QT dispersion and risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy

Yan, Gang; Elliott, Perry; McKenna, William J.; Prasad, Krishna; Sharma, Sanjay; Guo, Xiang-Zhao; Malík, Marek

doi:10.1016/s0002-9149(98)00696-1

Cited by 63 publications

(45 citation statements)

References 28 publications

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“…Currently available studies report controversial results regarding QTd and prognosis in HCMP. QTd (14) and QT prolongation (15) have been reported in HCMP previously. Maron et al (16) found that QT dispersion has no prognostic value in term of sudden death in patients with HCMP.…”

Section: Introductionmentioning

confidence: 63%

“…Although, there are many controversial studies on it's prognostic value (14)(15)(16)(17)(18), QT dispersion is supposed to be clinically important measure for heart diseases. Both QT dispersion and corrected OT dispersion are accepted as an indicator of arrhythmic events and general abnormality of repolarization (20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…One of these changes of ECG waves is QT dispersion. QT dispersion (QTd) (14)(15)(16)(17) have been used previously as noninvasive prognostic tools in the evaluation and risk stratification of HCMP patients. Currently available studies report controversial results regarding QTd and prognosis in HCMP.…”

Section: Introductionmentioning

confidence: 99%

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The variations of BOP gene in hypertrophic cardiomyopathy

Abacı¹,

Güleç²,

Bayrak³

et al. 2010

Anadolu Kardiyol Derg

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Hipertrofik kardiyomiyopatide BOP geni varyasyonları 303ÖZET Amaç: Bop mutant farelerde, az gelişmiş sağ ventrikül ve aşırı büyümüş sol ventrikül varlığı, insan BOP geni ile hipertrofik kardiyomiyopati (HKMP) arasında olası bir ilişkiyi düşündürmektedir. Bu çalışmamızda, BOP genindeki varyasyonlar ile HKMP için noninvazif bir aritmik risk göstergesi olan QT dispersiyonu arasındaki olası ilişkiyi araştırdık. Yöntemler: Enine-kesitli niteliğindeki çalışmaya 50 HKMP'li hasta ve 60 sağlıklı kontrol alındı. BOP geni ekson bölgeleri, polimeraz zincir reaksiyonu (PCR) ile çoğaltıldı ve çoğaltılan ekson bölgeleri, Tek İplikli Konformasyon Polimorfizm (SSCP) analizi ile incelendi. Farklı bantlara sahip örnekler otomatik dizileme yöntemi kullanılarak dizilendi. Sürekli değişkenler eşleştirilmemiş bağımsız örneklem t-testi ya da Mann-Whitney U testi ile karşı-laştırıldı. Genotip-hastalık ilişkisi Ki-kare testi ile test edildi. Bulgular: Ekson 2 ve 7'deki G275>A ve C965>A tek nükleotid değişimleri (TND) sadece HK grubunda belirlendi. Ekson 6 ve 9'daki G707>C, C710>T, T761>C, T1217>C TND'lerine kontrol grubunda da rastlandı. İki grup arasındaki fark ise anlamlı bulundu (p=0.002 ve p<0.001). Ekzon 6'daki TND'lerin haplotip oluşturduğu ve bu haplotipin nadir alleli (707C/710T/761C) için homozigot taşıyıcı olan HK hastalarında QT dispersiyonu ve düzeltilmiş QT dispersiyonu, diğer genotiplere göre anlamlı derecede düşük bulundu (p=0.032 ve p=0.030). Sonuç: Bu çalışma, insanda BOP geni ile HKMP arasındaki ilişkiyi araştıran ilk çalışmadır. Üç farklı TND'yi içeren 707C/710T/761C haplotip takımını taşıyan HK'li olgularda QT dispersiyonu ve düzeltilmiş QT dispersiyonunun anlamlı derecede uzamış bulunması, BOP genindeki bu haplotipin ventikü-ler aritmilerle ve dolayısı ile ani ölümle ilişkili olabileceğini akla getirmektedir. (Anadolu Kardiyol Derg 2010; 10: 303-9) Anah tar ke li me ler: BOP, hipertrofik kardiyomiyopati, klinik farklılık, modifiye edici gen, genetik varyasyon, QT dispersiyonu ABSTRACT Objective: The observation that Bop null allele mice show underdeveloped right ventricle and excessive development of left ventricle, suggests the possible relationship between human BOP gene and hypertrophic cardiomyopathy (HCMP). In our study, we investigated this possible relationship between BOP gene variations and QT dispersion, a noninvasive arrhythmic risk marker for HCMP. Methods: This cross-sectional study consisted of 50 patients clinically diagnosed with HCMP and 60 healthy subjects. Exonic regions of BOP gene were amplified by polymerase chain reaction and amplified exonic regions were analyzed by Single-Strand Conformation Polymorphisms (SSCP). The samples with different migration patterns were sequenced through an automated sequencing system. Continuous variables were compared by unpaired t-test for independent samples or Mann-Whitney U test. Genotype-disease relationship was tested by Chi-square test. Results: The nucleotide substitutions G275>A and C965>A in exon 2 and 7 were determined only in HCMP group. The G707>C, C7...

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Section: Introductionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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The variations of BOP gene in hypertrophic cardiomyopathy

Abacı¹,

Güleç²,

Bayrak³

et al. 2010

Anadolu Kardiyol Derg

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“…The mechanism of the VT was determined to be reentry which is often caused by myocardial fibrosis or fatty infiltration as a result of infarction or cardiomyopathy. Myocardial fibrosis is thought to possibly cause spatial dispersion of the cardiac impulse supporting reentrant arrhythmias (Dritsas et al 1992;Yi et al 1998;Shirani et al 2000;McDowell et al 2008). Tada et al speculated that the glycogen accumulation in the heart may have led to a ventricular conduction delay which drove the reentrant circuit and thereby caused the VT.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Pathology in Glycogen Storage Disease Type III

et al. 2012

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Purpose: To investigate the distribution and clinical impact of glycogen accumulation on heart structure and function in individuals with GSD III.Methods: We examined cardiac tissue and the clinical records of three individuals with GSD IIIa who died or underwent cardiac transplantation. Of the two patients that died, one was from infection and the other was from sudden cardiac death. The third patient required cardiac transplantation for end-stage heart failure with severe hypertrophic cardiomyopathy.

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“…Electrocardiographic (ECG) parameters have been studied for their utility as prognostic non-invasive markers in sudden cardiac death (SCD) risk assessment. The prolongation of the frequency corrected QT interval (QTc) and increased QTc dispersion (characterizing spatial repolarization heterogeneity) were observed in patients with hypertrophic cardiomyopathy (HCM) [Buja et al 1993;Dritsas et al 1992;Yi et al 1998]. However, QTc prolongation and QTc dispersion have been found not to be predictive for SCD in HCM patients [Yi et al 1998;Maron et al 2001].…”

Section: Introductionmentioning

confidence: 99%

Analysis of short-term temporal variability of cardiac ventricular repolarization in subjects with different clinical conditions

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QT dispersion and risk factors for sudden cardiac death in patients with hypertrophic cardiomyopathy

Cited by 63 publications

References 28 publications

The variations of BOP gene in hypertrophic cardiomyopathy

The variations of BOP gene in hypertrophic cardiomyopathy

Cardiac Pathology in Glycogen Storage Disease Type III

Analysis of short-term temporal variability of cardiac ventricular repolarization in subjects with different clinical conditions

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