QT interval measurement in ventricular pacing: Implications for assessment of drug effects and pro-arrhythmia risk

Schurr, James W.; Grewal, Prabhjot; Fan, Roger; Rashba, Eric J.

doi:10.1016/j.jelectrocard.2021.11.029

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Cited by 3 publications

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“…The QTc is prolonged at 0.50 seconds. While the QTc accounts for variations in heart rate, it may not be an accurate measure in paced rhythms with wide QRS complexes 4…”

Section: Discussionmentioning

confidence: 99%

A Case of a Presurgical Abnormal Rhythm

Kupchik,

Wallace

2024

AJN, American Journal of Nursing

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“…The QTc is prolonged at 0.50 seconds. While the QTc accounts for variations in heart rate, it may not be an accurate measure in paced rhythms with wide QRS complexes 4…”

Section: Discussionmentioning

confidence: 99%

A Case of a Presurgical Abnormal Rhythm

Kupchik,

Wallace

2024

AJN, American Journal of Nursing

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“…Moreover, reduction in HRV is associated with higher risk of SUDEP ( 28 ). Prolongation of the QT interval may be an important cause of ventricular arrhythmias in epileptic patients ( 29 ). Chahal et al ( 17 ) reported that a prolonged QT interval in epileptic patients was associated with increased mortality.…”

Section: Sudep Mechanismsmentioning

confidence: 99%

The mechanism of sudden unexpected death in epilepsy: A mini review

Sun

Jiang

2023

Front. Neurol.

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Sudden unexpected death in epilepsy (SUDEP) is defined as a sudden, unexpected, non-traumatic, non-drowning death in a person with epilepsy. SUDEP is generally considered to result from seizure-related cardiac dysfunction, respiratory depression, autonomic nervous dysfunction, or brain dysfunction. Frequency of generalized tonic clonic seizures (GTCS), prone posture, and refractory epilepsy are considered risk factors. SUDEP has also been associated with inherited cardiac ion channel disease and severe obstructive sleep apnea. Most previous studies of SUDEP mechanisms have focused on cardiac and respiratory dysfunction and imbalance of the neural regulatory system. Cardiac-related mechanisms include reduction in heart rate variability and prolongation of QT interval, which can lead to arrhythmias. Laryngospasm and amygdala activation may cause obstructive and central apnea, respectively. Neural mechanisms include impairment of 5-HT and adenosine neuromodulation. The research to date regarding molecular mechanisms of SUDEP is relatively limited. Most studies have focused on p-glycoprotein, catecholamines, potassium channels, and the renin-angiotensin system, all of which affect cardiac and respiratory function.

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