Pyrrolo[2,1-a]isoquinoline scaffolds for developing anti-cancer agents

Abstract

Fused pyrrolo[2,1-a]isoquinolines have emerged as compelling molecules with remarkably potent cytotoxic activity and topoisomerase inhibitors.

Cascade Synthesis of Pyrrolo[1,2-a]quinolines and Pyrrolo[2,1-a]isoquinolines via Formal [3 + 2]-Cycloaddition of Push–Pull Nitro Heterocycles with Carbonyl-Stabilized Quinolinium/Isoquinolinium Ylides

“…Thus, the main reason for the interest in pyrrolo­[1,2- a ]­quinoline and pyrrolo­[2,1- a ]­isoquinoline is driven by the high biological activity of both scaffolds with a remarkable tendency to exhibit anticancer activity . At the same time, another trend has emerged in the last year toward the formation of synthetic toolbox for their functionalization; in particular, chlorination, bromination, nitration, sulfenilation, oxidation, formylation, benzylation, allenylation, methylthio- and aminomethylation reactions have been unveiled .…”

Photo-induced tungsten-catalyzed cascade synthesis of pyrrolo[2,1-a]isoquinoline-1,3-dicarboxylate and its reaction mechanism

“…2,3 In light of its importance in this regard, numerous studies have been devoted to the synthesis of pyrrolo[2,1- a ]isoquinoline. 4…”