Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents

Abstract

Pyrrolopyrimidine derivatives comprise a class of biologically active heterocyclic compounds that are well known to play a critical role in pharmaceutical drug design and health care. The pyrrolopyrimidines serve as promising scaffolds that were found in a number of biologically active compounds including antibiotics, anti-inflammatory, anti-viral and anticancer. Researchers were inspired to develop novel pyrrolopyrimidine derivatives for the treatment of Cancer. Currently several pyrrolopyrimidines are available commercially as anticancer drugs. The present review article offers a detailed account on the development of pyrrolopyrimidine derivatives with anticancer potential with emphasis on their activity as targeted kinase inhibitors.

Acrylamide moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

“…Protein kinases represent a huge family of cellular enzymes which are pivotal in signal transduction pathways that control numerous cellular functions, including proliferation, differentiation, migration, apoptosis, and angiogenesis 80 . protein kinase enzymes represent a potential target for TCI's as a result of the high density of nucleophilic residues at active sites of protein kinases.…”

“…BTK controls various signal transduction pathways of B cells. Dysregulation of BTK was linked to number of B cell malignancies 80 . Ibrutinib a purine analogue bearing a terminal acrylamide moiety was the 1st BTK inhibitor approved by FDA in 2013 for treatment of mantle cell lymphoma.…”