Qol-34. A Four-Year Follow-Up Study of Neurocognition in Children Treated for a Brain Tumor

Lemiere, Jurgen; Vandereydt, Josefien; Wyngaert, Linde Van den; Vercruysse, Trui; Sleurs, Charlotte; Jacobs, Sandra

doi:10.1093/neuonc/noy059.616

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“…During the last few years, evidence for potential treatment‐induced neurotoxicity in pediatric oncology is increasing. So far, most evidence exists for brain tumor and ALL patients . However, these neurotoxic effects are mostly induced by radiotherapy (RT) .…”

Section: Introductionmentioning

confidence: 99%

Intellectual development of childhood ALL patients: a multicenter longitudinal study

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Intellectual development of childhood ALL patients: a multicenter longitudinal study

et al. 2016

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“…Нейротоксические эффекты могут быть острыми, подострыми или отдаленными по времени возникновения, обратимыми или необратимыми (или же частично обратимыми) по типу их регресса. При лечении опухолей центральной нервной системы нейротоксичность усугубляется действием самой опухоли на нервную систему, дополнительными методами терапии и собственно нейротоксичностью препарата [1,2]. Для детского возраста характерно развитие комплекса когнитивных нарушений на фоне химиотерапии [3][4][5].…”

Section: нейротоксические осложнения химиотерапии: изучение причин и unclassified

Neurotoxic Complications of Chemotherapy in Children. Literature Review

et al. 2020

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The article provides the review of literature on the issue of neurotoxic complications of chemotherapy in children. The data search was carried out in the PubMed, CyberLeninka, RSCI databases and others. There are many works devoted to studying the distribution, structure, and clinical features of chemo-induced neurological disorders in modern literature. In general, analysis of literature has shown that the incidence of neurotoxic complications varies widely depending on the research methods and used chemo-therapeutic drugs. Manifestations of chemotherapy-induced neurological disorders are quite diverse and accompanied by the central and peripheral nervous system damage. However, it has been shown that the platinum-based drugs have effective ototoxic effect with the damage of the auditory nerve. The Vincristine often causes peripheral polyneuropathy. Methotrexate and Ifosfamide cause metabolic encephalopathy. Cytarabine's neurotoxicity is the damage of the cerebellum. The addition of neurological symptoms leads to decrease in the quality of life of patients. Some studies present the results of study of the causes and pathogenetic manifestations of neurotoxic reactions, changes in the genome associated with the development of specific toxic effects are identified. Despite the fact that many pathogenetic mechanisms of chemotherapy-induced neurotoxic complications have been revealed, the significance of laboratory predictors for prognosing and early assessment of these complications has not been essentially established yet, thus, there is the need for further study of this topic.

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Qol-34. A Four-Year Follow-Up Study of Neurocognition in Children Treated for a Brain Tumor

Cited by 2 publications

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Intellectual development of childhood ALL patients: a multicenter longitudinal study

Intellectual development of childhood ALL patients: a multicenter longitudinal study

Neurotoxic Complications of Chemotherapy in Children. Literature Review

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