Abstract:Background: The patient/caregiver experience during CAR-T therapy is stressful, overwhelming, terrifying, and often a patient’s last treatment option. The Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Innovation and Design team has worked with the CAR-T therapy clinical team to develop a patient experience that provides patients with a sense of caring, supportive environment, timely knowledge, and realistic expectations. Using a human-centered design approach, the In… Show more
“…Little is known about patient priorities and needs after CAR-T therapy, but the current literature underscores the importance of appropriate information. By interviewing patients, Matthews et al found that most felt unprepared for the emotional aspects of CAR-T therapy nor were they prepared for the intensity of the toxicities (Matthews et al 2019). The importance of addressing issues, such as clear information on the treatment trajectory (Bamigbola et al 2021), financial toxicity, and the importance of family members and other caregivers, has also been described .…”
adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
“…Little is known about patient priorities and needs after CAR-T therapy, but the current literature underscores the importance of appropriate information. By interviewing patients, Matthews et al found that most felt unprepared for the emotional aspects of CAR-T therapy nor were they prepared for the intensity of the toxicities (Matthews et al 2019). The importance of addressing issues, such as clear information on the treatment trajectory (Bamigbola et al 2021), financial toxicity, and the importance of family members and other caregivers, has also been described .…”
adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
“…Centers have implemented a multidisciplinary evaluation from geriatricians, physical and occupational therapy, social workers, and dieticians before stem cell transplants to not only select appropriate patients but act on modifiable risk factors [54]. Other centers have implemented remote monitoring, utilizing the digital platform for patient education to identify barriers to access and study patient-reported outcomes [55]. For improved access, it is critical for a holistic approach for patients undergoing CAR T cell therapy.…”
Purpose of Review The chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR Tcell therapy is complicated, labor-intensive, and expensive. Recent Findings The chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive. Summary This review article addresses the present-day challenges and discusses opportunities to optimize the access and affordability of the CAR T-cell therapy. The field of cellular immunotherapy is going to change the future of solid tumors and non-oncological diseases. However, this promising therapy poses challenges in the administration and management of quality in the current field of healthcare. We describe various novel approaches to manage challenges in improving access and improving widescale implementation of cellular therapies.
“…Little is known about patient priorities and needs after CAR-T therapy, but the current literature underscores the importance of appropriate information. By interviewing patients, Matthews et al found that most felt unprepared for the emotional aspects of CAR-T therapy nor were they prepared for the intensity of the toxicities (Matthews et al 2019). The importance of addressing issues, such as clear information on the treatment trajectory (Bamigbola et al 2021), financial toxicity, and the importance of family members and other caregivers, has also been described (Foster et al 2020).…”
Understanding of what it means for patients to receive CAR-T therapy remains insufficient due to the small number of studies with a quality of life (QOL) focus, selection bias of respondents, high risk of attrition due to disease relapse, and limited length of follow-up. CAR-T therapy is often presented as a last option for patients with advanced disease. The primary aim of the treatment is patient survival and hopefully disease elimination. However, understanding other aspects of health, such as functional status, cognitive function, psychosocial concerns, and other health-related (QOL) issues, is key to appreciating the full impact of such therapies at both the individual and societal levels.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.