QM/MM Study of the Catalytic Mechanism and Substrate Specificity of the Aromatic Substrate C-Methyltransferase Fur6
Fan Zhao,
Yoshitaka Moriwaki,
Tomohiro Noguchi
et al.
Abstract:In the field of medical chemistry and other organic chemistry, introducing a methyl group into a designed position has been difficult to achieve. However, owing to the vigorous developments in the field of enzymology, methyltransferases are considered potential tools for addressing this problem. Within the methyltransferase family, Fur6 catalyzes the methylation of C3 of 1,2,4,5,7-pentahydroxynaphthalene (PHN) using Sadenosyl-L-methionine (SAM) as the methyl donor. Here, we report the catalytic mechanism and s… Show more
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