Sensor technology advancements have provided the platform to implement wireless body area networks, thanks to the nanosized sensor units capable of sensing, aggregating, and forwarding physiological information. The collected information is routed to the desired destination unit for data analysis and decision-making in remote healthcare. However, improving energy utilization remains a brain-teasing problem for the research community, especially considering imbalanced energy consumption and postural movements. Mobility contributes to disconnectivity issues, high energy drainage, and delays due to retransmissions. In addition, the sensor node’s thermal level also poses a challenge in maintaining safer and reliable data transmission. To overcome these issues, a novel Mobility and Temperature Sensitive Energy-Efficient Routing ¬(MTS-EER) algorithm has been proposed that includes a two-step process. In step 1, an Intelligent Path Estimation Function (IPEF) is designed considering the mobility, temperature, and energy level of the sensor. IPEF depends on crucial parameters i.e.: - residual energy, signal-to-noise ratio (SNR), distance, total energy, and most importantly temperature of the sensor unit. The sensor node with the higher IPEF is selected as the Cluster Head (CH). In step 2, an optimized and sustainable energy conservation model (OSECM) is implemented based on the Adaptive Transmission Power (ATP) and the Power Management Module (PMM). The ATP conserves the energy via intelligently varying the transmission power and then PMM manages the sleep pattern of sensor nodes to yield a high network lifetime and efficient energy utilization. The algorithm further includes a clustering approach with dual sink nodes to conserve energy and improve reliability. Finally, the results are compared with the recent state-of-the-art research work. The proposed algorithm provides better results in terms of residual energy, throughput, network lifetime, and end-to-end delay.