QSAR study of the peptidic fibrinogen inhibitors FK633, FR158999 and related derivatives, using a novel and useful hydrophobic descriptor (logPmw)

Tanaka, Akito; Murata, Masayoshi; Fujiwara, Hideaki

doi:10.1016/s0960-894x(98)00405-3

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Quantitative Retention-(biological) Activity Relationships (...1

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2007

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“…Lipophilicity parameters from MLC were also reported to correlate with specific bioactivity data by other authors who applied their own procedures. In 1998, Tanaka et al obtained in this way a description of fibrinogen inhibitory activities of peptide compounds. Detroyer et al correlated with MLC retention parameters the cellular permeability coefficients in Caco-2 monolayers and apparent permeability coefficients in rat intestinal segments for β-adrenoceptor anatagonists.…”

Section: Quantitative Retention-(biological) Activity Relationships (...mentioning

confidence: 99%