Pyrroloquinoline-quinone and its versatile roles in biological processes

Misra, Hari S.; Rajpurohit, Yogendra S.; Khairnar, Nivedita P.

doi:10.1007/s12038-012-9195-5

Cited by 132 publications

(88 citation statements)

References 86 publications

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“…Now our findings ascertain that PQQ has the potential to regulate PTU induced adverse effects / hypothyroidism. The possible mechanism of its efficacy to ameliorate PTU induced oxidative stress could be its strong antioxidant properties, as suggested in some previous studies, in which the free radical scavenging activity of PQQ has been clearly shown (Ouchi et al, 2009;Misra et al, 2012). Whatever may be the mechanism of action, from our present findings it is clearly evident that PQQ has the potential to ameliorate PTU induced oxidative stress and it may work against hypothyroidism, although for human therapy point of view, further investigation is required.…”

Section: Discussionsupporting

confidence: 72%

“…This compound has been attributed with multiple physiological functions such as regulation of electron transport system (Kobayashi et al, 2005), enhancing the adaptability of microbes ( Khairnar et al, 2007), improving the growth of plants ( Choi et al, 2008) and stimulating the production of nerve growth factor (Yamaguchi et al, 1993), thus presenting a wide application prospect in pharmaceutical, agriculture and food industries (Andrea et al, 1999;Rucker et al, 2009;Misra et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Kumar¹

2013

IOSR-JPBS

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Kumar¹

2013

IOSR-JPBS

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“…PQQ is characterized as vitaminlike redox cofactor for mammals (Kasahara and Kato, 2003). Its reductive properties make it a good candidate for redox controlled signaling in living cells (Misra et al, 2012) and also more effective than other bioactive quinones and ascorbic acid (Paz et al, 1990). A growth hormone-like activity of PQQ was observed in microorganisms (Shimao et al, 1984) and has been found to act as a growth promoting factor in rodents (Steinberg et al, 1994 and.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Samuel

Zhang

Wang

et al. 2015

Animal

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Pyrroloquinoline quinone (PQQ), a putative essential nutrient and redox modulator in microorganisms, cell and animal models, has been recognized as a growth promoter in rodents. Growth performance, carcass yield and antioxidant status were evaluated on broiler chickens fed different levels of PQQ disodium (PQQ.Na 2 ). A total of 784 day-old male Arbor Acres (AA) broilers were randomly allotted into seven dietary groups: negative control group (NC) fed a basal diet without virginiamycin (VIR) or PQQ.Na 2 ; a positive control group (PC) fed a diet with 15 mg of VIR/kg diet; and PQQ.Na 2 groups fed with 0.05, 0.10, 0.20, 0.40 or 0.80 mg PQQ.Na 2 /kg diet. Each treatment contained eight replicates with 14 birds each. The feeding trial lasted for 6 weeks. The results showed that chicks fed 0.2 mg PQQ.Na 2 /kg diet significantly improved growth performance comparable to those in PC group, and the feed efficiency enhancement effects of dietary PQQ.Na 2 was more apparent in grower phase. Dietary addition of PQQ.Na 2 had the potential to stimulate immune organs development, and low level dietary addition (<0.1 mg/kg) increased plasma lysozyme level. Broilers fed 0.2 mg PQQ.Na 2 /kg diet gained more carcasses at day 42, and had lower lipid peroxide malondialdehyde content and higher total antioxidant power in plasma. The results indicated that dietary PQQ.Na 2 (0.2 mg/kg diet) had the potential to act as a growth promoter comparable to antibiotic in broiler chicks.

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“…One possible mechanism of its efficacy could be its strong antioxidant property, as suggested in some other studies, in which the free radical scavenging activity of PQQ has been clearly shown. 10,51 The other possible mechanism of action of PQQ in ameliorating diabetes could be through peroxisome proliferatoractivated receptor gamma coactivator 1-alpha (PGC-1α); PQQ stimulates PGC-1α expression. 58 Previously it was reported that there is a close relationship among PGC-1α function and diabetes.…”

Section: Effects Of Pyrroloquinoline Quinone and Vitamin C On Diabetementioning

confidence: 99%

“…In recent years, it has been reported that PQQ scavenges ROS, protects from oxidative stress and decreases the levels of free radicals as well as lipid peroxidation (LPO). [8][9][10] One report also suggested that PQQ reduces myocardial infarct size and improves cardiac function. 11 Both in vivo and in vitro studies have shown that PQQ can protect against several types of oxidative damages and irradiation injury.…”

Section: Introductionmentioning

confidence: 99%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Cardiac Oxidative Damages and Hyperlipidemia in Mice: Biochemical and Histopathological Study

Kumar¹,

Kar²

2017

MOJBB

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Enhanced hyperglycemia is associated with oxidative stress and hyperlipidemia that is also responsible for an increased risk factor for diabetes associated cardiovascular problems. As pyrroloquinoline quinone (PQQ) is a known antioxidative agent, the primary aim of this study was to explore the hitherto unknown potential of PQQ in regulating STZ-induced oxidative damages in heart and associated cardiovascular problems. Healthy male mice were divided into seven groups such as normoglycemic; PQQ treated control; STZ-treated (150mg/kg); STZ+PQQ treated (5, 10 and 20mg/ kg, respectively); and STZ+Vit. C treated (50mg/kg). At the end of the experiment( after 15 days of treatment), animals were sacrificed and markers of oxidative stress, various antioxidants, lipid profiles, alterations in insulin, lactate dehydrogenase (LDH), relative risk value (RR-value), atherogenic index (AI) and cardiac tissue histology were evaluated. STZ -treated animals not only developed oxidative stress as indicated by an increase in lipid peroxidation (LPO), lipid hydroperoxide (LOOH), LDH, RR-value and AI but also by a decrease in the levels of insulin, high density lipoprotein (HDL-C), superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione. Following the administration of PQQ, particularly at 20mg/kg in diabetic animals, all these adverse effects were ameliorated with a decrease in LPO, LOOH, LDH and different lipids; with a parallel increase in cellular antioxidants, HDL-C and insulin level, suggesting cardioprotective effects of the test drug. Better effects were observed, as compared to that of Vit. C. Our study reveals that PQQ may have better ameliorating potential than Vit. C in regulation of the cardiovascular problems in diabetic patients.Keywords: diabetes mellitus, pyrroloquinoline quinine, vitamin-C, heart, lactate dehydrogenase, insulin, antioxidative agents MOJ Bioequivalence & Bioavailability Research ArticleOpen Access Effects of pyrroloquinoline quinone and vitamin C on diabetes associated cardiac oxidative damages and hyperlipidemia in mice: biochemical and histopathological study 202Copyright: ©2017 Kumar et al. studies have shown that PQQ can protect against several types of oxidative damages and irradiation injury. Recently, workers found not only the involvement of ROS in the pathogenesis of CVDs, but also suggested the use of antioxidants which play a major role in reducing the oxidative stress by scavenging the excess free radicals. 8,9 In recent years several compounds with antioxidant properties have been found to be beneficial and may protect or restore physiological function in diabetes associated CVDs, mainly plant based compounds have been investigated in details. 12 However, the recently known PQQ has not been tried with respect to its cardio-protective potential in diabetes, if any. An attempt has now been made to evaluate its role in the diabetes-induced CVDs and associated oxidative damage in heart. Citation Materials and methods AnimalsSwiss albino male mice, 7-8 weeks old...

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Pyrroloquinoline-quinone and its versatile roles in biological processes

Cited by 132 publications

References 86 publications

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Cardiac Oxidative Damages and Hyperlipidemia in Mice: Biochemical and Histopathological Study

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