QT shortening: a proarrhythmic safety surrogate measure or an inappropriate indicator of it?

Tanti, Amy; Micallef, Benjamin; Szijj, Janis Vella; Serracino‐Inglott, Anthony; Borg, John-Joseph

doi:10.1080/03007995.2022.2083401

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…It should be postulate that the presence in therapy of haloperidol and quetiapine might be play a role in the determinism of proarrhythmmic effect. Previous reports [10][11][12] underlined as particularly for haloperidol , the risk of torsades de pointes seemed to be demonstrated especially for women and for intravenously administration. Less dangerous and proved was the effect on QT length for quetiapine, that seemed to determinate a QT shortening that might be also considered an indicator of proarrhythmic effect.…”

Section: Discussionmentioning

confidence: 95%

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Gonella,

Casile,

Menardi

et al. 2024

Preprint

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Although cardiac resynchronization therapy (CRT) reduces morbidity and mortality and reverses left ventricular (LV) remodeling in heart failure patients with LV electrical dyssynchrony, induced proarrhythmia has been reported. The mechanism of CRT-induced proarrhythmia remains under debate. In this case report, a description of how a LV pacing induced polymorphic ventricular tachycardia immediately after the initiation of CRT has been reported. Changing the pacing configuration using a multipoint pacing stimulation, we can assume that VTs induced are related to the reentry mechanism facilitated by the unidirectional block. As a result, MPP pacing configuration near the scar area avoid the onset of a unidirectional block with the establishment of the reentry phenomenon thus avoiding induced VTs.

show abstract

Section: Discussionmentioning

confidence: 95%

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Gonella,

Casile,

Menardi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…It should be postulate that the presence of haloperidol and quetiapine in therapy might be play a role in the determinism of the proarrhythmic effect. Previous reports [11][12][13] underlined that the risk of torsades de pointes seemed was demonstrated, especially for women and for intravenously administration, particularly in regards to haloperidol. Less dangerous was the proven influence of quetiapine on QT length, which seemed to determine a QT shortening that might also be considered an indicator of the proarrhythmic effect.…”

Section: Discussionmentioning

confidence: 99%

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Gonella,

Casile,

Menardi

et al. 2024

Diseases

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Although cardiac resynchronization therapy (CRT) reduces morbidity and mortality and reverses left ventricular (LV) remodeling in heart failure patients with LV electrical dyssynchrony, induced proarrhythmia has been reported. The mechanism of CRT-induced proarrhythmia remains under debate. In this case report, a description of how LV pacing induced polymorphic ventricular tachycardia immediately after the initiation of CRT has been reported. By changing the pacing configuration using a multipoint pacing stimulation, we can assume that induced ventricular tachycardia is related to the reentry mechanism facilitated by the unidirectional block. As a result, a multipoint pacing (MPP) configuration near the scar area can avoid the onset of a unidirectional block with the establishment of the reentry phenomenon, thus avoiding induced VTs.

show abstract

Multiple drugs

2023

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QT shortening: a proarrhythmic safety surrogate measure or an inappropriate indicator of it?

Cited by 3 publications

References 23 publications

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Electrical Storm Induced by Cardiac Resynchronization: Efficacy of the Multipoint Pacing Stimulation

Multiple drugs

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