Pyrroloquinoline–quinone synthesized in Escherichia coli by pyrroloquinoline–quinone synthase of Deinococcus radiodurans plays a role beyond mineral phosphate solubilization

Khairnar, Nivedita P.; Misra, Hari S.; Apte, Shree Kumar

doi:10.1016/j.bbrc.2003.10.121

Cited by 50 publications

(64 citation statements)

References 21 publications

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“…PQQ was found to prevent cognitive deficits caused by oxidative stress in rats (470) and to prevent oxidative injury in rat cardiomyocytes (606). Deinococcal PQQ safeguards E. coli against ROS, directly or via the stimulation or induction of the antioxidant enzymes catalase and superoxide dismutase (290), and is potentially valuable in antioxidant therapy. Lipoic acid and folates may also partake in the D. radiodurans arsenal of antioxidants (678).…”

Section: Some Ramifications Of D Radiodurans Oxidative Stress Resistmentioning

confidence: 99%

Oxidative Stress Resistance inDeinococcus radiodurans

Slade

Radman

2011

Microbiol Mol Biol Rev

648

639

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SUMMARY Deinococcus radiodurans is a robust bacterium best known for its capacity to repair massive DNA damage efficiently and accurately. It is extremely resistant to many DNA-damaging agents, including ionizing radiation and UV radiation (100 to 295 nm), desiccation, and mitomycin C, which induce oxidative damage not only to DNA but also to all cellular macromolecules via the production of reactive oxygen species. The extreme resilience of D. radiodurans to oxidative stress is imparted synergistically by an efficient protection of proteins against oxidative stress and an efficient DNA repair mechanism, enhanced by functional redundancies in both systems. D. radiodurans assets for the prevention of and recovery from oxidative stress are extensively reviewed here. Radiation- and desiccation-resistant bacteria such as D. radiodurans have substantially lower protein oxidation levels than do sensitive bacteria but have similar yields of DNA double-strand breaks. These findings challenge the concept of DNA as the primary target of radiation toxicity while advancing protein damage, and the protection of proteins against oxidative damage, as a new paradigm of radiation toxicity and survival. The protection of DNA repair and other proteins against oxidative damage is imparted by enzymatic and nonenzymatic antioxidant defense systems dominated by divalent manganese complexes. Given that oxidative stress caused by the accumulation of reactive oxygen species is associated with aging and cancer, a comprehensive outlook on D. radiodurans strategies of combating oxidative stress may open new avenues for antiaging and anticancer treatments. The study of the antioxidation protection in D. radiodurans is therefore of considerable potential interest for medicine and public health.

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Section: Some Ramifications Of D Radiodurans Oxidative Stress Resistmentioning

confidence: 99%

Oxidative Stress Resistance inDeinococcus radiodurans

Slade

Radman

2011

Microbiol Mol Biol Rev

648

639

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“…The aminopeptidase function is unclear but may be carried out by the RpoH II -dependent putative Zn-dependent peptidases encoded by RSP1096 and RSP1097, which harbor a PqqL peptidase motif. PQQ was shown to be a factor for survival against oxidative stress in vitro (33) and in a bacterial system such as that of E. coli (27).…”

Section: Vol 191 2009mentioning

confidence: 99%

RpoH _II Activates Oxidative-Stress Defense Systems and Is Controlled by RpoE in the Singlet Oxygen-Dependent Response in Rhodobacter sphaeroides

2009

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Photosynthetic organisms need defense systems against photooxidative stress caused by the generation of highly reactive singlet oxygen ( 1 O 2 ). Here we show that the alternative sigma factor RpoH II is required for the expression of important defense factors and that deletion of rpoH II leads to increased sensitivity against exposure to 1 O 2 and methylglyoxal in Rhodobacter sphaeroides. The gene encoding RpoH II is controlled by RpoE, and thereby a sigma factor cascade is constituted. We provide the first in vivo study that identifies genes controlled by an RpoH II -type sigma factor, which is widely distributed in the Alphaproteobacteria. RpoH IIdependent genes encode oxidative-stress defense systems, including proteins for the degradation of methylglyoxal, detoxification of peroxides, 1 O 2 scavenging, and redox and iron homeostasis. Our experiments indicate that glutathione (GSH)-dependent mechanisms are involved in the defense against photooxidative stress in photosynthetic bacteria. Therefore, we conclude that systems pivotal for the organism's defense against photooxidative stress are strongly dependent on GSH and are specifically recognized by RpoH II in R. sphaeroides.

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“…Some unique proteins were also identified in D. radiodurans, such as PprI, 47 which are involved in regulation of cellular antioxidant system and stress response. 18,48 These compounds and proteins might have been responsible for the reduction and stabilization of the synthesized AuNPs in this bacterium.…”

mentioning

confidence: 99%

Biosynthesis of gold nanoparticles by the extreme bacterium <em>Deinococcus radiodurans</em> and an evaluation of their antibacterial properties

et al. 2016

IJN

143

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Pyrroloquinoline–quinone synthesized in Escherichia coli by pyrroloquinoline–quinone synthase of Deinococcus radiodurans plays a role beyond mineral phosphate solubilization

Cited by 50 publications

References 21 publications

Oxidative Stress Resistance inDeinococcus radiodurans

Oxidative Stress Resistance inDeinococcus radiodurans

RpoH _II Activates Oxidative-Stress Defense Systems and Is Controlled by RpoE in the Singlet Oxygen-Dependent Response in Rhodobacter sphaeroides

Biosynthesis of gold nanoparticles by the extreme bacterium <em>Deinococcus radiodurans</em> and an evaluation of their antibacterial properties

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Pyrroloquinoline–quinone synthesized in Escherichia coli by pyrroloquinoline–quinone synthase of Deinococcus radiodurans plays a role beyond mineral phosphate solubilization

Cited by 50 publications

References 21 publications

Oxidative Stress Resistance inDeinococcus radiodurans

Oxidative Stress Resistance inDeinococcus radiodurans

RpoH II Activates Oxidative-Stress Defense Systems and Is Controlled by RpoE in the Singlet Oxygen-Dependent Response in Rhodobacter sphaeroides

Biosynthesis of gold nanoparticles by the extreme bacterium <em>Deinococcus radiodurans</em> and an evaluation of their antibacterial properties

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RpoH _II Activates Oxidative-Stress Defense Systems and Is Controlled by RpoE in the Singlet Oxygen-Dependent Response in Rhodobacter sphaeroides