QR encoded smart oral dosage forms by inkjet printing

Edinger, Magnus; Bar‐Shalom, Daniel; Sandler, Niklas

doi:10.1016/j.ijpharm.2017.11.052

Cited by 101 publications

(83 citation statements)

References 31 publications

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“…Inkjet printing is a contactless process of droplet deposition onto an appropriate carrier substrate, classically a paper sheet or foil. In case of drug printing, oromucosal films are the most reported substrates in literature [41,[95][96][97][98]. They resemble the usual types of substrates and offer a higher surface for drug imprints compared to tablets.…”

Section: Pharmaceutical Inkjet Printingmentioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

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Section: Pharmaceutical Inkjet Printingmentioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

Self Cite

View full text Add to dashboard Cite

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“…Moreover, this digital printing technique with great versatility, adaptivity, and universality promises not only high potential for industries to import inkjet printing into existing production lines but also unprecedented opportunities for broader audiences to design and customize do‐it‐yourself (DIY) optoelectronics just in office or household. To date, various kinds of inkjet‐printed functional devices have been realized, such as LEDs, displays, transistors, sensors, solar cells, integrated smart systems, etc …”

mentioning

confidence: 99%

Inkjet‐Printed Random Lasers

Liao

Chang

et al. 2018

Adv Materials Technologies

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Printing technology has led to a multitude of revolutions in design, conception, fabrication, and application of optoelectronics nowadays especially for wearables and one‐off devices. Recent advances range from solar cells, batteries, sensors, LEDs, displays, biomedical widgets to smart tags. Inkjet‐printed random lasers (IPRLs), demonstrated here, fill in the crucial but missing piece of the puzzle in printed optoelectronics as well as progress in laser research. A broad emission spectrum of IPRL inks covering more than 75% gamut of CIE color space is successfully exploited and well adopted by commercial desktop inkjet printers. Furthermore, based on the digital, ink‐efficient, mask‐free patterning, and drop‐on‐demand printing technique, a series of long‐anticipated proofs‐of‐concept including on‐chip laser lighting modules, red‐yellow‐green‐blue pixel‐based laser displays, and ink‐crypto/laser‐coded security printing technique are also demonstrated.

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“…quick response) na opakowanie jednostkowe leku lub bezpośrednio na film, w którym zapisana jest informacja dotycząca m.in. [22,27]: -danych pacjenta (nazwisko, wiek, masa ciała), -nazwy oraz dawki leku, -drogi podania oraz częstotliwości dawkowania, -daty produkcji oraz okresu przydatności do użycia, -numeru serii, -zastosowanych substancji pomocniczych, -warunków przechowywania, -danych lekarza przepisującego lek.…”

Section: Wytwarzanie Filmów Odf W Aptekachunclassified

“…Za pionierskie należy uznać badania prowadzone przez Edingera i wsp. [27], którzy nadrukowali na filmy ODF roztwór haloperidolu w postaci kodu QR w dawce 1 mg oraz 2,5 mg. Filmy na bazie HPMC z dodatkiem mezoporowatej krzemionki koloidalnej sporządzono metodą wylewania z odparowaniem rozpuszczalnika. Do roztworu substancji leczniczej dodano barwnik, aby kod QR mógł być odczytany przez odpowiednią aplikację w telefonie.…”

Section: Wytwarzanie Filmów Odf W Aptekachunclassified

Orodispersible films (ODF) in individualized therapy

Łyszczarz¹,

Niwiński²,

Jachowicz³

2019

Farm Pol.

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Orodispersible films (ODF) in individualized therapy • One of the mains factors affecting the effectiveness and safety of the therapy is the development of an appropriate dosage form adapted to the age of the patients and ease to administer as well as a dosing devices that provide flexible dosing. This approach is in accordance with the idea of patientcentered treatment. Given advantages such as safety, easy swallowing and flexible dose adjustment, special attention is paid to oral dosage forms such as orally disintegrating tablets, minitablets and orodispersible films (ODF). The ODF films are indicated as a suitable dosage form for pediatric, geriatric and uncooperative patients due to their fast disintegration in the mouth without need for water to facilitate swallowing, adhesion to the oral cavity to prevent spitting out the medicine and the ability to adjust the dose of the drug for an individual patient. According to many studies, orodispersible films are well accepted by infants and preschool children, their caregivers (nurses) and parents. They have the form of a postage stamp sized strip of thin polymeric film applied on the tongue. The ODF films can be manufactured using various methods, i.e. casting method, hot melt extrusion, electrospinning or printing (inkjet, flexographic and 3D printing) on an industrial scale and potentially in hospital pharmacies. Extemporaneous preparation of the ODF films create more dose flexibility affecting patient's adherence to pharmacotherapy. Innovative solutions in this area concern also designed specifically devices for storage and dosing of ODF, as well as methods of labeling and identification of single doses, for example Quick Response (QR) codes. The paper presents a review of the literature from recent years regarding new technology in the terms of the ODF films preparation, including manufacturing methods and modification of the drug release, as well as the possibilities of their application in individualization of the therapy especially in pediatric and geriatric population.

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QR encoded smart oral dosage forms by inkjet printing

Cited by 101 publications

References 31 publications

Oromucosal films: from patient centricity to production by printing techniques

Oromucosal films: from patient centricity to production by printing techniques

Inkjet‐Printed Random Lasers

Orodispersible films (ODF) in individualized therapy

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