QS264. Factors That Predict Malignancy in HÜrthle Cell Neoplasms of the Thyroid

Preoperative serum thyroglobulin concentration as a predictive factor of malignancy in small follicular and Hürthle cell neoplasms of the thyroid gland

“…The following predictive factors of malignancy have been reported in the literature [ 5 , 13 , 14 , 17 – 41 ]: the patient’s age [ 18 , 19 , 24 , 25 , 30 – 33 ] and sex [ 5 , 26 ], the tumor size [ 5 , 18 , 20 – 22 , 24 – 26 , 31 – 36 , 42 ], a solitary nodule [ 24 , 26 , 27 ], tumor fixation [ 25 ], a lesion that feels hard on palpation [ 27 ], Tg concentration [ 13 , 14 , 18 ], ultrasound characteristics [ 17 , 27 – 29 , 41 ], cytologic characteristic [ 21 ], and gene expression diagnostic markers [ 37 – 40 ]. Ultrasound characteristics predictive of malignancy are: the presence of internal blood flow (as detected by Doppler ultrasonography), the presence of hypervascularity, a solid echo structure, a hypoechoic lesion, or microcalcifications [ 17 , 27 – 29 , 41 ].…”

Predictive factors of carcinoma in 279 patients with Hürthle cell neoplasm of the thyroid gland

“…In Hürthle cell neoplasm, many clinical predictive factors have been described: patient's age [11,[13][14][15], tumor size [2,11,[13][14][15][16][17][18], and hardness to palpation [19]. The patients with carcinoma were older in comparison with those with a benign disease as reported by Carcangiu et al [11], Lopez-Penabad et al [13], Taneri et al [14], and Zhanga et al [15]. Lopez-Penabad's group [13] found that the average age of the patients with carcinoma was 8.7 years older in comparison with those with benign disease.…”

“…Many authors claim that diameter of the tumor increase the risk of malignancy [2,11,[13][14][15][16][17][18]. Gundry et al reported that tumors greater than 2 cm had a high risk of malignancy [18].…”

Hurtle-cell carcinoma of thyroid gland: literature review and own data

“…Поширеність пухлин з КГ становить 3-10 % усіх вузлів ЩЗ [13][14][15]. У ЩЗ можуть розвиватися як Гюртле-клітинні аденоми (ГКА), так і Гюртле-клітинні карциноми (ГКК).…”