Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway

Xiong, Meng; Ou, Chen; Yu, Chang; Qiu, Jingyue; Lu, Jing; Fu, Chaojun; Peng, Qinghua; Zeng, Meiyan; Song, Houpan

doi:10.1016/j.heliyon.2023.e22443

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…Yang et al reported that galangin (Gal), derived from Alpinia officinarum hance and propolis, alleviated myocardial ischemic reperfusion-induced ferroptosis by upregulating the mRNA and protein levels of antioxidant and phase II detoxifying enzymes, especially Nrf2 and GPx4 . Additionally, Xiong et al demonstrated that Qi-Shen-Tang (QST), containing a 1:1 composition of Lycium barbarum and Salvia miltiorrhiza , inhibited ferroptosis by targeting the Nrf2/GPx4 signaling pathway, thereby reducing retinitis pigmentosa-induced damage to retinal tissue . Furthermore, baicalin promotes Fe 2+ accumulation, ROS formation, MDA production, and inhibition of GSH/GSSG ratio by inhibiting the expression of Nrf2 downstream targets GPx4 and xCT, stimulating the occurrence of ferroptosis thereby inhibiting the growth of tumor cells .…”

Section: Antioxidant Effects Of Fpps On Lpmentioning

confidence: 99%

“…139 Additionally, Xiong et al demonstrated that Qi-Shen-Tang (QST), containing a 1:1 composition of Lycium barbarum and Salvia miltiorrhiza, inhibited ferroptosis by targeting the Nrf2/GPx4 signaling pathway, thereby reducing retinitis pigmentosa-induced damage to retinal tissue. 140 Furthermore, baicalin promotes Fe 2+ accumulation, ROS formation, MDA production, and inhibition of GSH/GSSG ratio by inhibiting the expression of Nrf2 downstream targets GPx4 and xCT, stimulating the occurrence of ferroptosis thereby inhibiting the growth of tumor cells. 141 These results were consistent with other studies reporting that kaempferol, 142 Gastrodin, 143 Olive oil (containing oleic acid and polyphenols), 144 and wogonin 145 activate the Nrf2/GPx4 pathway to mediate antioxidant activity.…”

Section: Antioxidant Effects Of Fpps On Lpmentioning

confidence: 99%

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Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence suggests that the phenolic hydroxyl groups in food-borne plant polyphenols (FPPs) make them effective antioxidants capable of preventing diseases triggered by cell membrane LP. Proper dietary intake of FPPs can attenuate cellular oxidative stress, especially damage to cell membrane phospholipids, by activating the Nrf2/GPx4 pathway. Nuclear factor E2-related factor 2 (Nrf2) is an oxidative stress antagonist. The signaling pathway regulated by Nrf2 is a defense transduction pathway of the organism against external stimuli such as reactive oxygen species and exogenous chemicals. Glutathione peroxidase 4 (GPx4), under the regulation of Nrf2, is the only enzyme that reduces cell membrane lipid peroxides with specificity, thus playing a pivotal role in regulating cellular ferroptosis and counteracting oxidative stress. This study explored the Nrf2/GPx4 pathway mechanism, antioxidant activity of FPPs, and mechanism of LP. It also highlighted the bioprotective properties of FPPs against LP and its associated mechanisms, including (i) activation of the Nrf2/GPx4 pathway, with GPx4 potentially serving as a central target protein, (ii) regulation of antioxidant enzyme activities, leading to a reduction in the production of ROS and other peroxides, and (iii) antioxidant effects on LP and downstream phospholipid structure. In conclusion, FPPs play a crucial role as natural antioxidants in preventing LP. However, further in-depth analysis of FPPs coregulation of multiple signaling pathways is required, and the combined effects of these mechanisms need further evaluation in experimental models. Human trials could provide valuable insights into new directions for research and application.

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Section: Antioxidant Effects Of Fpps On Lpmentioning

confidence: 99%

Section: Antioxidant Effects Of Fpps On Lpmentioning

confidence: 99%

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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“…GPX4 plays a crucial role in protecting retinal cells from oxidative stress and ferroptosis damage. It catalyzes the reduction of lipid peroxides by GSH, thereby protecting the cell membrane from oxidative damage, which is essential for maintaining retinal health ( 33 ). In ophthalmic diseases such as diabetic retinopathy, the downregulation of GPX4 may lead to increased oxidative stress, subsequently affecting the function and survival of retinal photoreceptor cells ( 34 ).…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Ferroptosis as a potential therapeutic target for age-related macular degeneration

Liu,

Liao

et al. 2024

Drug Discovery Today

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Qi-Shen-Tang alleviates retinitis pigmentosa by inhibiting ferroptotic features via the NRF2/GPX4 signaling pathway

Cited by 4 publications

References 57 publications

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Ferroptosis as a potential therapeutic target for age-related macular degeneration

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