Q fever endocarditis in Queensland.

Wilson, H G; Neilson, Graeme; Galea, E. G.; Stafford, Greg; O'Brien, M F

doi:10.1161/01.cir.53.4.680

Cited by 103 publications

(58 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yeaman et al (41) showed that Nine Mile, Priscilla (considered a reference strain for chronic Q fever [25] Various regimens were proposed in our study. Tetracycline has been the mainstay of treatment of Q fever endocarditis (5,33,36). Prescribed alone, it seems to improve the medical condition of patients as long as it is given (36).…”

Section: Resultsmentioning

confidence: 99%

“…Tetracycline has been the mainstay of treatment of Q fever endocarditis (5,33,36). Prescribed alone, it seems to improve the medical condition of patients as long as it is given (36). However, recovery of viable C. burnetii from valve tissue has been reported after 4 years of therapy with doxycycline (33).…”

Section: Resultsmentioning

confidence: 99%

“…The ideal duration of treatment is difficult to define since no criteria for a cure have been proposed at this time. The optimal duration remains undetermined, with suggestions ranging from 1 year of administration (36) to indefinite administration (31). In our study, serological testing was carried out once a month during the first six months and every 3 months thereafter.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis

Lévy¹,

Drancourt²,

Etienne³

et al. 1991

Antimicrob Agents Chemother

112

View full text Add to dashboard Cite

We studied 32 cases of Q fever endocarditis diagnosed in France between January 1985 and December 1989 to evaluate the efficacies of the different regimens of antibiotics used for treatment. Each patient was monitored during the treatment (range, 12 to 60 months), and clinical and biological information was computerized. Various treatments were prescribed, including doxycycline alone (9 cases) or in association with rifampin (4 cases), quinolones (16 cases), or sulfamethoxazole-trimethoprim (1 case). Two patients died before the beginning of the treatment. Nineteen patients had hemodynamic failure and subsequently underwent valve replacement. Nine valve tissue cultures were positive despite previous antibiotic treatment. In terms of their effects on mortality, the difference between doxycycline alone and doxycycline plus quinolones is statistically significant. We conclude that the addition of quinolones to doxycycline is beneficial. On the basis of clinical, serological, and valve tissue culture results, no treatment was able to cure Q fever endocarditis within 2 years, even with a combination of antibiotics. We advise a minimum duration of treatment of 3 years with therapy combining quinolones and doxycycline.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis

Lévy¹,

Drancourt²,

Etienne³

et al. 1991

Antimicrob Agents Chemother

112

View full text Add to dashboard Cite

show abstract

“…Patients with valvular prostheses are at the greatest risk (19). The median time to development of chronic Q fever was six months following acute infection, although a latent period of up to 20 years has been reported (20). Men account for the majority of cases (75% in one review [5]), no doubt due to the influence of occupational exposure.…”

Section: Discussionmentioning

confidence: 99%

Q fever endocarditis: A case report and review of the literature

Deyell

Chiu²,

Ross

et al. 2006

Canadian Journal of Cardiology

View full text Add to dashboard Cite

E ndocarditis is the most common presentation of chronic Q fever, a zoonosis caused by the obligate intracellular bacteria Coxiella burnetii. Commonly believed to be a rare disorder, it has been estimated to account for up to 5% of all endocarditis cases worldwide (1-3). It occurs almost exclusively in patients who have pre-existing valvular disease or who are immunocompromised (4). Unlike typical cases of endocarditis, the clinical presentation of chronic Q fever is often nonspecific. Furthermore, specialized techniques are required for identification of the organism, and echocardiographic evidence of infection is frequently absent (5). Without prompt recognition and appropriate antimicrobial therapy, the course of Q fever endocarditis is severe and potentially fatal. The following case demonstrates many of the clinical features of chronic Q fever and highlights the difficulty of obtaining the diagnosis. CASE PRESENTATIONA 31-year-old Caucasian man presented to a walk-in clinic complaining of progressive, exertional shortness of breath. He had moved to Calgary, Alberta, from Nova Scotia, where he had worked on a dairy farm, two years prior. Due to pre-existing congenital valvular heart disease, he was referred to the Adult Congenital Cardiology Clinic at the University of Calgary (Calgary, Alberta). The patient could barely climb one flight of stairs without significant shortness of breath, and had developed orthopnea and paroxysmal nocturnal dyspnea. He described occasional palpitations, but denied any syncopal episodes, chest discomfort or peripheral edema. There were no symptoms suggestive of systemic infection.Of note, the patient had been diagnosed with congenital aortic stenosis at the age of eight months and underwent open aortic valvulotomy. The patient was found to have a trileaflet valve with significant fusion of the leaflets. Catheterization at the age of 10 years revealed a peak residual gradient of 25 mmHg across the aortic valve with mild aortic insufficiency. Echocardiograms at the ages of 18 and 22 years demonstrated peak gradients of 37 mmHg and 56 mmHg, respectively, moderate aortic insufficiency and preserved left ventricular function. The patient had no cardiology follow-up after the age of 22 years.Physical examination revealed a blood pressure of 110/50 mmHg, a heart rate of 82 beats/min and a normal The case of a 31-year-old man from Alberta diagnosed with Q fever endocarditis is presented. To the authors' knowledge, this is the first case of Q fever endocarditis diagnosed in the province of Alberta. The patient had undergone open valvulotomy for congenital aortic stenosis as an infant. He presented with congestive heart failure secondary to severe aortic regurgitation and underwent mechanical aortic valve replacement. Early failure of the mechanical prosthesis and numerous laboratory abnormalities prompted an investigation for endocarditis, which was initially negative. Markedly positive serology eventually established the diagnosis of chronic Q fever. The patient subsequently underwent...

show abstract

“…Most cases involve the aortic or mitral valve in patients with preexisting valvular disease or prosthetic valves (27,31,39,73,74,79), but occasionally cases involve previously normal valves (26). Infection is a very indolent process, since many of the cases described have occurred many years after apparent exposure to C. bumetii.…”

Section: Pathogenesismentioning

confidence: 99%

Q fever

Reimer

1993

Clin Microbiol Rev

View full text Add to dashboard Cite

Q fever is an acute febrile illness first described in 1935 and now seen in many parts of the world. Human infection follows exposure to animals, especially domestic livestock. Recent outbreaks in metropolitan areas have implicated cats as the carrier of disease to humans. The etiologic agent, Coxiella burnetti, belongs to the family Rickettsiaceae, although it has distinct genetic characteristics and modes of transmission. Most recent attention has been focused on a number of large outbreaks of Q fever associated with medical research involving pregnant sheep. Although most infections are self-limited, some patients require prolonged treatment. Recent vaccines have had encouraging success in the prevention of disease in individuals at high risk of exposure.

show abstract

Q fever endocarditis in Queensland.

Cited by 103 publications

References 8 publications

Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis

Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis

Q fever endocarditis: A case report and review of the literature

Q fever

Contact Info

Product

Resources

About