Q Fever Chronic Osteomyelitis in Two Children

Costa, Beatríz; Morais, Andreia; Santos, Ana Sofia; Tavares, Delfin; Seves, Graça; Gouveia, Catarina

doi:10.1097/inf.0000000000000861

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…However, they have been increasingly reported in the last decade. Osteomyelitis, often multifocal, seems to be more a frequent presentation in children, with a total of 11 cases reported in the literature (577)(578)(579)(580)(581)(582)(583). In adults, the clinical presentation is more variable.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…The most frequently reported persistent infection in children is osteomyelitis, which is frequently multifocal, with evidence of granulomatous bone lesions (577)(578)(579)(580)(581)(582)(583). Cases of endocarditis have been described mainly in children with congenital heart disease (187,310,615).…”

Section: Burnetii Infection In Special Populations: Pregnant Womenmentioning

confidence: 99%

“…These cases involved children 11 and 13 years old. Osteomyelitis is treated with variable combinations of the following antibiotics: co-trimoxazole, ciprofloxacin, rifampin, doxycycline, clarithromycin, and azithromycin (578,581,582). The most frequent duration of treatment found in the literature is 6 months, and surgical drainage of multifocal osteomyelitis is often needed for cure (578).…”

Section: Treatment and Follow-up Of Pregnant Women And Childrenmentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Section: Burnetii Infection In Special Populations: Pregnant Womenmentioning

confidence: 99%

Section: Treatment and Follow-up Of Pregnant Women And Childrenmentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…For DNA extraction, fresh or frozen samples are preferable, although paraffin-embedded tissues have also been used successfully for the identification of chronic Q fever patients (Costa et al 2015). DNA extraction protocols vary from column to magnetic particle-based methods.…”

Section: Real-time Pcrmentioning

confidence: 99%

European Network for Neglected Vectors and Vector-Borne Infections COST Action Guidelines: What Is This About and What Is This For?

Charrel

Lempereur

Mihalca

et al. 2017

Vector-Borne and Zoonotic Diseases

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“…For DNA extraction, fresh or frozen samples are preferable, although paraffinembedded tissues have also been used successfully for the identification of chronic Q fever patients (Costa et al 2015). DNA extraction protocols vary from column to magnetic particle-based methods.…”

Section: Realtime Pcrmentioning

confidence: 99%

Critical Aspects for Detection ofCoxiella burnetii

Mori

Mertens

Cutler

et al. 2017

Vector-Borne and Zoonotic Diseases

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Abstract:Coxiella burnetii is a global distributed zoonotic γ-proteobacterium with an obligatory intracellular lifestyle. It is the causative agent of Q fever in humans and of coxiellosis amongst ruminants, albeit the agent is also detected in ticks, birds and various other mammalian species. Requirements for intracellular multiplication together with the necessity for biosafety level 3 facilities restrict the cultivation of C. burnetii to specialized laboratories. Development of a novel media formulation enabling axenic growth of C. burnetii has facilitated fundamental genetic studies. This review provides critical insights into direct diagnostic methods currently available for C. burnetii. It encompasses molecular detection methods, isolation and propagation of the bacteria and its genetic characterization. Differentiation of C. burnetii from Coxiella-like organisms is an essential diagnostic prerequisite, particularly when handling and analyzing ticks.

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Q Fever Chronic Osteomyelitis in Two Children

Cited by 11 publications

References 10 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

European Network for Neglected Vectors and Vector-Borne Infections COST Action Guidelines: What Is This About and What Is This For?

Critical Aspects for Detection ofCoxiella burnetii

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