QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.

Schouten, Evert G.; Dekker, Joost; Meppelink, P.; Kok, F.J.; Vandenbroucke, Jan P.; Pool, J.

doi:10.1161/01.cir.84.4.1516

Cited by 568 publications

(398 citation statements)

References 32 publications

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“…In the patients with Long QT syndrome and healthy population, prolonged QT interval predicts ventricular arrhythmias and sudden death [15,16]. QT dispersion on a standard 12-lead ECG is a marker of variability of ventricular repolarization.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of QT dispersion in β thalassaemia major patients

et al. 2006

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Cardiac complications are considered to be the primary cause of death in patients with b thalassaemia major. QT dispersion is a marker variability of ventricular repolarization and is elevated in various high risk groups of patients. This study was carried out in patients with b thalassaemia major to evaluate QT dispersion and to investigate the relationship between QT dispersion and body iron load. Sixty-two b thalassaemia major patients were enrolled into the study. The average serum ferritin levels and liver iron concentration was assessed. For each patient, QTQTc intervals and QT-QTc dispersions were calculated and V1S and V5R were measured. All the subjects underwent two-dimensional M mode echocardiogram and Doppler study. LVMI was found higher in thalassaemia major patients compared to control group. b thalassaemia major patients showed significantly higher mean QT, QTc, QTd, and QTcd values compared to the control group. The mean V5R and V1S amplitudes were also higher in b thalassaemia major patients. There was a positive correlation between LVMI and QTc, QTd and QTcd. However, there was no significant correlation between QT dispersion and serum ferritin and liver iron concentration. Prospective longitudinal studies are needed to assess the prognostic significance of these findings. Am. J. Hematol. 81:901-906, 2006. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Evaluation of QT dispersion in β thalassaemia major patients

et al. 2006

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“…QTc was considered prolonged when 4440 ms, in accordance with the criteria commonly used in the literature. 5,10 QTd was calculated as maximum QT interval minus minimum QT interval in any of the leads. Since it does not depend on the heart period in the same way as the QT interval, QTd was not corrected with Bazett's formula.…”

Section: Methodsmentioning

confidence: 99%

“…8,9 Among the elderly and in healthy populations, subjects with a prolonged QTc show an increased risk for coronary heart disease and cardiac mortality. 10,11 In the Zutphen Study 12 the risk for cardiac mortality associated with a prolonged QTc increases two-to four-fold in middle-aged men and three-fold in elderly men.…”

Section: Introductionmentioning

confidence: 99%

Relationship between QT interval and cardiovascular risk factors in healthy young subjects

et al. 2005

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A prolongation of QT interval increases the risk for coronary heart disease, ventricular arrhythmias, and sudden death in diabetic patients, after myocardial infarction, and in the elderly. An association between QT prolongation and cardiovascular risk factors has been demonstrated in middle-aged and elderly subjects. Aims of this study were to evaluate the prevalence of a prolonged corrected QT interval (QTc) in a healthy young population (n ¼ 170, age 22-25 years, 84 males) and to investigate the association of QTc and QT dispersion (QTd) with cardiovascular risk factors (body mass index, blood pressure, fasting blood glucose and cholesterol, smoking habits, and hypertensive familiarity). A prolonged QTc was observed in 10% of female and 5% of male subjects; in multiple regression analysis, QTc showed a significant positive relationship with blood glucose in females (P ¼ 0.04) and systolic blood pressure in male subjects (P ¼ 0.03), while QTd was not significantly related with any of the factors.In conclusion, the association between QTc length, glucose levels, and blood pressure is present also in young healthy subjects. QT measurement may represent a useful marker in the screening of young subjects for cardiovascular prevention.

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“…A more recent analysis from the same cohort reports that prolonged QTc interval was an independent risk factor for sudden cardiac death in older adults followed for 6.7 years (72,73). QTc interval was also found to be a predictor of increased overall cardiovascular morbidity and mortality in several cohort studies (74)(75)(76)(77)(78). There is significant potential for prolonged cardiac repolarization to enhance risk stratification for sudden cardiac death among unrelated individuals in the general population and it clearly merits further evaluation.…”

Section: Prolonged Ventricular Repolarization and Risk Of Sudden Cardmentioning

confidence: 97%

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

Progress in Cardiovascular Diseases

595

458

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The current annual incidence of sudden cardiac death in the US is likely to be in the range of 180-250,000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the US during the second half of the twentieth century. However the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the US and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.

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QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.

Abstract: Background. In myocardial infarction patients, heart rate-adjusted QT interval (QT), an electrocardiographic indicator of sympathetic balance, is prognostic for survival.

Cited by 568 publications

References 32 publications

Evaluation of QT dispersion in β thalassaemia major patients

Evaluation of QT dispersion in β thalassaemia major patients

Relationship between QT interval and cardiovascular risk factors in healthy young subjects

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

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