QRS Widening Rates and Genetic Polymorphisms of Matrix Metalloproteinases in a Cohort of Patients With Chronic Heart Failure

Olsen, Virgílio da Rocha; Rohde, Luís Eduardo Paim; Beck-da-Silva, Luís; Santos, Kátia Gonçalves dos; Biolo, Andréia; Clausell, Nadine Oliveira; Andrades, Michael Éverton

doi:10.1016/j.cjca.2013.11.014

Cited by 8 publications

(14 citation statements)

References 30 publications

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“…During this process, MMP-2 was a key factor in cell migration. MMP-2 has been observed to play a contributing role in vessel remodeling [19], and it as an important player in several cardiovascular diseases [15][16][17]. 15-HETE-induced MMP-2 expression and angiogenesis may be involved in tumor growth and metastasis, and in HDMVECs; this is via AP-1-mediated MMP-2 expression [18].…”

Section: Discussionmentioning

confidence: 99%

“…Matrix metalloproteinase-2 (MMP-2) is expressed ubiquitously in various cell types including cardiomyocytes, endothelial cells, fibroblasts, and vascular smooth muscle cells and plays a crucial role in angiogenesis regulation [12][13][14]. MMP-2 and -9 are important players in several cardiovascular diseases including atherosclerosis, ischemic heart disease, and heart failure [15][16][17]. 15(S)-HETE induces MMP-2 expression and activation in HDMVECs and mediates 15(S)-HETE-induced HDMVEC migration, tube formation, and matrigel plug angiogenesis [18].…”

Section: Introductionmentioning

confidence: 99%

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STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration

Zhang

Liu

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration

Zhang

Liu

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…We previously reported that the 2G allele of the MMP-1 –1607 1G/2G polymorphism was associated with better prognosis in patients with systolic HF [25]. We also showed that HF patients with the MMP-1 2G2G genotype and the 6A allele of the MMP-3 –1171 5A/6A polymorphism had increased QRS widening rate [26]. Despite the role of MMP-2 in LV remodeling and HF prognosis, the impact of MMP-2 polymorphisms on HF remains unexplored and inconclusive [20,22–24].…”

Section: Introductionmentioning

confidence: 95%

Matrix Metalloproteinase-2 Polymorphisms in Chronic Heart Failure: Relationship with Susceptibility and Long-Term Survival

et al. 2016

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Circulating levels of matrix metalloproteinase-2 (MMP-2) predict mortality and hospital admission in heart failure (HF) patients. However, the role of MMP-2 gene polymorphisms in the susceptibility and prognosis of HF remains elusive. In this study, 308 HF outpatients (216 Caucasian- and 92 African-Brazilians) and 333 healthy subjects (256 Caucasian- and 77 African-Brazilians) were genotyped for the -1575G>A (rs243866), -1059G>A (rs17859821), and -790G>T (rs243864) polymorphisms in the MMP-2 gene. Polymorphisms were analyzed individually and in combination (haplotype), and positive associations were adjusted for clinical covariates. Although allele frequencies were similar in HF patients and controls in both ethnic groups, homozygotes for the minor alleles were not found among African-Brazilian patients. After a median follow-up of 5.3 years, 124 patients (40.3%) died (54.8% of them for HF). In Caucasian-Brazilians, the TT genotype of the -790G>T polymorphism was associated with a decreased risk of HF-related death as compared with GT genotype (hazard ratio [HR] = 0.512, 95% confidence interval [CI] 0.285–0.920). However, this association was lost after adjusting for clinical covariates (HR = 0.703, 95% CI 0.365–1.353). Haplotype analysis revealed similar findings, as patients homozygous for the -1575G/-1059G/-790T haplotype had a lower rate of HF-related death than those with any other haplotype combination (12.9% versus 28.5%, respectively; P = 0.010). Again, this association did not remain after adjusting for clinical covariates (HR = 0.521, 95% CI 0.248–1.093). Our study does not exclude the possibility that polymorphisms in MMP-2 gene, particularly the -790G>T polymorphism, might be related to HF prognosis. However, due to the limitations of the study, our findings need to be confirmed in further larger studies.

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“…Matrix metalloproteinases (MMPs) are a group of proteins that are capable of selectively degrading ECM and regulate most of the ECM remodeling in CHF patients via cardiac remodeling and left ventricular dilatation [ 114 ]. All MMPs are negatively regulated by tissue inhibitors of metalloproteinase (TIMPs), and MMP/TIMP imbalance may result in heart disease [ 115 ].…”

Section: The Detrimental Role Of Cardiokines In Cvdmentioning

confidence: 99%

The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?

Zhu

Luo

et al. 2018

BioMed Research International

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Cardiovascular disease remains the leading cause of morbidity and mortality, imposing a major disease burden worldwide. Therefore, there is an urgent need to identify new therapeutic targets. Recently, the concept that the heart acts as a secretory organ has attracted increasing attention. Proteins secreted by the heart are called cardiokines, and they play a critical physiological role in maintaining heart homeostasis or responding to myocardial damage and thereby influence the development of heart diseases. Given the critical role of cardiokines in heart disease, they might represent a promising therapeutic target. This review will focus on several cardiokines and discuss their roles in the pathogenesis of heart diseases and as potential therapeutics.

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QRS Widening Rates and Genetic Polymorphisms of Matrix Metalloproteinases in a Cohort of Patients With Chronic Heart Failure

Cited by 8 publications

References 30 publications

STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration

STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration

Matrix Metalloproteinase-2 Polymorphisms in Chronic Heart Failure: Relationship with Susceptibility and Long-Term Survival

The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?

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