QTc interval and its variability in patients with schizophrenia and healthy subjects: implications for a thorough QT study

Hingorani, Pooja; Karnad, Dilip R.; Natekar, Mili; Kothari, Snehal; Narula, Dhiraj; Lokhandwala, Yash

doi:10.1017/s1461145712000077

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…This report might indicate the association between NRG1 and QT interval prolongation, as QT interval prolongation is the most widely used surrogate marker for assessing the risk of torsades de pointes (TdP), one of the causes of sudden cardiac death, although the QT interval is considered somewhat imprecise as a surrogate marker for TdP [26]. Furthermore, the present finding that the heart rate of patients with schizophrenia was increased compared to controls is consistent with previous reports [19], [27] and with the finding that the heart rate of mice with impaired NRG1 function was higher than that of control animals [28].…”

Section: Discussionsupporting

confidence: 91%

QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects

et al. 2014

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The potassium voltage-gated channel KCNH2 is a well-known gene in which mutations induce familial QT interval prolongation. KCNH2 is suggested to be a risk gene for schizophrenia. Additionally, the disturbance of autonomic control, which affects the QT interval, is known in schizophrenia. Therefore, we speculate that schizophrenic patients have characteristic features in terms of the QT interval in addition to the effect of antipsychotic medication. The QT interval of patients with schizophrenia not receiving antipsychotics (n = 85) was compared with that of patients with schizophrenia receiving relatively large doses of antipsychotics (n = 85) and healthy volunteers (n = 85). The QT interval was corrected using four methods (Bazett, Fridericia, Framingham or Hodges method). In ANCOVA with age and heart rate as covariates, patients not receiving antipsychotic treatment had longer QT intervals than did the healthy volunteers, but antipsychotics prolonged the QT interval regardless of the correction method used (P<0.01). Schizophrenic patients with and without medication had a significantly higher mean heart rate than did the healthy volunteers, with no obvious sex-related differences in the QT interval. The QT interval prolongation may be manifestation of a certain biological feature of schizophrenia.

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Section: Discussionsupporting

confidence: 91%

QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects

et al. 2014

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“…Schizo group demonstrated a significant increase in mean HR and markedly shorter QTVI compared to controls and relatives groups and there were no statistical differences between last two groups regarding the QTVI values. We concluded that vagal tone might be suppressed and the sympathetic nervous system might show relatively high activity in Schizo group, our results being similar to other studies [9,28].…”

Section: Discussionsupporting

confidence: 91%

Increased QT variability index as a marker for a cardiac autonomic dysregulation in schizophrenia

Costin

Steffen²,

Bär

et al. 2013

2013 E-Health and Bioengineering Conference (EHB)

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Schizophrenia as severe mental disorder is characterized by a disintegration of the process of thinking and of emotional responsiveness whereas the underlying mechanisms of schizophrenia are complex and still discussed. The objective of this study is to find out if patients with schizophrenia and their healthy first-degree relatives have abnormal autonomic nervous system (ANS) activity by measuring cardiac indices as QT variability index (QTVI). Moreover, it is useful to study if ANS dysfunction could play an important role in schizophrenia and if abnormal functioning could be retrieved by patients' healthy first degree relatives. Also, a parallel experiment monitored QTVI in healthy controls before, during and after a new complex stress test named Mannheim Multicomponent Stress Test (MMST). As QT variability analysis results were not significantly different during MMST versus normal state, we concluded that short-term stress has no fundamental impact on ECG morphology in healthy subjects. However, patients with schizophrenia revealed an increased QTVI that indicates structural changes of ECG morphology in those patients. These findings were obviously independent from the findings regarding to healthy subjects under stress and healthy subjects (basic measurement of 30min).

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“…Similar to a previous study, the maximum QT value was found to be extended compared with healthy controls. 24 Although our results did not differ compared with healthy controls at maximum QT value, corrected QTc values (maximum-minimum) and both QT and QTc dispersion values were higher than healthy controls.…”

Section: Discussioncontrasting

confidence: 78%

Electrocardiographic evaluation of the ventricular arrhythmia risk in patients with schizophrenia

Özsoy¹,

Zorlu²,

Kaya³

2021

Anadolu Psikiyatri Derg

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Objective The purpose of this study was to examine electrocardiographic ventricular arrhythmia predictors in patients with schizophrenia by comparing with healthy controls. Methods The study included 100 patients with schizophrenia and 100 healthy controls. Electrocardiography (ECG) was performed on all participants in resting position. T-wave peak to end (Tp-e), QT ranges, P-wave dispersion (Pd), and R-R range were measured. Then, the Schizophrenia Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were applied to the schizophrenia group. Results The PANSS positive symptom subscale was calculated as 10.41 (SD = 2.27), the negative symptom subscale was calculated as 14.44 (SD = 5.42), and the overall functionality level was calculated as 27.04 (SD = 5.43). The mean CDSS score was determined to be 3.74 (SD = 2.15). No differences were detected in the heart rate measurements of the patient and control groups in ECG results ( P = .427). The minimum QT interval and minimum Tp-e wave times were found to be low in the patient group ( P < .001 for both intervals). Corrected QTc dispersion, Pd, Tp-e dispersion, and QT dispersion were found to be higher in the patient group than in healthy controls ( P < .001 for all intervals). Discussion Based on our results, it is possible to speculate that patients with schizophrenia are at a risk of developing cardiac arrhythmia and cardiac dysfunction if they do not receive treatment. For this reason, clinicians should pay attention to cardiac transmission problems when organizing the treatment of patients. Further studies should be conducted to determine cardiac problems in patients with schizophrenia.

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QTc interval and its variability in patients with schizophrenia and healthy subjects: implications for a thorough QT study

Cited by 6 publications

References 27 publications

QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects

QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects

Increased QT variability index as a marker for a cardiac autonomic dysregulation in schizophrenia

Electrocardiographic evaluation of the ventricular arrhythmia risk in patients with schizophrenia

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