Q fever cases at a North Queensland centre during 1994–2006

Gale, Marianne; Ketheesan, Natkunam; Govan, Brenda; Kennedy, Richard L.; Norton, Robert

doi:10.1111/j.1445-5994.2007.01441.x

Cited by 20 publications

(19 citation statements)

References 18 publications

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“…However, present research and some other previous reports showed that there was no correlation between seropositive cases and direct contact with farm animals (Gale et al, 2007;Tozer et al, 2014). It was hypothesised that other risk factors (except farm animals contact) like wildlife contact, tick exposure or pet-owners who worked closely with other farm animals would have a positive association with seropositivity to C. burnetii in the pets (Cooper et al, 2011).…”

Section: Discussioncontrasting

confidence: 63%

Serological evidence of Coxiella burnetii infection among companion dogs in Fars Province, South Iran

Esmailnejad¹,

Hasiri²

2017

BJVM

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Coxiella burnetii is an important zoonosis at a global scale. The epidemiological role of dogs in transmission of Q fever has recently been demonstrated, but there is still a dearth of information on the subject. The aim of present study was to evaluate the occurrence and seroprevalence of Coxiella burnetii infection among companion dogs population in Fars province, South Iran. Blood samples were collected from 181 asymptomatic dogs, mostly referred to Veterinary Hospital of Shiraz University for regular vaccination. The IgG antibody detection against C. burnetii was made by indirect Enzyme-linked Immunosorbent Assay (ELISA), employing C. burnetii phase I and II antigens. A logistic regression model was developed to analyse multiple risk factors associated with seropositivity. Specific antibodies against C. burnetii were detected in 14 (7.7%) cases, 12 with S/P% of 20-50% and 2 with S/P% greater than 80%. Prevalence was significantly higher in adult dogs above 5 years (18.18 %; 2 out of 11) compared with dogs between 1 and 5 years (7.86 %; 7 out of 89) and less than 1 year (6.17%; 5 out of 81) (P=0.043). Prevalence was also higher in male dogs (11.21 %; 12 out of 107) than in female (2.7 %; 2 out of 74) (P=0.035). Breed, type of housing, type of food and exposure to other farm animals showed no significant differences between positive and negative cases (P>0.05). The results of this study showed the presence of C. burnetii infection among the companion dogs population in Iran, which could be a public health concern for humans. In areas like Iran, where human cases of Q fever are not common or remain unreported, the public health implications of Q fever seroprevalence in dogs are quite significant.

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Section: Discussioncontrasting

confidence: 63%

Serological evidence of Coxiella burnetii infection among companion dogs in Fars Province, South Iran

Esmailnejad¹,

Hasiri²

2017

BJVM

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“…11 In North Queensland, a study of Q fever cases during 1994-2006, found that 22% of acute and 33% of chronic Q fever patients reported exposure to cattle. 12 This trend extends internationally, where an occupation in the meat-processing industries has been associated with increased risk of Q fever infection. 1 Infections in animals are usually subclinical, although infection can be associated with abortions and reproductive disorders.…”

mentioning

confidence: 99%

“…In a recent series of cases over a 20‐year period in southern Australia, 92% of the 111 cases of Q fever were among abattoir workers 11 . In North Queensland, a study of Q fever cases during 1994–2006, found that 22% of acute and 33% of chronic Q fever patients reported exposure to cattle 12 . This trend extends internationally, where an occupation in the meat‐processing industries has been associated with increased risk of Q fever infection 1 …”

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confidence: 99%

Serological evidence of Coxiella burnetii infection in beef cattle in Queensland

Cooper

Hedlefs²,

McGowan

et al. 2011

Aust Veterinary J

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Background Queensland has the highest incidence of Q fever in Australia. The aim of this study was to undertake a cross‐sectional seroprevalence survey of Coxiella burnetii, the causative agent of Q fever, in beef cattle in Queensland. Methods Serum samples were tested by ELISA for both phase II and phase I antigens of the organism using an Australian isolate. Blood samples were collected at an abattoir that processes beef cattle originating from northern and north‐western Queensland, in addition to blood samples taken from beef cattle across Queensland as part of a second survey. Results Seropositivity was 16.8% (95% confidence interval 16.7–16.8%). Conclusion Evidence of C. burnetii infection in beef cattle has public health implications for occupational exposure of primary producers and veterinarians and for the proximity of beef cattle properties to residential areas in regional Queensland. This study is the first known investigation of C. burnetii seroprevalence in beef cattle in Queensland and the first known use of an Australian C. burnetii isolate for screening using both phase II and phase I antigens.

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“…Various patterns of bone marrow involvement have been described in Q fever, including granuloma formation, marrow necrosis and angiitis [22][23][24]. Although a low platelet count is a common finding in acute Q fever [25], profound thrombocytopaenia or unexplained pancytopaenia should prompt the consideration of haemophagocytosis in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen

2011

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We describe an unusual presentation of Q fever with associated haemophagocytic syndrome, confirmed by bone marrow aspirate, Q fever polymerase chain reaction (PCR) and serological testing. Clinical recovery was observed after the commencement of doxycycline with normalisation of the patient's full blood count and serum biochemistry. Serial monitoring of the Q fever serology revealed the subsequent development of sustained high phase 1 IgG antibodies, suggestive of chronic Q fever. Although many infectious aetiologies have been associated with haemophagocytosis, Q fever has only rarely been described in this context. The diagnosis of Q fever is often overlooked, especially when the presentation is atypical. We describe how the use of PCR testing significantly shortened the interval to definitive diagnosis and helped elucidate the underlying cause of the patient's haematological disorder.

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Q fever cases at a North Queensland centre during 1994–2006

Cited by 20 publications

References 18 publications

Serological evidence of Coxiella burnetii infection among companion dogs in Fars Province, South Iran

Serological evidence of Coxiella burnetii infection among companion dogs in Fars Province, South Iran

Serological evidence of Coxiella burnetii infection in beef cattle in Queensland

Coxiella burnetii causing haemophagocytic syndrome: a rare complication of an unusual pathogen

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