Qigong exercise enhances cognitive functions in the elderly via an interleukin-6-hippocampus pathway: A randomized active-controlled trial

Qi, Di; Wong, Nichol M.L.; Shao, Robin; Man, Idy S.C.; Wong, Clive H.Y.; Yuen, Lai Ping; Chan, Chi Chiu; Lee, Tatia M.C.

doi:10.1016/j.bbi.2021.04.011

Cited by 33 publications

(23 citation statements)

References 71 publications

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“…This finding might benefit from the fact that psychosomatic therapy has the dual mechanism of exercise and meditation that can relieve KOA pain and mood disorders (29,30). The underlying mechanism that physical exercise, combined with continuous cognitive challenge training, can maintain a new neuron pool experiences, more complex cognitive tasks, and even recruits new neurons to improve brain function (31). A functional magnetic resonance study has shown that the functional connectivity of dorsolateral prefrontal cortex with left hippocampus and amygdala was enhanced in Qigong group.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial

Zhang

Guo

et al. 2022

Front. Med.

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Background: Although traditional Chinese Yijinjing Qigong Exercise (YJJQE) is popularly used in China, to alleviate symptoms of people with knee osteoarthritis (KOA), no randomized controlled trials (RCTs) are available to evaluate the effects of YJJQE in patients with KOA. The purpose of this trial is to assess the clinical efficacy of YJJQE for patients with KOA.Methods: A total of 50 participants clinically diagnosed with KOA are randomly (1:1) assigned to the YJJQE group (n = 25) and to the stretching training exercise (STE) group (n = 25), for a 40-min exercise session twice a week for 12 weeks. All outcome measures are collected at baseline and at 12-week ending intervention, which includes the primary outcomes of Western Ontario and McMaster Universities Osteoarthritis Index Scale (WOMAC), the secondary outcomes of visual analog scale (VAS), mental component summary (MCS), physical component summary (PCS), Beck depression inventory (BDI), perceived stress scale (PSS), Berg balance scale (BBS), and the Gait functional mobility data.Results: The YJJQE group did not have any significant changes compared to the control group on the WOMAC score after the 12-week intervention (P > 0.05), though the YJJQE group demonstrated better performance in MCS, BDI, and PSS (P = 0.002, P = 0.001, and P = 0.026, respectively) than the control group. No serious adverse events occurred in either group, and only mild muscle soreness was reported during both exercise treatments.Conclusion: Because no difference between both groups was shown, with regards to the primary outcome measurement (WOMAC), it can hardly explain that the YJJQE had an advantageous effect on patients experiencing the pain and dysfunction of knee osteoarthritis. However, compared to the control group, YJJQE appeared to be associated with improvements in psychological well-being including reduced stress, anxiety, depression, and mood disturbance to manage KOA. Further trials with larger sample sizes and follow-up studies will be required.Clinical Trial Registration:https://www.chictr.org.cn/edit.aspx?pid=60357&htm=4, ChiCTR2000037256.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial

Zhang

Guo

et al. 2022

Front. Med.

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“…Evidence based on the medical Qigong and Tai-chi also shows that cognitive function improvement is related to the Chi-Kung practice, including hand-shaking moments 73 , 74 . PA with low intensity and resistance yielded less health-promoting effects; most elderly individuals were engaged in a more specific PA in parks or schools near their homes, and the intensity of PA was insufficient 75 , 76 . Nutrient supplements with fruits and vegetables are needed to reduce the risk of cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

The combined effect of physical activity and fruit and vegetable intake on decreasing cognitive decline in older Taiwanese adults

Wang

Huang

et al. 2022

Sci Rep

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The factors associated with cognitive decline among older adults include physical activity and fruit and vegetable intake. However, the long-term effects of concomitant physical activity and fruit and vegetable intake are unknown. This 16-year longitudinal study explored the joint effect of mitigating cognitive decline in a cohort of older Taiwanese individuals. Five population-based surveys (Taiwan Longitudinal Survey on Aging [1999–2015]) involving 4440 respondents over 53 years old in 1999 were conducted. Cognitive function was assessed using the Short Portable Mental Status Questionnaire (SPMSQ). The demographic, socioeconomic, health-related, behavioral, and disease status covariates were adjusted in the regression analysis. Trends in cognitive decline were observed over 16 years. The risk of cognitive decline decreased by 63% when high physical activity and high fruit and vegetable intake were combined (odds ratio 0.37; 95% confidence interval 0.23–0.59), indicating a potential combined effect of physical activity and fruit and vegetable intake on mitigating cognitive decline. These personal actions are safe, effective, and economical approaches to health promotion and disease prevention.

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“…Mechanistically, IL-6 levels influence neurocognitive functions by exacerbating neuroinflammation, controlling adult neurogenesis, and provoking the deposition of amyloid beta. For instance, a randomized controlled trial included qigong intervention to promote cognitive functions in older people [ 42 ]. The results revealed that the decrease in peripheral IL-6 and its modulating effect on hippocampus volume changes explain the qigong exercise’s positive effect on processing speed.…”

Section: Key Molecules Bridging Inflammation and Cognitionmentioning

confidence: 99%

Relationships between Inflammation and Age-Related Neurocognitive Changes

Jin

Chan

et al. 2022

IJMS

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The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this review, we discuss the potential mechanisms, including the development of vascular inflammation, neuroinflammation, organelle dysfunctions, abnormal cholesterol metabolism, and glymphatic dysfunctions as well as the role that the key molecules play in the immune-cognition interplay. We propose potential therapeutic pharmacological and behavioral strategies for ameliorating age-related neurocognitive changes associated with inflammation. Further research to decipher the multidimensional roles of chronic inflammation in normal and pathological aging processes will help unfold the pathophysiological mechanisms underpinning neurocognitive disorders. The insight gained will lay the path for developing cost-effective preventative measures and the buffering or delaying of age-related neurocognitive decline.

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Qigong exercise enhances cognitive functions in the elderly via an interleukin-6-hippocampus pathway: A randomized active-controlled trial

Cited by 33 publications

References 71 publications

The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial

The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial

The combined effect of physical activity and fruit and vegetable intake on decreasing cognitive decline in older Taiwanese adults

Relationships between Inflammation and Age-Related Neurocognitive Changes

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