QSAR of Acute Toxicity of 1,4-Di-Substituted Benzene Derivatives and Relationships with the Acute Toxicity of Corresponding Mono-Substituted Benzene Derivatives

Kaiser, Klaus L.E.

doi:10.1007/978-94-009-3937-0_14

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Water saturated solutions were prepared, the compounds were added to water, and the water saturated fraction collected with a separatory funnel. The amount of compound present in the water was determined from QSAR data [10,11]. Finally, the volume required to make a solution with 1,000 ppm (1,000 mg l -1 ) was added to water and this mixture assayed.…”

Section: Toxicity Of Organic Chemicalsmentioning

confidence: 99%

A simple, rapid, inexpensive assay for toxic chemicals using a bacterial indicator

Botsford

1997

Global Environmental Biotechnology, Proceedings of the Third Biennial Meeting of the International Society for Environmental Bi

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Section: Toxicity Of Organic Chemicalsmentioning

confidence: 99%

A simple, rapid, inexpensive assay for toxic chemicals using a bacterial indicator

Botsford

1997

Global Environmental Biotechnology, Proceedings of the Third Biennial Meeting of the International Society for Environmental Bi

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Photobacterium phosphoreum toxicity bioassay. II. Toxicity data compilation

Kaiser¹,

Ribo

1988

Environ. Toxicol. Water Qual.

111

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This review of Photobacterium phosphoreum toxicity bioassay, commonly known as the Microtox tests, consists of two parts. This second part (Toxicity Data Compilation) is a listing of all published and certain unpublished Microtox toxicity data for single organic compounds, including some salts and organometallic compounds. This listing consists of three tables: the first provides the reference source, toxicity value(s), chemical formula, name, the Chemical Abstracts Service (CAS) and Registry of Toxic Effects of Chemical Substances (RTECS) accession numbers, and molecular weight of each compound. At present, this table contains approximately 500 entries, which are ordered by the compounds' molecular formula. Two additional tables, ordered accordingly, are intended to provide quick access through cross‐references with the CAS and RTECS numbers, respectively.

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Classification of Contaminants by Mode of Action Based onin vitroAssays

Nendza¹,

Wenzel²,

Wienen³

1995

SAR and QSAR in Environmental Research

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A concept for toxicity assessments based on in vitro assays of variant levels (i.e., from whole cells to isolated enzymes) is presented. Due to the complexity of organisms of different species, it is evident that no single in vitro test can represent the entire spectrum of toxic potency of chemicals, rather a carefully designed battery of tests has to be employed to account for the various targets attacked in organisms yielding the different modes of action. Cytotoxicity tests like the Neutral-Red Assay predominantly reflect non-specific toxicity, which can be modelled according to a log Pow dependent baseline QSAR. Specific toxicants (e.g., decouplers, acetylcholinesterase inhibitors or photosystem II inhibitors) may be identified based on according in vitro tests and eventually modelled by the respective mode of action related QSARs employing also, e.g., steric or polarizability descriptors to account for specific interactions. The complementation and partial replacement of in vivo (eco)toxicological testing by in vitro assays depends on two criteria: (a) the sensitivity of the tests to reliably detect environmentally relevant concentrations of toxicants and (b) the specificity of the assays to provide an unambiguous classification of toxicants by modes of action: the pattern of interaction with the various targets allows to recognize those compounds of specific effects that frequently occur as outliers in QSAR analyses.

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QSAR of Acute Toxicity of 1,4-Di-Substituted Benzene Derivatives and Relationships with the Acute Toxicity of Corresponding Mono-Substituted Benzene Derivatives

Cited by 4 publications

References 12 publications

A simple, rapid, inexpensive assay for toxic chemicals using a bacterial indicator

A simple, rapid, inexpensive assay for toxic chemicals using a bacterial indicator

Photobacterium phosphoreum toxicity bioassay. II. Toxicity data compilation

Classification of Contaminants by Mode of Action Based onin vitroAssays

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