QT Variability Index

Dobson, Craig P; Kim, Andrew; Haigney, Mark C.

doi:10.1016/j.pcad.2013.07.004

Cited by 48 publications

(42 citation statements)

References 53 publications

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“…In addition to HRV, temporal fluctuations in ventricular repolarisation can be quantified by measuring beat-to-beat variability in the QT interval [25,26]. The QT variability index (QTVI) is a noninvasive measure of repolarisation lability and has been defined as the ratio of normalised QT variability to normalised HRV; it therefore includes an assessment of autonomic nervous system tone [25].…”

Section: Introductionmentioning

confidence: 99%

“…The QT variability index (QTVI) is a noninvasive measure of repolarisation lability and has been defined as the ratio of normalised QT variability to normalised HRV; it therefore includes an assessment of autonomic nervous system tone [25]. Higher QT variability has been found in patients with cardiovascular disease and is regarded as an indicator of cardiac sympathetic activation and predictor of mortality and sudden death [26].…”

Section: Introductionmentioning

confidence: 99%

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Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

Ziegler

Voss

Rathmann³

et al. 2015

Diabetologia

101

107

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Aims/hypothesis Cardiac autonomic nervous dysfunction (CAND) raises the risk of mortality, but the glycaemic threshold at which it develops is unclear. We aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes. Methods Among 1,332 eligible participants aged 55-74 years in the population-based cross-sectional KORA S4 study, 130 had known diabetes mellitus (k-DM), and the remaining 1,202 underwent an OGTT. Heart rate variability (HRV) and QT variability were computed from supine 5 min ECGs. Results In all, 565 individuals had normal glucose tolerance (NGT), 336 had isolated impaired fasting glucose (i-IFG), 72 had isolated impaired glucose tolerance (i-IGT), 151 had combined IFG-IGT (IFG-IGT) and 78 had newly detected diabetes mellitus (n-DM). Adjusted normal HRV limits were defined in the NGT population (5th and 95th percentiles). Three HRV measures were more frequently abnormal in those with k-DM, n-DM, IFG-IGT and i-IFG than in those with NGT (p<0.05). The rates of CAND (≥2 of 4 HRV indices abnormal) were: NGT, 4.5%; i-IFG, 8.1%; i-IGT, 5.9%; IFG-IGT, 11.4%; n-DM, 11.7%; and k-DM, 17.5% (p<0.05 vs NGT, except for i-IGT). Reduced HRV was associated with cardiovascular risk factors used to construct a simple screening score for CAND. Mortality was higher in participants with reduced HRV (p<0.05 vs normal HRV). Conclusions/interpretation In the general population aged 55-74 years, the prevalence of CAND is increased not only in individuals with diabetes, but also in those with IFG-IGT and, to a lesser degree, in those with i-IFG. It is associated with mortality and modifiable cardiovascular risk factors which may be used to screen for diminished HRV in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

Ziegler

Voss

Rathmann³

et al. 2015

Diabetologia

101

107

View full text Add to dashboard Cite

show abstract

“…Clinically, arrhythmia‐associated cardiac events can be predicted from a high QTVI in adults with an impaired myocardium. However, QTVI shows diurnal variation, and its general use should be assessed in a randomized prospective study (Dobson, Kim, & Haigney, ). In the present study, we used healthy university students as controls to match the control groups used in previous studies (Dobson et al., ; Atiga et al., ; Myredal, Karlsson, & Johansson, ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between QT and JT peak interval variability in prepubertal children

Takeuchi

Omeki

Horio

et al. 2017

Noninvasive Electrocardiol

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“…Pathological alterations to the myocardium result in beat-to-beat action potential duration variability, rendering the myocardium unstable and predisposing it to arrhythmias (Haigney et al, 1998). Prolongation of the QT interval is also seen in cardiomyopathies, which predisposes the myocardium to early after depolarization and may increase transmural dispersion of repolarization, both of which increase the risk of arrhythmias (Akar and Rosenbaum, 2003;Dobson et al, 2013). Therefore, individuals with cardiomyopathies likely demonstrate an increase in QTVI due to a combination of myocardial damage and elevations in sympathetic tone.…”

Section: Discussionmentioning

confidence: 99%

The influence of cardiac autonomic activity on the QT-variability index in able-bodied and incomplete spinal cord injured individuals

Sharif

Cotie

Fountaine

et al. 2015

Autonomic Neuroscience

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QT Variability Index

Cited by 48 publications

References 53 publications

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey

Relationship between QT and JT peak interval variability in prepubertal children

The influence of cardiac autonomic activity on the QT-variability index in able-bodied and incomplete spinal cord injured individuals

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