged the QTc interval during robotic gastrectomy. Therefore, diligent care and close monitoring are required for patients who are susceptible to developing ventricular arrhythmia.Trial Registration: Registered at ClinicalTrials.gov; https://clinicaltrials.gov/ct2/show/NCT02604979; Registration number NCT02604979

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Section: Discussionmentioning

confidence: 96%