Qingre Yiqi Method along with Oral Hypoglycemic Drugs in Treating Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Abstract

Objective. To evaluate the efficacy of the Qingre Yiqi method in the treatment of type 2 diabetes mellitus (T2DM) with meta-analysis. Method. The randomized controlled trials (RCTs) of the Qingre Yiqi method in the treatment of T2DM in the PubMed, Medline, EMBase, Cochrane Library, Web of Science, Weipu Journal, China Knowledge Network (CNKI), and Wanfang database were conducted. Three reviewers independently conducted the screening, extracted the data, and assessed methodological quality. Data analysis was performed using Rev Man 5.3 software for statistical analysis. Results. A total of 15 RCTs, including 1440 patients, were included. The results showed that compared with oral hypoglycemic drugs alone, the add-on treatment of the Qingre Yiqi method could significantly improve Chinese medicine syndrome (OR (95%CI) = 3.66 [2.47,5.42], P < 0.00001 ) and lower the level of HbA1c (MD (95%CI) = −0.68 [0.91, −0.45], P < 0.00001 ), triglyceride (TG) (MD (95%CI) = −0.38 [−0.58,-0.17], P = 0.0004 ), low-density lipoprotein cholesterol (LDL-C) (MD (95%CI) = −0.25 [−0.37, −0.13], P < 0.0001 ), and total cholesterol(TC) (MD(95%CI) = −0.40[−0.67, −0.13], P = 0.003 ). In terms of fasting blood glucose (FBG) and postprandial blood sugar (PBG), subgroup analysis showed that the baseline of FBG and the number of combined oral hypoglycemic drugs of PBG were the major sources of heterogeneity. Conclusion. Compared with the standard treatment, the Qingre Yiqi method along with oral hypoglycemic drugs showed the more beneficial effects for T2DM on improving TCM syndromes and reducing the blood glucose and partial lipid parameter.

Treatment options of traditional Chinese patent medicines for dyslipidemia in patients with prediabetes: A systematic review and network meta-analysis

“…Although none of the results were statistically different, the baseline values of LDL-C were the most likely source of heterogeneity, which was also consistent with the meta-regression of previous NMA ( Zheng et al, 2020 ). The results of the subgroup analysis showed that the greater the baseline value, the more potent the lipid-lowering effect of TCPM if LDL-C did not reach the ideal value, which was consistent with previous results regarding the hypoglycaemic effect of TCPM ( Jiang et al, 2021 ). Notably, among the 4 studies that reported pathologically elevated LDL-C levels, two studies using Shenqi (Tian WJ, Yan J) and one using jinlida (Wang SM).…”

Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map

“…Another review concluded [ 47 ] that hypoglycemic events were reported in the RCT studies, but there was no significant difference between the control group (6 cases) and the TCM treatment group (5 cases). Jiang Li [ 48 ] alluded that one RCT reported 6 cases of hyperthermia in the control group and 4 cases of vomiting in the TCM group, and another RCT reported one case of hypoglycemia in both groups. One literature reported the incidence of GI adverse reactions in the TCM group was 2.5% while that in the control group was 7.5% [ 48 ].…”

“…Jiang Li [ 48 ] alluded that one RCT reported 6 cases of hyperthermia in the control group and 4 cases of vomiting in the TCM group, and another RCT reported one case of hypoglycemia in both groups. One literature reported the incidence of GI adverse reactions in the TCM group was 2.5% while that in the control group was 7.5% [ 48 ]. It has been indicated [ 53 ] that the combination of Liu Wei Di Huang Wan (soup) with metformin for T2DM has the potential to reduce the adverse effects of metformin.…”

Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double-Blind, Placebo-Controlled, Randomized Trial in Healthy Subjects

“…Complementary and alternative medicine (CAM) is usually defned as various health care and medical practices independent of western medicine [21]. Currently, CAM, such as the Qingre Yiqi method with oral hypoglycemic drugs and pomegranate seed powder, has been utilized in type 2 diabetes mellitus, which is one of the chronic diseases [22,23]. Furthermore, the previous study demonstrated that alkaloid berberine has been more efective in treating positive and negative symptoms of schizophrenia [24].…”