QTc interval in a sample of long-term schizophrenia inpatients

Ramos-Ríos, Ramón; Arrojo-Romero, Manuel; Paz-Silva, Eduardo; Carballal-Calvo, Fernando; Bouzón-Barreiro, José L.; Seoane-Prado, Jorge; Codesido-Barcala, Rosario; Crespí-Armenteros, Alicia; Fernández-Pérez, Ramón; López-Moriñigo, Javier-David; Tortajada-Bonaselt, Ignacio; Díaz, Francisco Javier Rodríguez; Leon, José de

doi:10.1016/j.schres.2009.09.041

Cited by 39 publications

(72 citation statements)

References 46 publications

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“…Since cardiovascular disease is an important cause of QT interval prolongation and arrhythmia (Khan et al 1998), this is likely to be a significant factor for QT interval prolongation in the current study. Also, our study showed that female patients had a higher prevalence of QTc prolongation, as well as longer QTc intervals than male patients, which is consistent with previous studies (Vieweg 2002;Lin et al 2004;Sumić et al 2007;Ramos-Ríos et al 2010). However, some studies reported no sex difference in QTc prolongation (Ozeki et al 2010).…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence of QTc prolongation in our sample of 4.5% is in the middle of the reported range (0.5-38%) of existing worldwide prevalence estimates (Ramos-Ríos et al 2010). This relatively low frequency of 4.5% is surprising, taking into account that the patients had a high mean age (50.2± 11.6 years) and a long duration of illness (24.0±11.3 years).…”

Section: Discussioncontrasting

confidence: 40%

“…However, another recent cross-sectional study found that only 10 patients (6%) had a prolonged QTc interval in all inpatients (n=171) in a Spanish long-term psychiatric hospital. After controlling for significant variables, the effects of antipsychotic compound or class on the mean QTc interval were not evident (Ramos-Ríos et al 2010). Thus, the picture emerges that the effects of typical and atypical antipsychotics on QTc prolongation deserve further investigations.…”

Section: Introductionmentioning

confidence: 95%

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Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics

et al. 2011

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 40%

Section: Introductionmentioning

confidence: 95%

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Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics

et al. 2011

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“…In studies by Ng and colleagues, the frequency of aLQTS in a subset of ICU patients who received a known QTc-prolonging medication was 46.6% 25 and 58.4%. 21 Other research [26][27][28][29] on the frequency of aLQTS has focused on patients in units other than ICUs.…”

Section: Discussionmentioning

confidence: 99%

Acquired Long QT Syndrome: Frequency, Onset, and Risk Factors in Intensive Care Patients

Kozik

Wung

2012

Critical Care Nurse

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Background Acquired long QT syndrome is a reversible condition that can lead to torsades de pointes and sudden cardiac death. Objective To determine the frequency, onset, frequency of medications, and risk factors for the syndrome in intensive care patients. Methods In a retrospective chart review of 88 subjects, hourly corrected QT intervals calculated by using the Bazett formula were collected. Acquired long QT syndrome was defined as a corrected QT of 500 milliseconds or longer or an increase in corrected QT of 60 milliseconds or greater from baseline level. Risk factors and medications administered were collected from patients’ medical records. Results The syndrome occurred in 46 patients (52%); mean time of onset was 7.4 hours (SD, 9.4) from time of admission. Among the 88 patients, 52 (59%) received a known QTc-prolonging medication. Among the 46 with the syndrome, 23 (50%) received a known QT-prolonging medication. No other risk factor studied was significantly predictive of the syndrome. Conclusions Acquired long QT syndrome occurs in patients not treated with a known QT-prolonging medication, indicating the importance of frequent QT monitoring of all intensive care patients.

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“…The two groups did not differ at the time of admission in clinical and demographic variables (diagnosis, gender, age, BMI and duration of illness), laboratory values (glucose, total cholesterol, triglycerides and thyroid hormones levels) or psychotropic treatment that could influence the QTc interval length (15 …”

Section: Discussionmentioning

confidence: 88%

The Use of First Generation versus Second Generation Antipsychotics as Add-on or as Switch Treatment and its Effect on QTc Interval: The Italian Experience in a Real-World Setting

Sciascio

Calò

Amodio

et al. 2011

Int J Immunopathol Pharmacol

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Some psychotropic drugs are connected with prolongation of the QT interval, torsade de pointes and sudden death. Recent data suggest that with regard to this adverse effect, the atypical antipsychotic drugs are no safer than the older drugs. The purpose of this study is to evaluate the different use of first generation versus second generation antipsychotics as add-on (Group I) or switch treatment (Group II) and its effect on QTc interval in a sample of schizophrenic and bipolar inpatients without medical illness. All patients had been evaluated twice by using ECG: on admission and after two weeks of hospitalization. Exclusions criteria were: abnormalities in levels of potassium, magnesium and calcium, cardiovascular and metabolic diseases, alcohol or drug abuse. We found a significant (p < 0.01) greater use of first generation antipsychotic in Group I (73.80%) than in the Group II (33.33%). Also Group I showed a significant increase (p < 0.0001) in total chlorpromazine equivalent (476. 78 ± 448.80 mg/day vs 845.48 ± 491.64 mg/day) and in QTc interval (369.14 ± 33.75 ms vs 387.09 ± 31.97 ms), while we did not find any statistical difference in Group II during hospitalization. Our results, in spite of the small sample size, indicate that antipsychotic add-on can increase QTc interval more than switching to other antipsychotic in psychiatric patients without other risk factors.

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QTc interval in a sample of long-term schizophrenia inpatients

Cited by 39 publications

References 46 publications

Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics

Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics

Acquired Long QT Syndrome: Frequency, Onset, and Risk Factors in Intensive Care Patients

The Use of First Generation versus Second Generation Antipsychotics as Add-on or as Switch Treatment and its Effect on QTc Interval: The Italian Experience in a Real-World Setting

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