QSAR models for describing the toxicological eﬀects of ILs against Candida albicans based on norm indexes

Yan, Fangyou; He, Wensi; Jia, Qi; Wang, Qiang

doi:10.1016/j.chemosphere.2018.02.147

Cited by 22 publications

(2 citation statements)

References 54 publications

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“…In this work, the model developed (also using LFER predictors) presented an R 2 = 0.901 with an SE of 0.426. Instead of using LFER descriptors, Yan and coworkers [ 83 ] decided to apply matrix norm and topological indexes to develop two new QSAR models to predict the antifungal activity of ILs against C. albicans . A total of 141 MIC and 85 MBC experimental data of ILs against C. albicans were collected.…”

Section: Effect Of Ionic Liquids On Microorganismsmentioning

confidence: 99%

Ionic Liquids—A Review of Their Toxicity to Living Organisms

Gonçalves

Paredes

Cristino

et al. 2021

IJMS

117

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Ionic liquids (ILs) were initially hailed as a green alternative to traditional solvents because of their almost non-existent vapor pressure as ecological replacement of most common volatile solvents in industrial processes for their damaging effects on the environment. It is common knowledge that they are not as green as desired, and more thought must be put into the biological consequences of their industrial use. Still, compared to the amount of research studying their physicochemical properties and potential applications in different areas, there is a scarcity of scientific papers regarding how these substances interact with different organisms. The intent of this review was to compile the information published in this area since 2015 to allow the reader to better understand how, for example, bacteria, plants, fish, etc., react to the presence of this family of liquids. In general, lipophilicity is one of the main drivers of toxicity and thus the type of cation. The anion tends to play a minor (but not negligible) role, but more research is needed since, owing to the very nature of ILs, except for the most common ones (imidazolium and ammonium-based), many of them are subject to only one or two articles.

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Section: Effect Of Ionic Liquids On Microorganismsmentioning

confidence: 99%

Ionic Liquids—A Review of Their Toxicity to Living Organisms

Gonçalves

Paredes

Cristino

et al. 2021

IJMS

117

View full text Add to dashboard Cite

show abstract

“…The model could predict the MIC and MBC in the standard error of 0.341 and 0.282 log units, respectively. Similarly, Yan et al [62] which He et al [30] applied, and presented QSAR models to predict MIC and MBC of ILs to C. albicans with the good-of-fitness (R 2 ) of 0.930 and 0.873, respectively. Among bacterial species, the luminescent bacterium V. fischeri was mostly used for toxicity tests of ILs because it is sensitive, simple, and fast.…”

Section: Qsar For the Response Of Bacteriamentioning

confidence: 99%