Qingre Huoxue Decoction regulates macrophage polarisation to attenuate atherosclerosis through the inhibition of NF-κB signalling-mediated inflammation

Jin, Zheng; Luo, Yuan; Zhao, Huanyi; Cui, Jiayan; Wang, He; Li, Junlong; Pi, Jianbin; Qing, Lijin; Wu, Wei

doi:10.1016/j.jep.2022.115787

Cited by 3 publications

(1 citation statement)

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“…In this landscape, Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, has shown promise in alleviating psoriasis in previous studies 6 . Comprising Sophora japonica (Huaihua) , 9 Angelica sinensis (Danggui) , 10 Sparganium stoloniferum (Sanleng) , 11 Curcuma zedoaria (Ezhu) , 12 and Spatholobus suberectus Dunn (Jixu eteng) , 13 QHD contains pharmacologically active ingredients like Rytub , ferulic acid , isocurcumenol , hexadecanoic acid , and formononetin 14 . This study aims to explore QHD's effects on wound healing within the psoriatic context, a significant yet under‐researched area due to the complex interplay between angiogenesis, inflammation, and tissue repair in psoriatic lesions.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine Qingre Huoxue decoction enhances wound healing in through modulation of angiogenic and inflammatory pathways

Li,

Chen,

Cai

et al. 2024

International Wound Journal

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This study investigates the therapeutic potential of Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, in promoting wound healing in an imiquimod‐induced murine model of psoriasis. The research was driven by the need for effective wound healing strategies in psoriatic conditions, where conventional treatments often fall short. Employing a combination of in vivo and in vitro methodologies, we assessed the effects of QHD on key factors associated with wound healing. Our results showed that QHD treatment significantly reduced the expression of angiogenic proteins HIF‐1α, FLT‐1, and VEGF, and mitigated inflammatory responses, as evidenced by the decreased levels of pro‐inflammatory cytokines and increased expression of IL‐10. Furthermore, QHD enhanced the expression of genes essential for wound repair. In vitro assays with HUVECs corroborated the anti‐angiogenic effects of QHD. Conclusively, the study highlights QHD's efficacy in enhancing wound healing in psoriatic conditions by modulating angiogenic and inflammatory pathways, presenting a novel therapeutic avenue in psoriasis wound management.

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