Q fever: A rural disease with potential urban consequences

Eastwood, Keith; Graves, Stephen; Massey, Peter; Bosward, Katrina L.; Berg, Debra van den; Hutchinson, P. B.

doi:10.31128/afp-08-17-4299

Cited by 27 publications

(39 citation statements)

References 19 publications

(28 reference statements)

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“…The common acute symptoms of Q fever are asthenia, myalgia, fever, rigors, chills, cough, arthralgia, extreme fatigue, drenching sweats, weight loss and headache, in conjunction with abnormal liver function tests [1,3,5,6]. Deranged liver function due to hepatitis is a very common finding in Q fever, which we also observed in our case.…”

Section: Discussionsupporting

confidence: 77%

“…Acute Coxiella burnetii infection is typically mild and self limiting within two weeks. Even when present, the clinical manifestation of Q fever are nonspecific with no pathognomonic symptoms or signs, but with features seen in respiratory disease and hepatitis from other causes, thereby rendering the diagnosis a difficult one to convincingly arrive at clinically [1,5,6]. Our reported case demonstrated both respiratory and abdominal symptoms, but the abdominal pain predominated in the initial stage of his illness, resulting in an invasive investigative procedure indicated by the query of possible peritonitis.…”

Section: Discussionmentioning

confidence: 82%

“…Q fever is an endemic zoonotic infection in Australia cause by Coxiella burnetii. It has been recognised in other parts of the world, especially among livestock rearing occupations, stock yard and abattoir workers [1][2][3]. Coxiella burnetii can be harboured in most herd and domestic animals including cattle, goats, sheep and dogs, Macropods such as kangaroos and wombats, and also in ticks that are associated with some of these animals [2,3].…”

Section: Discussionmentioning

confidence: 99%

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An unusual presentation of a known condition: Q fever manifesting as an acute abdomen

2019

IJCR

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An unusual presentation of a known condition: Q fever manifesting as an acute abdomen Q fever is an endemic zoonotic infection in Australia cause by Coxiella burnetii. It has been recognised in other parts of the world, especially among livestock rearing occupations, stock yard and abattoir workers. Majority (65%) of patients infected with C.burnetti are asymptomatic while symptoms similar to those of respiratory and hepatitis are the most common making diagnosis difficult in the early stages.We report a case of a young man who was exposed to and infected with Q fever as an occupational hazard. He presented in an unusual way with the predominant initial symptoms of abdominal pain, fever, hepatitis and sterile peritonitis necessitating an emergency surgical procedure to explore a suspected surgical abdomen. Respiratory involvement ensued only several days later. The diagnosis of Q fever was confirmed with positive convalescent serology phase II IgM and IgG antibodies to Coxiella burnetii. A marked clinical response to doxycycline pending serological confirmation was supportive of this highly suspected diagnosis in an at-risk patient.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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An unusual presentation of a known condition: Q fever manifesting as an acute abdomen

2019

IJCR

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“…Q fever is a worldwide zoonosis caused by the obligate intracellular Gram-negative and highly infectious bacterium Coxiella burnetii. Humans are usually infected through the inhalation of aerosols contaminated by secretions of infected animals (1). In humans, Q fever either is subclinical or results in a variety of flu-like symptoms, including fever, headache, myalgia, and other respiratory complications (2,3).…”

mentioning

confidence: 99%

Comparison of Different Commercially Available Enzyme-Linked Immunosorbent Assays with Immunofluorescence Test for Detection of Phase II IgG and IgM Antibodies to Coxiella burnetii

Dangel¹,

Koempf²,

Fischer³

2020

J Clin Microbiol

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Several commercially available enzyme-linked immunosorbent assays (ELISAs) for the detection of phase II IgG or IgM antibodies against Coxiella burnetii were compared. In addition, an indirect immunofluorescence test was used as a confirmation test. In all, 70 serum samples for IgG and 43 serum samples for IgM were tested. The ELISAs showed large differences in sensitivity and specificity, which led to a partially high ratio of false-negative determinations. The most convincing test was PanBio from Abbott, which unfortunately can only test IgG but not IgM.

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“…İnsandan insana bulaş nadirdir, ancak enfekte anneden bebeğe, kemik iliği transplantasyonu ve transfüzyonla da bulaş olabilmektedir. Ayrıca enfekte sütün oral alımıyla da bulaş olabildiği bildirilmektedir (1)(2)(3)(4).…”

unclassified

Erzurum, Kars ve Ardahan İllerindeki Süt Ve Süt Ürünleri Üreticilerinde Q Ateşi Seroprevalansının Araştırılması

Aslan

Ayyıldız

2020

Kocatepe Tıp Dergisi

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ÖZ AMAÇ: Bu çalışmada Erzurum, Kars ve Ardahan illerinde süt ve süt ürünleri üreticilerinde Q Ateşi seroprevalansının araştırılması amaçlanmıştır. GEREÇ VE YÖNTEM: İllerin nüfus yoğunlukları ile bu illerde süt ve süt ürünleriyle uğraşanlardan belirlenen 18 yaş üzeri 153 kişiden alınan kan örneklerinden elde edilen serumlarda İFA yöntemiyle C.burnetii'ye karşı oluşan IgG ve IgM antikorları araştırılmıştır. BULGULAR: Total seropozitiflik oranı Erzurum'da %87.8, Kars'da %92, Ardahan'da %76.2 olarak saptanmıştır. Çalışmaya alınan 153 serumdan 110'unda (%71,9) Faz I antijenlerine karşı oluşan IgG, 24'ünde (%15.7) Faz II Antijenlerine karşı oluşan IgM antikoru saptanmıştır. 19 serumda ise (%12.4) sonuç negatif bulunmuştur. Total seropozitiflik oranı erkeklerde %88.7, kadınlarda %85.7 saptanmıştır. C.burnetii IgG erkeklerin %80.4, kadınların %57.1'inde, IgM ise erkeklerin %8.2 kadınların %28.6'sında pozitif saptanmıştır. Cinsiyete göre IgG ve IgM arasındaki fark istatistiksel olarak anlamlıyken, total seropozitiflikte anlamlı değildi. Yaş gruplarına göre total seropozitiflik oranı 18-29 yaş grubunda %58.3, 30-49 yaş grubunda %86.9, 50-69 yaş grubunda %88.7, 70 yaş üzerinde %100, C.burnetii IgG pozitiflik oranı 18-29 yaş grubunda %61.8, 30-49 yaş grubunda %76.8, 50-69 yaş grubunda %70.5, 70 yaş üzerinde %83.3 saptanmıştır. SONUÇ: Erzurum, Kars ve Ardahan illerinde Q Ateşinin seroprevalansı Türkiye'nin diğer bölgelerine göre yüksek bulunmuştur. Ülkemiz ekonomisini yakından ilgilendiren bu hastalığın kontrol altına alınması için gerekli önlemlerin alınması, hayvan yetiştiricilerinin eğitilmesi, süt ve süt ürünlerinin satışının denetlenmesi gerekmektedir. Kliniklerde sebebi bilinmeyen ateş tanısı ile takip edilen hastaların Q Ateşi yönünden de incelenmesi, hastalığın prevalansının ortaya konulması ve kontrol altına alınmasında yararlı olacaktır. ANAHTAR KELİMELER: Q Ateşi, İFA ABSTRACT OBJECTIVE: This study aimed to estimate Q Fever seroprevalence in milk and dairy product manufacturers in Erzurum, Kars, and Ardahan Provinces. MATERIAL AND METHODS:The IgG and IgM antibodies against C.burnetii were investigated using the IFA method in the serum obtained blood samples taken from 153 people over the age of 18 determined by the population density of the provinces and those dealing with milk and milk products in these provinces. RESULTS:Total seropositivity rate was 87.8 %, 92%, and 76.2% in Kars, Erzurum, and Ardahan, respectively. Of the 153 serum samples examined in the study; IgG antibodies against Phase I antigens were detected in 110 (71.9%) samples, and IgM antibodies against Phase I antigens were detected in 24 (15.7%) samples.The test results were negative in 19 (12.4%) samples. The rate of total seropositivity was 88.7% in males and 85.7% in females. C.burnetii IgG was detected in 80.4% of males and 57.1% of females. The IgM antibodies against C.burnetii were found in 8.2% of males and 28.6% of the females. The findings associated with IgG and IgM were statistically significantly different between the two genders; howe...

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Q fever: A rural disease with potential urban consequences

Cited by 27 publications

References 19 publications

An unusual presentation of a known condition: Q fever manifesting as an acute abdomen

An unusual presentation of a known condition: Q fever manifesting as an acute abdomen

Comparison of Different Commercially Available Enzyme-Linked Immunosorbent Assays with Immunofluorescence Test for Detection of Phase II IgG and IgM Antibodies to Coxiella burnetii

Erzurum, Kars ve Ardahan İllerindeki Süt Ve Süt Ürünleri Üreticilerinde Q Ateşi Seroprevalansının Araştırılması

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