Q fever and spontaneous abortion

Quijada, S. González; Terán, B.M.; Murias, Patricia Siesto; Anitua, Ainhoa Aregita; Cermeño, J.L.B.; Frías, A.B.

doi:10.1111/j.1469-0691.2011.03562.x

Cited by 32 publications

(34 citation statements)

References 25 publications

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“…In a study conducted on 500 pregnant women, Quijada et al [8], found seropositivity as 32.2% in the 273 women with a history of spontaneous abortion, while in the control group it was found as 23.3% (p˂0.01). As a result of this study, it was concluded that active or the recent Q fever infection is associated with the risk of abortion.…”

Section: Discussionmentioning

confidence: 95%

A preliminary report of relationship between abortion and Q fever in Central Black Sea Region Turkish woman

Günal¹,

Demirtürk²,

Barut³

et al. 2014

Cumhuriyet Med J

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Aim. Q fever, which is a zoonosis caused by Coxiella burnetii, may result in abortions in infected animals and pregnant women. In our study, we searched the association between Q fever serology and abortion in a region where Q fever is endemic. Method. This study was conducted in Gaziosmanpaşa University Hospital between March and May 2012. A total of 100 women, from these, 64 had a history of spontaneus abortion (cases) and 36 had live births with no complicated obstetrics history or complicated partum (controls), enrolled in the study. Both groups were compared according to where they live, underlying diseases, contact with farm animals or pets and village connectivity. Results. IgG seroprevalence of Coxiella in our study group with the history of abortion was 15.6%, and 11.1% in the control group (p>0.05). When case and control groups were compared, the frequency of inhabitants of the village (p=0.012), subjects who had contact with farm animals [p=0.026, especially cattle (p=0.013)] or domestic animals (p=0.018) in case group were more common than the control group. When all the samples were analyzed, it was seen that the only significant variable affecting Coxiella IgG seropositivity was residency in rural area or visiting rural area (p=0.018). Conclusions. We have found that the relation between abortion and Q fever infection was not statistically significant. On this issue, multicenter studies which have the higher number of samples are needed in our country.Keywords: Q fever, spontaneous abortions, endemic region Özet Amaç. Q ateşi Coxiella burnetii tarafından oluşturulan bir zoonozdur. Q ateşi gebe hayvanlarda ve gebe kadınlarda abortusa neden olabilir. Biz bu çalışmamızda Q ateşi için endemik bir bölgede Q ateşi seropozitifliği ve abortus arasındaki ilişkiyi araştırdık. Yöntem. Bu çalışma Gaziosmanpaşa Üniversitesi Hastanesinde Mart 2012-Mayıs 2012 tarihleri arasında yürütüldü. Çalışmaya 18 yaş üzerinde toplam 100 kadın dahil edildi. Bunların 64'ünün spontan abortus hikayesi pozitif (vaka grubu) iken 36'sının hiç komplikasyonlu gebelik veya doğum hikayesi yoktu (kontrol grubu). Her iki grup yaşadıkları yer, altta yatan hastalıkları, çiflik hayvanı veya evcil hayvanlarla temas ve köy yaşantısı ile ilişki açısından karşılaştırıldı. Bulgular. Vaka grubunda Coxiella lgG seropozitifliği %15,6 çıkarken kontrol grubunda %11,1 olarak saptandı, bu fark istatistiksel olarak anlamlı değildi (p>0,05). Vaka grubu kontrol grubuyla karşılaştırıldığında köyde yaşama (p=0,012), çiftlik hayvanları ile temas [p=0,026; özellikle koyun (p=0,013)] veya evcil hayvanlarla temas (p=0,018) vaka grubunda anlamlı derecede daha yüksek saptandı. Tüm örnekler analiz edildiğinde Coxiella IgG seropozitifliğini etkileyen en önemli değişken kırsal alanda yaşama veya kırsal yaşamla ilişkili olma olarak bulundu (p=0,018). Sonuç. Çalışmanın sonucunda Q ateşi ile abortus arasında anlamlı bir ilişki bulunamadı. Bu çalışma bu konuyla ilgili ülkemizde yapılmış ilk çalışma olmakla birlikte çok merkezli ve yüksek örneklem sayılı çalışmal...

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Section: Discussionmentioning

confidence: 95%

A preliminary report of relationship between abortion and Q fever in Central Black Sea Region Turkish woman

Günal¹,

Demirtürk²,

Barut³

et al. 2014

Cumhuriyet Med J

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“…The First in the context of valvular endocarditis [13,14], and the other by infection of vascular atherosclerotic plaques. This second mechanism has not been tested, but this action is not only biologically plausible [16][17][18], but also probable [15]. Furthermore, the presence of this mechanism could explain some of our results; as independence showing this association with the presence of cardioembolic focus.…”

Section: Discusionmentioning

confidence: 87%

“…This addition to the group of potential pathogens involved in cerebrovascular disease is fully justified. If it is due to a germ of intracellular growth [16], it can persist in the body for long periods of time [14], reactivated in case of immunosuppression [16] or pregnancy [17], and promote inflammation, thrombosis and embolus in vascular beds [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Persistent Q fever and ischaemic stroke in elderly patients

González-Quijada

Salazar-Thieroldt

Mora-Simón

2015

Clinical Microbiology and Infection

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Whether persistent or chronic Q fever may act as a risk factor for stroke is unknown. A case-control study was conducted in the Hospital Universitario de Burgos (Spain) between February 2011 and December 2012. A total of 803 samples from 634 consecutive hospitalized patients ≥65 years old were tested, of whom 111 were cases (patients with prevalent or incident ischaemic stroke and/or transient ischaemic attack) and 523 were controls (patients without ischaemic stroke and/or transient ischaemic attack). Immunoglobulin G (IgG) antibody titres phase I and II against Q fever, and IgG antibodies levels against Chlamydia pneumoniae and cytomegalovirus (CMV), were determined using immunofluorescence assay and ELISA methods, respectively. Phase I IgG titres against Coxiella burnetii ≥1:256 (compatible with chronic or persistent Q fever) were detected in 16 of 110 (14.5%) cases and in 32 of 524 (6.1%) controls; P = .004, odds ratio (OR) 2.6, 95% confidence interval (CI) 1.3 to 4.9. This ratio was maintained after adjusting for age, sex, hypertension, dyslipidaemia, cardioembolic focus, smoking, diabetes, other cardiovascular diseases, C-reactive protein, and leukocyte count (OR 2.6, 95% CI 1.3 to 5.3). High-titre IgG antibodies (top quartile) against CMV (OR 2.1, 95% CI 1.3 to 3.5), but not against C. pneumoniae (OR 0.9, 95% CI 0.5 to 1.6), also were associated with ischaemic stroke after adjustment for risk factors. In conclusion, serology compatible with persistent or chronic Q fever is associated with ischaemic stroke in elderly patients. High levels of IgG antibodies against CMV, but not against C. pneumoniae, also are associated with ischaemic stroke in these patients.

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“…Q fever endocarditis can occur months to years after the primary infection, particularly in people with cardiovascular abnormalities (Raoult et al., ; Million and Raoult, ; Million et al., ). Additionally, QF can result in premature pregnancy termination or complications in pregnant women (Quijada et al., ; Million and Raoult, ).…”

Section: Introductionmentioning

confidence: 99%

The Epidemiology and Characteristics of Q fever and Co‐infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study

Lai

Sun²,

Lee

et al. 2016

Zoonoses and Public Health

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Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only a few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although QF is endemic in Taiwan, a nationwide database investigation of the epidemiology and characteristics of QF and its associations with scrub typhus (ST), murine typhus (MT) and leptospirosis (LS) has never been reported. We analysed nationwide databases of suspected QF, ST, MT and LS cases from October 2007 to December 2014 obtained from the Centers for Disease Control, Taiwan. A total of 468 (4.2%) QF cases were identified among 11 109 suspected QF cases. QF cases were mainly distributed in the southern and Kaohsiung-Pingtung regions but rarely in the eastern region. Compared to non-QF cases, QF cases had significantly higher percentages of males (88.7 versus 66.2%) and high-risk occupations (farming, animal husbandry or veterinary medicine) (16.2 versus 10.5%). But the percentages of specific animal contact, including cattle (0.6 versus 0.8%) and goats (0.9 versus 1.0%), were low in both. The majority of suspected QF cases (89.4%) were simultaneously suspected with ST, MT or LS, and the combinations of suspected diseases differed between regions. The number of suspected QF cases from the eastern region decreased since 2009, which was not observed in other regions. A total of 1420 (12.8%) cases had confirmed diseases, including QF (453, 4.1%), QF+ST (7, 0.06%), QF+MT (4, 0.04%), QF+LS (4, 0.04%), MT (186, 1.7%), ST (545, 4.9%), ST+LS (11, 0.1%) and LS (210, 1.9%). Compared to cases of unknown disease, QF cases had larger percentages of high-risk occupations (16.2 versus 9.6%) but similar histories of animal contact (29.8 versus 25.1%). QF is an endemic disease in southern Taiwan. It is difficult to differentiate QF from ST, MT or LS only by high-risk occupations and history of animal contact, and co-infection of QF with these diseases should be considered.

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Q fever and spontaneous abortion

Cited by 32 publications

References 25 publications

A preliminary report of relationship between abortion and Q fever in Central Black Sea Region Turkish woman

A preliminary report of relationship between abortion and Q fever in Central Black Sea Region Turkish woman

Persistent Q fever and ischaemic stroke in elderly patients

The Epidemiology and Characteristics of Q fever and Co‐infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study

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