QT correction in atrial fibrillation – Measurement revisited

Dash, A. P.; Torado, Cyril L.; Paw, Nieman; Ding, Fan; Pezeshkian, Nayereh G; Srivatsa, Uma N.

doi:10.1016/j.jelectrocard.2019.06.009

Cited by 17 publications

(17 citation statements)

References 9 publications

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“…The regression analysis (including age, sex, and history of cardiac disease) did not show an independent association between QTc and total active moiety serum concentration (F= −0.60, df=1, p=0. 44), and none of the potential confounders were significant mediators.…”

Section: Ecg Parametersmentioning

confidence: 84%

“…Thus, we were unable to account for rhythms such as atrial fibrillation or bundle branch blocks, which can impact the accuracy of QTc calculations. However, some studies suggest that the QTc Fridericia formula we used is an appropriate formula for determining QTc in atrial fibrillation 44,45 . Finally, the generalizability of the results is limited to older individuals in their 60's and 70's whose medical comorbidities were stable enough to have participated in and completed our clinical trial.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults

Behlke¹,

Lenze²,

Pham³

et al. 2020

J Clin Psychopharmacol

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Purpose/ Background: Venlafaxine is a commonly used antidepressant with both serotonergic and noradrenergic activity. There are concerns it may prolong the corrected QT interval (QTc), and older adults may be at higher risk for this adverse effect, especially at higher dosages of the medication. Methods/Procedures:In this secondary analysis of a prospective clinical trial, we measured changes in QTc and other ECG parameters in 169 adults aged ≥ 60 with a major depressive disorder treated acutely with venlafaxine extended release (XR) up to 300 mg daily. We examined the relationship of venlafaxine dosage and ECG parameters, as well as the relationship between serum levels of venlafaxine and ECG parameters.Findings/Results: Venlafaxine exposure was not associated with an increase in QTc. Heart rate increased with venlafaxine treatment, while the PR interval shortened, and QRS width did not change significantly. QTc change from baseline was not associated with venlafaxine dosages or

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Section: Ecg Parametersmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults

Behlke¹,

Lenze²,

Pham³

et al. 2020

J Clin Psychopharmacol

View full text Add to dashboard Cite

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“…The QT interval was defined as the time duration between the earliest QRS onset to the latest T-wave offset in the 12 ECG leads. For calculation of QTc interval, Fridericia's formula was used because it has been regarded as being appropriate for calculating QTc interval in patients with tachycardia or bradycardia ( 17 ), or AF due to the beat-to-beat variability in the RR interval ( 18 , 19 ). QTc intervals were calculated by a specialized cardiologist and stratified by quartiles for each sex.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Significance of Prolonged Corrected QT Interval in Acute Ischemic Stroke

et al. 2021

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Background and Purpose: The aim of this study was to determine the relationship between the heart rate-corrected QT (QTc) interval and the risk of incident long-term mortality in patients with acute ischemic stroke (AIS), considering the impact of sex differences on clinical characteristics, outcomes, and QTc intervals.Methods: We analyzed prospectively registered data included patients with AIS who visited the emergency room within 24 h of stroke onset and underwent routine cardiac testing, such as measurements of cardiac enzymes and 12-lead ECG. QTc interval was corrected for heart rate using Fridericia's formula and was stratified by sex-specific quartiles. Cox proportional hazards models were used to examine the association between baseline QTc interval and incident all-cause death.Results: A total of 1,668 patients with 1,018 (61.0%) men and mean age 66.0 ± 12.4 years were deemed eligible. Based on the categorized quartiles of the QTc interval, cardiovascular risk profile, and stroke severity increased with prolonged QTc interval, and the risk of long-term mortality increased over a median follow-up of 33 months. Cox proportional hazard model analysis showed that the highest quartile of QTc interval (≥479 msec in men and ≥498 msec in women; hazard ratio [HR]: 1.49, 95% confidence interval [CI]: 1.07–2.08) was associated with all-cause death. Furthermore, dichotomized QTc interval prolongation, defined by the highest septile of the QTc interval (≥501 ms in men and ≥517 m in women: HR: 1.33, 95% CI: 1.00–1.80) was significantly associated with all-cause mortality after adjusting for all clinically relevant variables, such as stroke severity.Conclusions: Prolonged QTc interval was associated with increased risk of long-term mortality, in parallel with the increasing trend of prevalence of cardiovascular risk profiles and stroke severity, across sex differences in AIS patients.

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“…The 12-lead ECGs ( lter range 0.05 to 150Hz; AC lter 50Hz, 25mm/s, 10mm/mV) were evaluated by two independent senior electrophysiology experts from the Cardiac Arrhythmia Center of Fuwai Hospital, who were blinded to the clinical, pathological and genetic information. QT correction in atrial brillation was measured as previously reported 8 . Patients with pacemaker implantation were excluded from ECG measurement.…”

Section: Electrocardiographymentioning

confidence: 99%

Ultrastructural analysis of cardiomyocytes shows that loss of left ventricular desmosomes leads to shortening of ST segment time in patients with arrhythmogenic cardiomyopathy

Chang

Hua

et al. 2020

Preprint

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Background: Arrhythmogenic cardiomyopathy (AC) is an inherited myocardial disease affecting the both ventricles. It shows large heterogeneity on its clinical, genetic, and pathological manifestations. The intercalated disc remodeling has been investigated in right ventricle (RV) of AC, however, the ultrastructural features in left ventricle (LV) and among different genotypes remain unknown.Methods: The ultrastructure characters of both ventricles from 24 AC who fulfilled the international Task Force diagnostic and 10 normal donor hearts were studied by transmission electron microscope. We applied Pearson correlation analysis to identify the relationship between D structure and electrocardiogram changes.Results: These 24 patients were divided into two subtypes based on whether they carried desmosome (D) gene mutation. We found that more D structures in LV than that in the right ventricles (RV) in the normal hearts (LV vs. RV, 10.82 ± 3.12% vs. 6.75 ± 1.11%, p=0.001), but the density (AC vs. Control, 3.77 ± 1.58 per 10 μm vs. 4.21 ± 1.76 per 10 μm, p=0.001) and proportion (AC vs. Control, 6.65 ± 2.77% vs. 10.82 ± 3.12%, p=0.001) of D was declined in LV of AC compared with that in normal hearts. The width (AC vs. Control, 21.38 ± 2.31 nm vs. 18.09 ± 0.98 nm, p=0.001) and length (AC vs. Control, 0.17 ± 0.05 μm vs. 0.14 ± 0.01 μm, p=0.002) of D was increased in RV of AC compared with that in normal hearts. Destroyed D structures were found in all AC patients, regardless of carrying a D gene mutation or not. The proportion of D in LV are positively correlated with ST segment time in AC patients. The ultrastructure of mitochondria was not different between AC and normal hearts.Conclusions: The D remodeling patterns had no correlation with the type of mutation. The D of LV mainly showed a decrease in density and proportion, but the D of RV were mainly manifested as compensatory widening and lengthening. The D loss in LV may cause ST segment shortening. From the perspective of ultrastructure, we concluded that increased output power of heart may accelerate the desmosome remodeling or disintegration.

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QT correction in atrial fibrillation – Measurement revisited

Cited by 17 publications

References 9 publications

The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults

The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults

Prognostic Significance of Prolonged Corrected QT Interval in Acute Ischemic Stroke

Ultrastructural analysis of cardiomyocytes shows that loss of left ventricular desmosomes leads to shortening of ST segment time in patients with arrhythmogenic cardiomyopathy

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