QT dispersion and acute cerebrovascular accident

Önder, Halil; Hanalıoğlu, Şahin

doi:10.4103/0976-3147.185503

Cited by 1 publication

(2 citation statements)

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“…It consists of four basic cellular elements: endothelial cells, astrocytes, pericytes, and the base membrane. 22 Various approaches have been studied for the delivery of anticonvulsant drugs directly into the central nervous system for the treatment of epileptic seizures. 9 Many other direct drug delivery systems require a specific technique that is used to prevent the distribution of seizures in specific or other hemisphere regions of the brain.…”

Section: Movement Of Nanoparticles Across the Blood-brain Barriers (Bbb)mentioning

confidence: 99%

“…Antiepileptic medicinal products are normally administered by intravenous and oral routes. 22 Several biological factors significantly reduce the entry of drugs to the brain, especially the BBB, which disrupts the potency of the drug molecule to reach and remain inside the brain. 27 Advanced nanotechnology techniques are helping to improve the entry of nanomaterials into the brain, especially in the case of emergency conditions.…”

Section: Enhancement Of Aeds Delivery To the Brainmentioning

confidence: 99%

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Therapeutic Approaches of Nanotechnology for Epileptic Seizures: A Comprehensive Review of Current Knowledge

Shrivastava¹,

Gupta²,

Goyal³

2022

IJPER

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Epilepsy is a chronic neurological condition in which several neurotransmitters act like neuromodulators. The symptoms of epilepsy are caused by abnormal electrical discharges in a group of neurons in the hippocampus region of the brain. This can also affect electrical impulse generation, either in the focal area or in the hippocampus region of the brain. This review aimed to develop a better understanding of the transportation of nanoparticles across the blood-brain barrier and how to enhance the delivery of the drug in epileptic conditions by the utilization of nanomaterials. A few clinical studies have reported that antiepileptic drugs are generally used for the treatment of epilepsy by decreasing the frequency and intensity of seizures or preventing tissue damage in the brain. In longterm therapy, antiepileptic drugs are primarily administered via the oral route, but they are not always beneficial. Therefore, intravenous routes are especially used in serious epileptic conditions. In this review, we discussed the drug delivery study of antiepileptic drugs that are used in the form of nanoparticles that can easily be transported across the blood-brain barrier. Besides, the nanoparticles can easily cross the blood-brain barrier and increase the uptake into the target cells. Drug absorption into the brain is substantially limited by some factors, especially in the blood-brain barrier, which affects the potency of antiepileptic drugs to reach and remain inside the brain. Novel drug delivery systems have already been studied in many clinical trials to enhance the therapeutic efficacy of antiepileptic drugs in epileptic conditions.

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Section: Movement Of Nanoparticles Across the Blood-brain Barriers (Bbb)mentioning

confidence: 99%

Section: Enhancement Of Aeds Delivery To the Brainmentioning

confidence: 99%